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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il4ra
interleukin 4 receptor, alpha
MGI:105367
45 phenotypes from 8 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il4raM1Btlr/Il4raM1Btlr
C57BL/6J-Il4raM1Btlr 		decreased IgE level J:267558
Il4raM2Btlr/Il4raM2Btlr
C57BL/6J-Il4raM2Btlr 		decreased IgE level J:272804
Il4ratm1Fbb/Il4ratm1Fbb
involves: BALB/c 		abnormal susceptibility to infection J:55526
Il4ratm1Fbb/Il4ratm1Fbb
involves: BALB/cJ 		abnormal circulating cytokine level J:133518
abnormal circulating interferon-gamma level J:133518
abnormal crypts of Lieberkuhn morphology J:133518
abnormal cytokine secretion J:114751
abnormal immune system physiology J:114751
abnormal intestinal epithelium morphology J:133518
abnormal macrophage physiology J:114751
decreased T-helper 2 cell number J:172134
granulomatous inflammation J:114751
impaired macrophage chemotaxis J:114751
increased circulating interleukin-4 level J:133518
increased susceptibility to infection J:114751
increased susceptibility to parasitic infection J:114751
increased transforming growth factor beta level J:133518
liver inflammation J:114751
premature death J:114751
weight loss J:114751
Il4ratm1Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * BALB/c 		abnormal immune system physiology J:114751
abnormal intestinal goblet cell morphology J:114751
abnormal macrophage physiology J:114751
decreased susceptibility to parasitic infection J:114751
granulomatous inflammation J:114751
increased susceptibility to parasitic infection J:114751
liver fibrosis J:114751
liver inflammation J:114751
premature death J:114751
weight loss J:114751
Il4ratm1Sz/Il4ratm1Sz
BALB/c-Il4ratm1Sz 		increased IgG2a level J:110429
increased susceptibility to parasitic infection J:110429
Il4ratm1Sz/Il4ratm1Sz
BALB/c-Il4ratm1Sz/J 		abnormal microglial cell morphology J:125605
abnormal susceptibility to infection J:131994
abnormal T-helper 2 physiology J:43656
decreased IgE level J:43656
decreased IgG1 level J:43656
decreased interleukin-4 secretion J:43656
decreased interleukin-5 secretion J:43656
decreased interleukin-10 secretion J:43656
increased IgG2a level J:43656
Il4ratm1Tch/Il4ratm1Tch
involves: 129X1/SvJ * BALB/c 		abnormal immune serum protein physiology J:86215
abnormal T-helper 2 cell morphology J:86215
decreased T cell proliferation J:86215
increased airway responsiveness J:86215
increased IgE level J:86215
increased IgG level J:86215
respiratory system inflammation J:86215
Il4ratm2Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/?
involves: 129P2/OlaHsd * BALB/c 		decreased core body temperature J:178294
decreased fatty acids level J:178294
Il4ratm2Tch/Il4ratm2Tch
C.129X1-Il4ratm2Tch 		abnormal bronchus morphology J:152376
abnormal T-helper 2 physiology J:152376
increased airway responsiveness J:152376
increased circulating interleukin-4 level J:152376
increased eosinophil cell number J:152376
increased IgE level J:152376
increased monocyte cell number J:152376
increased respiratory mucosa goblet cell number J:152376
increased susceptibility to type I hypersensitivity reaction J:152376
respiratory system inflammation J:152376
Il4ratm3.1Tch/Il4ratm3.1Tch
C.129X1-Il4ratm3.1Tch 		abnormal macrophage activation involved in immune response J:160806
increased IgE level J:160806
increased interleukin-4 secretion J:160806
increased susceptibility to type I hypersensitivity reaction J:160806
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory