153 phenotypes from 15 alleles in 29 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptch1dl/Ptch1dl involves: 129S1/SvImJ * C57BL/6J	abnormal basicranium morphology	J:204468
	abnormal basisphenoid bone morphology	J:204468
	abnormal cranium morphology	J:204468
	abnormal frontal bone morphology	J:204468
	abnormal head morphology	J:204468
	abnormal interparietal bone morphology	J:204468
	abnormal intramembranous bone ossification	J:204468
	abnormal lambdoid suture morphology	J:204468
	abnormal parietal bone morphology	J:204468
	abnormal sternum manubrium morphology	J:204468
	abnormal sternum morphology	J:204468
	abnormal xiphoid process morphology	J:204468
	absent palatal shelf	J:204468
	absent presphenoid bone	J:204468
	alisphenoid bone hypoplasia	J:204468
	asymmetric sternocostal joints	J:204468
	cleft secondary palate	J:204468
	domed cranium	J:204468
	increased body size	J:204468
	palatal shelf hypoplasia	J:204468
	postnatal lethality, complete penetrance	J:204468
	preaxial polydactyly	J:204468
	scapular bone foramen	J:204468
	short mandibular coronoid process	J:204468
	small basisphenoid bone	J:204468
Ptch1dl/Ptch1tm1Mps involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J	abnormal craniofacial morphology	J:204468
	abnormal interparietal bone morphology	J:204468
	abnormal lambdoid suture morphology	J:204468
	abnormal neurocranium morphology	J:204468
	abnormal parietal bone morphology	J:204468
	abnormal sternum morphology	J:204468
	absent presphenoid bone	J:204468
	alisphenoid bone hypoplasia	J:204468
	exencephaly	J:204468
	kinked tail	J:204468
	lethality throughout fetal growth and development, incomplete penetrance	J:204468
	mandibular coronoid process hypoplasia	J:204468
	palatal shelf hypoplasia	J:204468
	preaxial polydactyly	J:204468
	scapular bone foramen	J:204468
	small basisphenoid bone	J:204468
	syndactyly	J:204468
Ptch1dl/Ptch1tm1Zim involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J	abnormal head morphology	J:204468
	domed cranium	J:204468
	increased fetal size	J:204468
	kinked tail	J:204468
	omphalocele	J:204468
Ptch1mes/Ptch1mes B6C3Fe a/a-Ptch1mes	abnormal foot pad morphology	J:32739
	abnormal skeleton morphology	J:23861
	abnormal spermatogenesis	J:32739
	abnormal tendon morphology	J:23861
	abnormal thoracic cavity morphology	J:32739
	belly spot	J:23861
	cryptorchism	J:23861
	decreased fear-related response	J:32739
	dermal hyperplasia	J:23861, J:32739
	female infertility	J:23861
	kinked tail	J:23861
	kyphosis	J:32739
	male infertility	J:23861
	ocular hypertelorism	J:23861
	polydactyly	J:23861
	short tail	J:23861
	shortened head	J:23861
	small male preputial gland	J:32739
	small seminal vesicle	J:32739
	thick tail	J:32739
Ptch1mes/Ptch1mes involves: CBA/J	abnormal enamel morphology	J:156471
	abnormal upper incisor morphology	J:156471
Ptch1tm1.1Bjw/Ptch1tm1.1Bjw involves: 129T2/SvEms * C57BL/6J	abnormal craniofacial morphology	J:85040
	abnormal telencephalon development	J:85040
	absent forebrain	J:85040
	embryonic growth arrest	J:85040
	open neural tube	J:85040
	prenatal lethality	J:85040
Ptch1tm1.1Hahn/Ptch1+ involves: 129 * BALB/c * C57BL/6 * FVB/N	increased medulloblastoma incidence	J:149148
	increased rhabdomyosarcoma incidence	J:149148
	increased tumor incidence	J:149148
	premature death	J:149148
Ptch1tm1.1Hahn/Ptch1tm1.1Hahn involves: 129 * BALB/c * C57BL/6 * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:149148
	open neural tube	J:149148
Ptch1tm1Bjw/Ptch1tm1Bjw involves: 129T2/SvEms	increased neuronal precursor cell number	J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw involves: 129T2/SvEms * C57BL/6J	no abnormal phenotype detected	J:85040
Ptch1tm1Bjw/Ptch1tm1Bjw Tcf21tm1(cre)Seq/Tcf21+ involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ	abnormal kidney collecting duct morphology	J:189643
	abnormal kidney morphology	J:189643
	abnormal kidney pelvis morphology	J:189643
	increased tumor incidence	J:189643
	kidney cyst	J:189643
	prenatal lethality	J:189643
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre)1Bfri/0 involves: 129T2/SvEms * C57BL/6 * CBA	abnormal cerebellum external granule cell layer morphology	J:139573
	abnormal cerebellum morphology	J:139573
	abnormal neuronal precursor proliferation	J:139573
	enlarged cerebellum	J:139573
	increased medulloblastoma incidence	J:139573
	increased neuronal precursor cell number	J:189258
	normal nervous system phenotype	J:189258
	premature death	J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre/Esr1*)14Fsh/0 involves: 129T2/SvEms * FVB/N	abnormal cerebellum external granule cell layer morphology	J:139573
	abnormal neuronal precursor proliferation	J:139573
	enlarged cerebellum	J:139573
	increased medulloblastoma incidence	J:139573
	premature death	J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(GFAP-cre)25Mes/0 involves: 129T2/SvEms * FVB/N	abnormal cerebellum external granule cell layer morphology	J:139573
	abnormal rhombic lip morphology	J:139573
	increased medulloblastoma incidence	J:139573
	increased neuronal precursor cell number	J:139573
	premature death	J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(KRT14-cre)8Brn/0 involves: 129T2/SvEms * FVB/N	decreased circulating insulin-like growth factor I level	J:231264
	increased basal cell carcinoma incidence	J:231264
	infertility	J:231264
	postnatal growth retardation	J:231264
	skin lesions	J:231264
	thymus hypoplasia	J:231264
Ptch1tm1Cklr/Ptch1+ Pax7tm1(cre)Mrc/Pax7+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	ataxia	J:159972
	increased medulloblastoma incidence	J:159972
Ptch1tm1Cklr/Ptch1tm1Cklr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	normal neoplasm	J:159972
Ptch1tm1Hahn/Ptch1+ Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	premature death	J:149148
Ptch1tm1Hahn/Ptch1+ Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	epidermal cyst	J:149148
	increased fibroma incidence	J:149148
	increased tumor incidence	J:149148
	premature death	J:149148
Ptch1tm1Hahn/Ptch1tm1Hahn involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:127207
Ptch1tm1Hahn/Ptch1tm1Hahn Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	decreased tumor growth/size	J:158915
	increased basal cell carcinoma incidence	J:158915
Ptch1tm1Hahn/Ptch1tm1Hahn Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	increased basal cell carcinoma incidence	J:149148
	increased tumor incidence	J:149148
	premature death	J:149148
Ptch1tm1Hahn/Ptch1tm1Hahn Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal double-negative T cell morphology	J:127207
	abnormal hematopoietic system morphology/development	J:127207
	abnormal thymus lobule morphology	J:127207
	decreased B cell number	J:127207
	decreased double-positive T cell number	J:127207
	decreased immature B cell number	J:127207
	decreased lymphocyte cell number	J:127207
	decreased pre-B cell number	J:127207
	decreased transitional stage B cell number	J:127207
	increased B cell number	J:127207
	increased basal cell carcinoma incidence	J:149148
	increased double-negative T cell number	J:127207
	increased mature B cell number	J:127207
	increased neutrophil cell number	J:127207
	increased single-positive T cell number	J:127207
	increased tumor incidence	J:149148
	premature death	J:149148
	thymus hypoplasia	J:127207
Ptch1tm1Kmmt/Ptch1+ involves: 129S7/SvEvBrd * C57BL/6J	mandibular cyst	J:102978
Ptch1tm1Mps/Ptch1+ involves: 129S1/Sv * 129X1/SvJ	focal hair loss	J:82653
	increased medulloblastoma incidence	J:102702, J:114992, J:144811
	increased rhabdomyosarcoma incidence	J:114992
	increased skin tumor incidence	J:82653
Ptch1tm1Mps/Ptch1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cerebellar molecular layer	J:205254
	decreased tumor-free survival time	J:205254
	increased gastrointestinal tumor incidence	J:205254
	increased hemangiosarcoma incidence	J:205254
	increased lymphoma incidence	J:205254
	increased medulloblastoma incidence	J:205254
	increased rhabdomyosarcoma incidence	J:205254
	increased tumor incidence	J:205254
	premature death	J:112118
Ptch1tm1Mps/Ptch1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	increased body size	J:42441
	increased medulloblastoma incidence	J:42441
	increased tumor incidence	J:42441
	polydactyly	J:42441
	syndactyly	J:42441
Ptch1tm1Mps/Ptch1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J	increased basal cell carcinoma incidence	J:58328
	increased incidence of tumors by ionizing radiation induction	J:58328
	increased incidence of tumors by UV-induction	J:58328
Ptch1tm1Mps/Ptch1+ Tg(Atoh1-GFP)1Jejo/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	increased medulloblastoma incidence	J:144811
Ptch1tm1Mps/Ptch1tm1Mps involves: 129S1/Sv * 129X1/SvJ	craniorachischisis	J:297055
	embryonic lethality prior to organogenesis	J:297055
Ptch1tm1Mps/Ptch1tm1Mps involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal heart development	J:42441
	embryonic lethality, complete penetrance	J:42441
	open neural tube	J:42441
Ptch1tm1Mps/Ptch1tm1Mps involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	embryonic lethality during organogenesis, complete penetrance	J:79392
Ptch1tm1Mps/Ptch1tm1Mps Tg(Mt1-Ptch1)MT22Mps/0 involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal diencephalon morphology	J:94269
	abnormal neural tube morphology	J:94269
	abnormal neuronal precursor cell number	J:94269
Ptch1tm1Yy/Ptch1+ Tg(BGLAP-cre)1Clem/0 involves: 129 * C57BL/6 * FVB/NJ	normal mortality/aging	J:214349
	normal neoplasm	J:214349
Ptch1tm1Yy/Ptch1tm1.1Yy Tg(Col2a1-cre)1Bhr/0 involves: C57BL/6 * SJL	abnormal bone mineralization	J:112462
	abnormal bone ossification	J:112462
	abnormal cranium morphology	J:112462
	abnormal long bone hypertrophic chondrocyte zone	J:112462
	abnormal osteoblast differentiation	J:112462
	decreased length of long bones	J:112462
	fused synovial joints	J:112462
	increased chondrocyte proliferation	J:112462
Ptch1tm1Yy/Ptch1tm1Yy Not Specified	prenatal lethality, incomplete penetrance	J:112462
Ptch1tm1Yy/Ptch1tm1Yy Tg(BGLAP-cre)1Clem/0 involves: 129 * C57BL/6 * FVB/NJ	abnormal bone ossification	J:214349
	premature death	J:214349
Ptch1tm1Zim/Ptch1+ either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	abnormal rib morphology	J:47421
	decreased rib number	J:47421
	dermal cyst	J:47421
	exencephaly	J:47421
	incomplete rostral neuropore closure	J:47421
	increased body size	J:47421
	increased fetal size	J:47421
	increased incidence of tumors by ionizing radiation induction	J:47421
	increased medulloblastoma incidence	J:47421
	increased rhabdomyosarcoma incidence	J:47421
	lethality throughout fetal growth and development, incomplete penetrance	J:47421
	mandibular cyst	J:47421
	polydactyly	J:47421
	preaxial polydactyly	J:47421
Ptch1tm1Zim/Ptch1+ involves: 129 * CD-1	increased incidence of tumors by ionizing radiation induction	J:79666, J:165388
	increased medulloblastoma incidence	J:79666, J:165388
	increased mortality induced by ionizing radiation	J:79666
Ptch1tm1Zim/Ptch1tm1Zim involves: 129	abnormal neural tube closure	J:47421
	embryonic lethality during organogenesis, incomplete penetrance	J:47421
Ptch1tm2Mps/Ptch1tm2Mps involves: 129S1/Sv * 129X1/SvJ	infertility	J:82653
Ptch1wig/Ptch1wig involves: 129S1/Sv * C57BL/6 * FVB/NJ	abnormal cranial ganglia morphology	J:171522
	abnormal geniculate ganglion morphology	J:171522
	abnormal glossopharyngeal ganglion morphology	J:171522
	abnormal mandibular prominence morphology	J:171522
	abnormal maxillary prominence morphology	J:171522
	abnormal nasal placode morphology	J:171522
	abnormal nervous system morphology	J:171522
	abnormal neural plate morphology	J:171522
	abnormal neuron differentiation	J:171522
	abnormal trigeminal ganglion morphology	J:171522
	abnormal vascular development	J:171522
	abnormal vestibulocochlear ganglion morphology	J:171522
	absent fourth pharyngeal arch	J:171522
	absent optic vesicle	J:171522
	absent third pharyngeal arch	J:171522
	craniorachischisis	J:171522
	embryonic lethality during organogenesis, complete penetrance	J:171522
	exencephaly	J:171522
	increased embryo size	J:171522
	open neural tube	J:171522
	small otic vesicle	J:171522
	small second pharyngeal arch	J:171522