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Targeted Allele Detail
Symbol: Il4ratm1Tch
Name: interleukin 4 receptor, alpha; targeted mutation 1, Talal A Chatila
MGI ID: MGI:2680722
Synonyms: Y500F
Gene: Il4ra  Location: Chr7:125151443-125178646 bp, + strand  Genetic Position: Chr7, 68.94 cM
Alliance: Il4ratm1Tch page
Germline Transmission:  Earliest citation of germline transmission: J:86215
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA single A to T substitution was created at the position equivalent to 1735 of the cDNA. This caused a codon change for amino acid residue 500 from tyrosine to phenylalanine (Y500F) disrupting the PTB domain. In addition, a floxed PGK-neomycin resistance cassette was inserted into intron 11. This cassette was removed from successfully targeted clones by transient transfection with a Cre recombinase. The mutant is transcribed at rates equivalent to those of wild-type as indicated by RT-PCR. (J:86215)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:  41 strains or lines available
Original:  J:86215 Blaeser F, et al., Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20;198(8):1189-200
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory