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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Plau
plasminogen activator, urokinase
MGI:97611
80 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Plautm1.1Bug/Plautm1.1Bug
involves: C57BL/6
chronic inflammation J:164542
decreased physiological sensitivity to xenobiotic J:164542
normal homeostasis/metabolism phenotype J:164542
liver fibrosis J:164542
liver inflammation J:164542
trachea inflammation J:164542
Plautm1b(EUCOMM)Wtsi/Plautm1b(EUCOMM)Wtsi
C57BL/6N-Plautm1b(EUCOMM)Wtsi/H
decreased exploration in new environment J:211773
decreased grip strength J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
Plautm1Mlg/Plautm1Mlg
B6.129S2-Plautm1Mlg
abnormal response to injury J:164542
abnormal trachea morphology J:164542
cachexia J:164542
chronic inflammation J:164542
decreased liver glycogen level J:164542
decreased total body fat amount J:164542
increased inflammatory response J:164542
liver fibrosis J:164542
liver inflammation J:164542
premature death J:164542
trachea fibrosis J:164542
trachea inflammation J:164542
Plautm1Mlg/Plautm1Mlg
B6.Cg-Plautm1Mlg
abnormal acute phase protein level J:68083
abnormal cytokine level J:75303
abnormal perineum morphology J:73613
abnormal rectum morphology J:73613
abnormal tumor morphology J:65383
decreased inflammatory response J:68083
decreased metastatic potential J:65383
decreased susceptibility to induced arthritis J:75303
decreased T cell proliferation J:75303
decreased tumor growth/size J:65383
herniated seminal vesicle J:73613
impaired macrophage chemotaxis J:68083
impaired skeletal muscle regeneration J:68083
myopathy J:73613
rectal prolapse J:73613
Plautm1Mlg/Plautm1Mlg
either: B6.Cg-Plautm1Mlg or (involves: Black Swiss * C57BL/6)
reduced thrombolysis J:64220
Plautm1Mlg/Plautm1Mlg
involves: 129S2/SvPas * C57BL/6
abnormal acute phase protein level J:63134, J:82604
abnormal cell-mediated immunity J:87817, J:95638
abnormal circulating protein level J:104962
abnormal eyelid morphology J:17427
abnormal facial skin morphology J:17427
abnormal macrophage physiology J:17427
abnormal neutrophil physiology J:75573, J:91980
abnormal outer ear skin morphology J:17427
abnormal thrombosis J:17427
cardiac interstitial fibrosis J:95236
decreased susceptibility to induced choroidal neovascularization J:82604
normal growth/size/body region phenotype J:17427
heart left ventricle hypertrophy J:95236
normal hematopoietic system phenotype J:17427
impaired granulocyte bactericidal activity J:91980
impaired macrophage chemotaxis J:63134
impaired neutrophil phagocytosis J:91980
increased lymphocyte cell number J:63134
increased susceptibility to fungal infection J:95637
increased susceptibility to induced thrombosis J:17427
increased susceptibility to parasitic infection J:87817
increased ventricle muscle contractility J:95236
normal mortality/aging J:17427
normal nervous system phenotype J:55243, J:104962
pulmonary interstitial fibrosis J:63134
rectal prolapse J:17427
normal reproductive system phenotype J:17427
Tg(MSR1-Plau)1Ddi/0
involves: C57BL/6 * SJL
cardiac fibrosis J:101486
enlarged heart J:101486
heart inflammation J:101486
Tg(Mup3-Plau)350-2Eps/?
C57BL/6-Tg(Mup3-Plau)350-2Eps
abnormal circulating alanine transaminase level J:233146
abnormal endoplasmic reticulum morphology J:233146
abnormal hepatocyte morphology J:233146
hepatic necrosis J:233146
hepatic steatosis J:233146
increased hepatocellular carcinoma incidence J:233146
increased hepatocyte apoptosis J:233146
increased interleukin-1 beta secretion J:233146
increased liver adenoma incidence J:233146
increased liver cholesterol level J:233146
increased liver free fatty acids level J:233146
increased liver triglyceride level J:233146
increased liver tumor incidence J:233146
increased tumor necrosis factor secretion J:233146
liver fibrosis J:233146
liver hyperplasia J:233146
liver inflammation J:233146
Tg(Mup3-Plau)350-2Eps/0
involves: C57BL/6
normal cardiovascular system phenotype J:66132
increased circulating alanine transaminase level J:66132
increased liver tumor incidence J:66132
pale liver J:66132
Tg(Mup3-Plau)350-2Eps/0
involves: C57BL/6 * FVB/N
subcutaneous edema J:66132

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory