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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smad2
SMAD family member 2
MGI:108051
97 phenotypes from 18 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal reproductive system phenotype J:142827
Smad2m1Mag/Smad2+
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6) 		no abnormal phenotype detected J:80520
Smad2m1Mag/Smad2m1Mag
either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6) 		abnormal dorsal aorta morphology J:80520
abnormal embryonic tissue morphology J:80520
abnormal heart development J:80520
abnormal heart tube morphology J:80520
absent foregut J:80520
absent notochord J:80520
absent optic placodes J:80520
embryonic lethality, complete penetrance J:80520
failure of chorioallantoic fusion J:80520
rostral body truncation J:80520
Smad2m1Mag/Smad2tm1Rob
either: (involves: 129S/Sv * 129S/SvEv * Black Swiss) or (involves: 129S/Sv * 129S/SvEv * C57BL/6) 		abnormal embryonic tissue morphology J:80520
embryonic lethality during organogenesis, complete penetrance J:80520
Smad2tm1.1Epb/Smad2tm1.1Epb
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129/Sv * C57BL/6 * DBA * SJL 		abnormal cell differentiation J:119642
abnormal cell migration J:119642
abnormal hepatocyte morphology J:119642
abnormal hepatocyte physiology J:119642
increased hepatocyte proliferation J:119642
normal liver/biliary system phenotype J:119642
Smad2tm1.1Mwst/Smad2tm1.1Mwst
involves: 129S6/SvEvTac * Black Swiss 		no abnormal phenotype detected J:94232
Smad2tm1.1Mwst/Smad2tm1.2Mwst
involves: 129S6/SvEvTac * Black Swiss 		no abnormal phenotype detected J:94232
Smad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal cerebellar foliation J:173787
abnormal cerebellar granule cell migration J:173787
abnormal cerebellar granule cell morphology J:173787
abnormal cerebellum morphology J:173787
abnormal cerebellum vermis lobule IX morphology J:173787
abnormal cerebellum vermis lobule X morphology J:173787
abnormal gait J:173787
abnormal locomotor coordination J:173787
abnormal posture J:173787
abnormal Purkinje cell dendrite morphology J:173787
ataxia J:173787
decreased body size J:173787
decreased CNS synapse formation J:173787
impaired balance J:173787
increased neuron apoptosis J:173787
limb grasping J:173787
normal nervous system phenotype J:173787
premature death J:173787
short stride length J:173787
slow postnatal weight gain J:173787
tremors J:173787
Smad2tm1.2Mwst/Smad2+
involves: 129S6/SvEvTac * Black Swiss 		abnormal developmental patterning J:94232
Smad2tm1.2Mwst/Smad2tm1.2Mwst
involves: 129S6/SvEvTac * Black Swiss 		decreased embryo size J:94232
Smad2tm1Cxd/Smad2+
involves: 129S6/SvEvTac * C57BL/6 		abnormal eye morphology J:76396
abnormal mandible morphology J:76396
abnormal Meckel's cartilage morphology J:76396
Smad2tm1Cxd/Smad2tm1Cxd
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal developmental patterning J:49084
abnormal ectoplacental cone morphology J:49084
abnormal egg cylinder morphology J:49084
abnormal extraembryonic endoderm formation J:49084
abnormal extraembryonic tissue morphology J:49084
absent allantois J:49084
absent amnion J:49084
absent chorion J:49084
absent extraembryonic ectoderm J:49084
absent head fold J:49084
absent mesoderm J:49084
decreased egg cylinder size J:49084
decreased embryo size J:49084
embryonic growth arrest J:49084
embryonic lethality between implantation and somite formation, complete penetrance J:49084
failure of primitive streak formation J:49084
failure to gastrulate J:49084
Smad2tm1Cxd/Smad2tm1Mwst
involves: 129S6/SvEvTac * Black Swiss 		embryonic lethality, complete penetrance J:94232
Smad2tm1Enl/Smad2+
involves: 129S4/SvJae 		abnormal craniofacial morphology J:48467
abnormal embryonic tissue morphology J:48467
abnormal eye development J:48467
abnormal mandible morphology J:48467
abnormal primitive streak elongation J:48467
absent allantois J:48467
absent amnion J:48467
absent mandible J:48467
embryonic growth retardation J:48467
mandible hypoplasia J:48467
Smad2tm1Enl/Smad2tm1Enl
involves: 129S4/SvJae 		abnormal developmental patterning J:48467
abnormal embryonic epiblast morphology J:48467
abnormal embryonic-extraembryonic boundary morphology J:48467
abnormal extraembryonic endoderm formation J:48467
abnormal extraembryonic tissue morphology J:48467
abnormal proamniotic cavity morphology J:48467
abnormal proximal-distal axis patterning J:48467
abnormal rostral-caudal axis patterning J:48467
abnormal visceral endoderm morphology J:48467
absent mesoderm J:48467
decreased embryo size J:48467
embryonic growth retardation J:48467
embryonic lethality, complete penetrance J:48467
failure of primitive streak formation J:48467
Smad2tm1Kato/Smad2tm1Kato
involves: 129S4/SvJae * C57BL/6J 		abnormal developmental patterning J:79668
abnormal extraembryonic tissue morphology J:79668
Smad2tm1Mwst/Smad2tm1.2Mwst
involves: 129S6/SvEvTac * Black Swiss 		abnormal developmental patterning J:94232
embryonic lethality during organogenesis, complete penetrance J:94232
Smad2tm1Mwst/Smad2tm1Mwst
involves: 129S6/SvEvTac * Black Swiss 		no abnormal phenotype detected J:94232
Smad2tm1Rak/Smad2tm1Rak
involves: 129/Sv * C57BL/6J * SJL 		abnormal embryonic tissue morphology J:73507
embryonic lethality between implantation and somite formation, complete penetrance J:73507
Smad2tm1Rob/Smad2tm1Rob
involves: 129S/SvEv 		abnormal chorion morphology J:46532
abnormal embryonic epiblast morphology J:46532
abnormal embryonic tissue morphology J:46532
abnormal rostral-caudal axis patterning J:46532
absent ectoderm J:46532
absent endoderm J:46532
absent mesoderm J:46532
absent primitive node J:46532
embryonic lethality during organogenesis, complete penetrance J:46532
failure of primitive streak formation J:46532
Smad2tm1Rob/Smad2tm2.1Rob
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1 		abnormal embryonic tissue morphology J:84300
abnormal rostral-caudal axis patterning J:84300
embryonic lethality during organogenesis J:84300
Smad2tm1Rob/Smad2tm2Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA * CD-1 		abnormal anterior definitive endoderm morphology J:84300
abnormal heart looping J:84300
abnormal rostral-caudal axis patterning J:84300
absent forebrain J:84300
absent midbrain J:84300
enlarged pericardium J:84300
pericardial edema J:84300
truncated foregut J:84300
Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0
involves: 129S6/SvEvTac 		abnormal wound healing J:178733
enhanced wound healing J:178733
increased keratinocyte migration J:178733
Smad2tm2.1Rob/Smad2tm2.1Rob
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1 		abnormal embryonic tissue morphology J:84300
abnormal rostral-caudal axis patterning J:84300
embryonic lethality during organogenesis J:84300
Smad2tm2Enl/Smad2+
involves: 129S4/SvJae 		abnormal craniofacial morphology J:48467
abnormal embryonic tissue morphology J:48467
abnormal eye development J:48467
abnormal mandible morphology J:48467
embryonic growth retardation J:48467
Smad2tm2Enl/Smad2tm2Enl
involves: 129S4/SvJae 		abnormal rostral-caudal axis patterning J:48467
embryonic growth retardation J:48467
embryonic lethality, complete penetrance J:48467
Smad2tm2Kato/Smad2tm2Kato
involves: 129S4/SvJae * C57BL/6J 		abnormal developmental patterning J:79668
abnormal extraembryonic tissue morphology J:79668
Smad2tm2Rob/Smad2tm2Rob
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:84300
Smad2tm3Rob/Smad2tm3Rob
involves: 129S/SvEv * C57BL/6 * ICR 		no abnormal phenotype detected J:95374
Smad2Tn(pb-Act-RFP)1.090901064-HRAZhu/Smad2+
involves: FVB/NJ 		normal behavior/neurological phenotype J:378174
decreased body fat mass J:378174
decreased body weight J:378174
decreased total body fat amount J:378174
increased carbon dioxide production J:378174
increased energy expenditure J:378174
increased oxygen consumption J:378174
Smad2Tn(pb-Act-RFP)1.090901064-HRAZhu/Smad2Tn(pb-Act-RFP)1.090901064-HRAZhu
involves: FVB/NJ 		abnormal cardiovascular development J:378174
abnormal liver development J:378174
abnormal vascular development J:378174
decreased body size J:378174
embryonic growth retardation J:378174
embryonic lethality during organogenesis, complete penetrance J:378174
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03/24/2026
MGI 6.24 		The Jackson Laboratory