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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat5a
signal transducer and activator of transcription 5A
MGI:103036
80 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Gt(ROSA)26Sortm3(CAG-EYFP)Hze/\Gt(ROSA)26Sor+
\Stat5atm2Mam \Stat5btm1Mam/\Del(11Stat5a-Stat5b)1Mam
\Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA 		abnormal CD4-positive T cell differentiation J:204829
\Myf5tm3(cre)Sor/\Myf5+
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N 		decreased body length J:119237
decreased body weight J:119237
decreased circulating insulin-like growth factor I level J:119237
decreased lean body mass J:119237
increased total body fat amount J:119237
\Nr3c1tm2Gsc/\Nr3c1tm2Gsc
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N 		decreased body weight J:121556
\Stat5atm1.1Wjl/\Stat5atm1.1Wjl
\Stat5btm2.1Wjl/\Stat5btm2.1Wjl
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal leukocyte morphology J:187325
abnormal regulatory T cell physiology J:187325
abnormal T cell subpopulation ratio J:187325
decreased CD8-positive, alpha-beta T cell number J:187325
decreased erythrocyte cell number J:187325
decreased hematocrit J:187325
decreased hemoglobin content J:187325
decreased NK cell number J:187325
decreased T cell proliferation J:187325
increased T cell apoptosis J:187325
\Stat5atm1Jni/\Stat5atm1Jni
\Stat5btm2Jni/\Stat5btm2Jni
either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ) 		abnormal fat pad morphology J:77412
abnormal liver physiology J:77412
abnormal myelopoiesis J:77412
decreased body weight J:77412
decreased corpora lutea number J:77412
decreased leukocyte cell number J:77412
decreased T cell number J:77412
female infertility J:77412
increased neutrophil cell number J:77412
\Stat5atm1Jni/\Stat5atm1Jni
\Stat5btm2Jni/\Stat5btm2Jni
involves: 129 * C57BL/6 		abnormal mast cell differentiation J:84889
abnormal mast cell physiology J:84889
absent mast cells J:84889
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:122463
premature death J:122463
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5b+
involves: 129S6/SvEvTac 		abnormal lymphopoiesis J:258967
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
involves: 129S6/SvEvTac * Black Swiss 		no abnormal phenotype detected J:92770
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Myf5tm3(cre)Sor/\Myf5+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		decreased body length J:119237
decreased body weight J:119237
decreased circulating insulin-like growth factor I level J:119237
decreased lean body mass J:119237
impaired glucose tolerance J:119237
increased circulating triglyceride level J:119237
increased total body fat amount J:119237
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Alb1-cre)7Gsc/0
involves: 129S6/SvEvTac * FVB/N 		decreased body weight J:121556
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 		increased circulating interleukin-17 level J:120176
increased interleukin-17 secretion J:120176
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA 		decreased insulin secretion J:127051
disorganized pancreatic islets J:127051
impaired glucose tolerance J:127051
increased circulating free fatty acids level J:127051
increased circulating glucose level J:127051
increased circulating leptin level J:127051
increased total body fat amount J:127051
obese J:127051
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Lck-cre)I57Jxm/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR 		abnormal acute inflammation J:122463
abnormal T cell subpopulation ratio J:122463
decreased CD8-positive, alpha-beta T cell number J:122463
enlarged spleen J:122463
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(MMTV-cre)1Mam/0
involves: 129S6/SvEvTac * FVB/N 		abnormal mammary gland alveolus morphology J:153755
abnormal mammary gland growth during lactation J:153755
lactation failure J:153755
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(MMTV-cre)1Mam/0
\Tg(MMTV-rtTA)1Lach/0
\Tg(tetO-Stat5a)#Mam/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		normal endocrine/exocrine gland phenotype J:153755
normal reproductive system phenotype J:153755
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB 		abnormal branching of the mammary ductal tree J:92770
abnormal milk ejection J:92770
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal leukopoiesis J:155489
abnormal neutrophil differentiation J:155489
abnormal neutrophil physiology J:155489
anemia J:155489
decreased cell proliferation J:155489
decreased erythrocyte cell number J:155489
decreased hematocrit J:155489
decreased hemoglobin content J:155489
decreased leukocyte cell number J:155489
decreased lymphocyte cell number J:155489
decreased monocyte cell number J:155489
decreased neutrophil cell number J:155489
increased apoptosis J:155489
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Nes-cre)1Kln/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal fat pad morphology J:132806
decreased oxygen consumption J:132806
impaired adaptive thermogenesis J:132806
impaired glucose tolerance J:132806
increased circulating free fatty acids level J:132806
increased circulating insulin level J:132806
increased circulating leptin level J:132806
increased circulating triglyceride level J:132806
increased lean body mass J:132806
increased percent body fat/body weight J:132806
increased total body fat amount J:132806
increased total fat pad weight J:132806
insulin resistance J:132806
obese J:132806
polyphagia J:132806
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Pdx1-cre)89.1Dam/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		disorganized pancreatic islets J:127051
impaired glucose tolerance J:127051
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal proerythroblast morphology J:138904
anisocytosis J:138904
decreased erythrocyte cell number J:138904
decreased erythroid progenitor cell number J:138904
decreased hematocrit J:138904
decreased mean corpuscular hemoglobin J:138904
hypochromic microcytic anemia J:138904
increased apoptosis J:138904
increased circulating iron level J:138904
increased liver iron level J:138904
increased red blood cell distribution width J:138904
microcytosis J:138904
poikilocytosis J:138904
reticulocytosis J:138904
\Stat5atm2Mam/\Stat5atm2Mam
\Stat5btm1Mam/\Stat5btm1Mam
\Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss 		abnormal mammary gland alveolus morphology J:92770
abnormal mammary gland epithelium physiology J:92770
increased mammary gland apoptosis J:92770
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory