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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mdm4
transformed mouse 3T3 cell double minute 4
MGI:107934
59 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
involves: 129S/Sv * C57BL/6 		enlarged liver J:150341
enlarged lymph nodes J:150341
enlarged spleen J:150341
increased B cell derived lymphoma incidence J:150341
increased lymphoma incidence J:150341
increased splenocyte proliferation J:150341
premature death J:150341
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cell physiology J:123661
abnormal cerebellar granule layer morphology J:123661
abnormal cerebellum external granule cell layer morphology J:123661
abnormal definitive hematopoiesis J:123661
abnormal Purkinje cell morphology J:123661
anemia J:123661
cerebellum hypoplasia J:123661
cleft palate J:123661
decreased body weight J:123661
decreased bone marrow cell number J:123661
decreased embryo size J:123661
decreased erythrocyte cell number J:123661
decreased fetal size J:123661
decreased hemoglobin content J:123661
decreased leukocyte cell number J:123661
decreased renal glomerulus number J:123661
exencephaly J:123661
increased embryonic tissue cell apoptosis J:123661
kinked tail J:123661
pallor J:123661
pancytopenia J:123661
postnatal lethality, complete penetrance J:123661
prenatal lethality, incomplete penetrance J:123661
spleen atrophy J:123661
spleen hypoplasia J:123661
thrombocytopenia J:123661
thymus atrophy J:123661
thymus hypoplasia J:123661
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S7/SvEvBrd 		abnormal Purkinje cell morphology J:174216
anemia J:174216
decreased bone marrow cell number J:174216
decreased cerebellar granule cell number J:174216
increased foot pad pigmentation J:174216
normal mortality/aging J:71532
small cerebellum J:174216
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal mortality/aging J:123661
Mdm2tm1Glo/Mdm2+
Mdm4tm2.1Glo/Mdm4+
involves: 129S7/SvEvBrd 		increased foot pad pigmentation J:174216
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S5/SvEvBrd * C57BL/6 		abnormal cell cycle J:108183
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1.1Xlu/Trp53tm1.1Xlu
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal embryo development J:166152
embryonic growth retardation J:166152
embryonic lethality during organogenesis, incomplete penetrance J:166152
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1.1Xlu/Trp53tm1.1Xlu
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N 		normal cellular phenotype J:166152
embryonic lethality during organogenesis, incomplete penetrance J:166152
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S5/SvEvBrd 		decreased embryo size J:77907
preweaning lethality, complete penetrance J:77907
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S5/SvEvBrd 		abnormal cell cycle checkpoint function J:77907
decreased cellular sensitivity to ultraviolet irradiation J:77907
normal embryo phenotype J:77907
increased fibroblast proliferation J:77907
normal mortality/aging J:77907
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S5/SvEvBrd * C57BL/6 		abnormal cell cycle J:108183
decreased cell proliferation J:108183
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129S4/SvJae * 129S5/SvEvBrd 		abnormal cell cycle J:108183
decreased fibroblast proliferation J:108183
normal mortality/aging J:108183
Mdm4tm1Glo/Mdm4+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		normal mortality/aging J:123661
Mdm4tm1Glo/Mdm4+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL 		increased B cell derived lymphoma incidence J:123661
Mdm4tm1Glo/Mdm4+
Rpl27aSfa/Rpl27a+
involves: C57BL/6J 		prenatal lethality, complete penetrance J:174216
Mdm4tm1Glo/Mdm4+
Trp53tm1.1Tldo/Trp53+
involves: 129S2/SvPas * BALB/c * C57BL/6 		decreased bone marrow cell number J:199308
decreased telomere length J:199308
premature death J:199308
Mdm4tm1Glo/Mdm4tm1Glo
Trp53tm1Adv/Trp53tm1Adv
involves: 129S4/SvJae 		abnormal embryo development J:93838
embryonic growth retardation J:93838
preweaning lethality, complete penetrance J:93838
Mdm4tm1Glo/Mdm4tm1Glo
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas 		abnormal embryo development J:93838
preweaning lethality, complete penetrance J:93838
Mdm4tm1Glo/Mdm4tm1Glo
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas 		normal mortality/aging J:71532, J:93838
Mdm4tm1Zmy/Mdm4tm1Zmy
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6 		no abnormal phenotype detected J:174359
Mdm4tm2.1Glo/Mdm4tm2.1Glo
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J 		no abnormal phenotype detected J:104114
Mdm4tm2Glo/Mdm4tm2.1Glo
Tg(Myh6-cre)2182Mds/0
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N 		extended life span J:137114
Mdm4tm2Glo/Mdm4tm2.1Glo
Tg(Myh6-cre)2182Mds/0
Trp53tm1Tyj/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N 		normal cardiovascular system phenotype J:137114
decreased tumor-free survival time J:137114
extended life span J:137114
increased tumor incidence J:137114
Mdm4tm3.1Glo/Mdm4+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal mortality/aging J:174368
Mdm4tm3.1Glo/Mdm4tm3.1Glo
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:174368
Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm3.1Glo/Trp53tm3.1Glo
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N 		normal mortality/aging J:174368
Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm4Glo/Trp53tm4Glo
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N 		normal mortality/aging J:174368
Mdm4tm3Glo/Mdm4tm3.1Glo
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		no abnormal phenotype detected J:174368
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory