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Plau Gene Detail
Summary
  • Symbol
    Plau
  • Name
    plasminogen activator, urokinase
  • Synonyms
    u-PA, uPA, urokinase-type plasminogen activator
  • Feature Type
    protein coding gene
  • IDs
    MGI:97611
    NCBI Gene: 18792
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20886728-20893453 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    41 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    7
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97611
 protein coding gene Chr14:20886728-20893456 (+)
129S1/SvImJ ENSMUSG00200015109
 protein coding gene Chr14:12673159-12679892 (+)
A/J ENSMUSG00195020925
 protein coding gene Chr14:13759308-13766038 (+)
AKR/J ENSMUSG00220026073
 protein coding gene Chr14:12889859-12896591 (+)
BALB/cJ ENSMUSG00180034184
 protein coding gene Chr14:12853594-12860309 (+)
C3H/HeJ ENSMUSG00175022250
 protein coding gene Chr14:12915209-12921938 (+)
C57BL/6NJ ENSMUSG00215028339
 protein coding gene Chr14:13104839-13111567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019001
 protein coding gene Chr14:13610438-13616223 (+)
CAST/EiJ ENSTCUG00005028294
 protein coding gene Chr14:13031439-13038174 (+)
CBA/J ENSMUSG00210025223
 protein coding gene Chr14:13146247-13152992 (+)
DBA/2J ENSMUSG00185037932
 protein coding gene Chr14:17431319-17438062 (+)
FVB/NJ ENSMUSG00205031957
 protein coding gene Chr14:12988298-12995034 (+)
JF1/MsJ ENSUMUG00000037726
 protein coding gene Chr14:24648144-24654861 (+)
LP/J ENSMUSG00230037708
 protein coding gene Chr14:24713108-24719841 (+)
NOD/ShiLtJ ENSMUSG00190034308
 protein coding gene Chr14:13145171-13151911 (+)
NZO/HlLtJ ENSMUSG00225035432
 protein coding gene Chr14:18948051-18954790 (+)
PWK/PhJ ENSLUMG00010021138
 protein coding gene Chr14:1219598-1226336 (+)
SPRET/EiJ ENSMSPG00010025845
 protein coding gene Chr14:14769871-14776599 (+)
WSB/EiJ ENSIUOG00005032336
 protein coding gene Chr14:12962191-12968885 (+)



Homology
more
  • Human Ortholog
    PLAU, plasminogen activator, urokinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAU, plasminogen activator, urokinase
  • Synonyms
    ATF, BDPLT5, QPD, u-PA, UPA, URK
  • Links
    NCBI Gene ID: 5328
    UniProt: P00749

  • Chr Location
    10q22.2; chr10:73908832-73917501 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Plau mouse models; 13 with human PLAU associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    86 phenotypes from 6 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    215 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury. They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy. Homozygosity for an ASD-related mutation increases enzymatic activity, which leads to increased anxiety and impaired social behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    244
  • cDNA Data
    16
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021822 Ensembl Gene Model | MGI Sequence Detail 6726 C57BL/6J ±  kb
    transcript ENSMUST00000022368 Ensembl | MGI Sequence Detail 2342 Not Applicable  
    polypeptide ENSMUSP00000022368 Ensembl | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 17
      Primer pair 9
      Other 3
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13347
    References
    more
    • Summaries
      All 361
      Developmental Gene Expression 29
      Diseases 2
      Gene Ontology 19
      Phenotypes 215
    • Earliest
      J:7809 Belin D, et al., Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem. 1985 Apr 15;148(2):225-32
    • Latest
      J:388086 Li X, et al., Activated ATF6alpha is a hepatic tumour driver restricting immunosurveillance. Nature. 2026 Mar;651(8106):796-807
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory