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H2-Ea Pseudogene Detail
Summary
  • Symbol
    H2-Ea
  • Name
    histocompatibility 2, class II antigen E alpha
  • Synonyms
    H-2Ea, H2-Ea-ps, Ia-3, Ia3, I-Ealpha
Location &
Maps
more
  • Sequence Map
    Chr17:34560926-34563618 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    42
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95900
 polymorphic pseudogene Chr17:34560926-34563619 (-)
129S1/SvImJ ENSMUSG00200048029
 protein coding gene Chr17:30265036-30266747 (-)
A/J ENSMUSG00195033359
 protein coding gene Chr17:31131203-31132911 (-)
AKR/J ENSMUSG00220047673
 protein coding gene Chr17:30158835-30160542 (-)
BALB/cJ ENSMUSG00180034258
 protein coding gene Chr17:30514923-30516634 (-)
C3H/HeJ ENSMUSG00175053188
 protein coding gene Chr17:30044987-30046694 (-)
C57BL/6NJ ENSMUSG00215052202
 protein coding gene Chr17:30105214-30106925 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0037187
 pseudogene Chr17:31153519-31155221 (-)
CAST/EiJ ENSTCUG00005050194
 protein coding gene Chr17:31087355-31089053 (-)
CBA/J ENSMUSG00210043678
 protein coding gene Chr17:29867095-29868802 (-)
DBA/2J ENSMUSG00185054047
 protein coding gene Chr17:32534211-32535922 (-)
FVB/NJ ENSMUSG00205021000
 protein coding gene Chr17:30381806-30383506 (-)
JF1/MsJ ENSUMUG00000046205
 protein coding gene Chr17:31801767-31803467 (-)
LP/J ENSMUSG00230054089
 protein coding gene Chr17:33663347-33665058 (-)
NOD/ShiLtJ ENSMUSG00190052554
 protein coding gene Chr17:30013195-30014909 (-)
NZO/HlLtJ ENSMUSG00225049322
 protein coding gene Chr17:35697034-35698737 (-)
PWK/PhJ ENSLUMG00010043089
 protein coding gene Chr17:29650679-29652390 (-)
SPRET/EiJ ENSMSPG00010037883
 protein coding gene Chr17:30791662-30793369 (-)
WSB/EiJ ENSIUOG00005048231
 protein coding gene Chr17:30718749-30720452 (-)



Homology
more
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Synonyms
    HLA-DRA1
  • Links
    NCBI Gene ID: 3122
    UniProt: P01903

  • Chr Location
    6p21.32; chr6:32439872-32445047 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human HLA-DRA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from multigenic genotypes
    282 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
Sequences &
Gene Models
less
  • All Sequences
    47
  • RefSeq
    3
  • UniProt
    6
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036322 Ensembl Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
transcript ENSMUST00000134042 Ensembl | MGI Sequence Detail 1042 Not Applicable  
polypeptide ENSMUSP00000158275 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 52
    cDNA 8
    Primer pair 2
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10383, MGD-MRK-10496, MGD-MRK-11046, MGD-MRK-11051, MGI:2146825, MGI:6360898
References
more
  • Summaries
    All 359
    Diseases 1
    Gene Ontology 9
    Phenotypes 282
  • Earliest
    J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
  • Latest
    J:391774 Pineda JE, et al., Antigen presentation requirements for effective cDC1-based cancer immunotherapy. J Immunol. 2026 Aug 4;215(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory