58 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cul4a/Pcid2tm2Ktc/Cul4a/Pcid2tm2Ktc Tg(Mx1-cre)1Cgn/0 involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	abnormal definitive hematopoiesis	J:138468
	abnormal enterocyte morphology	J:138468
	abnormal leukocyte morphology	J:138468
	abnormal small intestine crypts of Lieberkuhn morphology	J:138468
	abnormal spleen capsule morphology	J:138468
	abnormal spleen morphology	J:138468
	decreased bone marrow cell number	J:138468
	decreased hematocrit	J:138468
	decreased hematopoietic stem cell number	J:138468
	decreased lymphocyte cell number	J:138468
	decreased monocyte cell number	J:138468
	decreased neutrophil cell number	J:138468
	decreased spleen red pulp amount	J:138468
	decreased spleen weight	J:138468
	decreased spleen white pulp amount	J:138468
	impaired hematopoiesis	J:138468
	increased enterocyte apoptosis	J:138468
	premature death	J:138468
	small intestinal villus atrophy	J:138468
	small thymus	J:138468
	spleen hypoplasia	J:138468
	thrombocytopenia	J:138468
Cul4atm1.1Pra/Cul4atm1.1Pra involves: C57BL/6NTac	abnormal cell cycle checkpoint function	J:172043
	abnormal centrosome morphology	J:172043
	abnormal DNA replication	J:172043
	chromosomal instability	J:172043
	decreased fibroblast proliferation	J:172043
	increased cellular sensitivity to ultraviolet irradiation	J:172043
Cul4atm1.1Pra/Cul4atm1.1Pra Not Specified	normal reproductive system phenotype	J:171470
Cul4atm1.1Pra/Cul4atm1.1Pra Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: C57BL/6 * C57BL/6NTac * DBA	decreased body weight	J:172043
	decreased hepatocyte proliferation	J:172043
	increased susceptibility to injury	J:172043
Cul4atm1.1Pz/Cul4atm1.1Pz Tg(KRT14-cre/ERT)20Efu/? involves: C57BL/6 * CD-1	decreased incidence of tumors by UV induction	J:150427
Cul4atm1.2Pra/Cul4atm1.2Pra Not Specified	abnormal double-strand DNA break repair	J:171470
	abnormal male meiosis	J:171470
	abnormal sperm flagellum morphology	J:171470
	abnormal sperm head morphology	J:171470
	abnormal spermatid morphology	J:171470
	abnormal spermatocyte morphology	J:171470
	abnormal spermatogenesis	J:171470
	asthenozoospermia	J:171470
	azoospermia	J:171470
	decreased litter size	J:171470
	decreased testis weight	J:171470
	increased male germ cell apoptosis	J:171470
	male infertility	J:171470
	multinucleated giant male germ cells	J:171470
	oligozoospermia	J:171470
	reduced female fertility	J:171470
	small epididymis	J:171470
	small testis	J:171470
Cul4atm1.2Pz/Cul4atm1.2Pz B6.Cg-Cul4atm1.2Pz	abnormal cell cycle checkpoint function	J:150427
	abnormal DNA repair	J:150427
Cul4atm1b(EUCOMM)Hmgu/Cul4atm1b(EUCOMM)Hmgu C57BL/6N-Cul4atm1b(EUCOMM)Hmgu/Ccpcz	abnormal retina morphology	J:211773
	abnormal testis morphology	J:211773
	decreased mean platelet volume	J:211773
	decreased spleen weight	J:211773
	increased circulating potassium level	J:211773
	increased fasting circulating glucose level	J:211773
	male infertility	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	small testis	J:211773