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Targeted Allele Detail
Symbol: Plautm1Mlg
Name: plasminogen activator, urokinase; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:1857289
Synonyms: u-PA-, uPA-, UPA-
Gene: Plau  Location: Chr14:20886728-20893453 bp, + strand  Genetic Position: Chr14, 11.53 cM
Alliance: Plautm1Mlg page
Germline Transmission:  Earliest citation of germline transmission: J:17427
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encompassing all but 23 amino acids of the coding sequence. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 16 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Plautm1Mlg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Plau Mutation:  28 strains or lines available
Original:  J:17427 Carmeliet P, et al., Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31;368(6470):419-24
All:  133 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory