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Cntf Gene Detail
Summary
  • Symbol
    Cntf
  • Name
    ciliary neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88439
    NCBI Gene: 12803
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:12741024-12742996 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.73 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88439
 protein coding gene Chr19:12740892-12742996 (-)
129S1/SvImJ ENSMUSG00200050028
 protein coding gene Chr19:9431628-9433600 (-)
A/J ENSMUSG00195048871
 protein coding gene Chr19:9564725-9566697 (-)
AKR/J ENSMUSG00220048171
 protein coding gene Chr19:9541655-9543627 (-)
BALB/cJ ENSMUSG00180042916
 protein coding gene Chr19:9929302-9931274 (-)
C3H/HeJ ENSMUSG00175008920
 protein coding gene Chr19:9280152-9282124 (-)
C57BL/6NJ ENSMUSG00215035750
 protein coding gene Chr19:9342390-9344362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022764
 protein coding gene Chr19:10232872-10234846 (-)
CAST/EiJ ENSTCUG00005025842
 protein coding gene Chr19:9126933-9128904 (-)
CBA/J ENSMUSG00210048557
 protein coding gene Chr19:9478619-9480591 (-)
DBA/2J ENSMUSG00185050181
 protein coding gene Chr19:9888729-9890701 (-)
FVB/NJ ENSMUSG00205033581
 protein coding gene Chr19:9318887-9320859 (-)
JF1/MsJ ENSUMUG00000054862
 protein coding gene Chr19:9973679-9975643 (-)
LP/J ENSMUSG00230017718
 protein coding gene Chr19:10799288-10801260 (-)
NOD/ShiLtJ ENSMUSG00190034820
 protein coding gene Chr19:9289215-9291187 (-)
NZO/HlLtJ ENSMUSG00225043315
 protein coding gene Chr19:14508308-14510280 (-)
PWK/PhJ ENSLUMG00010004139
 protein coding gene Chr19:9384987-9386955 (-)
SPRET/EiJ ENSMSPG00010048828
 protein coding gene Chr19:9328851-9330813 (-)
WSB/EiJ ENSIUOG00005050237
 protein coding gene Chr19:8983511-8985483 (-)



Homology
more
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Synonyms
    HCNTF
  • Links
    NCBI Gene ID: 1270
    UniProt: P26441

  • Chr Location
    11q12.1; chr11:58622665-58625733 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CNTF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display progressive atrophy and degeneration of motor neurons in adulthood and reduced muscle strength. Another allele does not display any overt abnormalities at birth, however motor neuron sprouting does not occur after damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    76
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    122
  • cDNA Data
    7
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079415 Ensembl Gene Model | MGI Sequence Detail 1973 C57BL/6J ±  kb
    transcript ENSMUST00000112933 Ensembl | MGI Sequence Detail 1073 Not Applicable  
    polypeptide ENSMUSP00000108555 Ensembl | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 10
      Primer pair 4
      Other 1
      Antibodies 1
    Other
    Accession IDs
    less
    MGD-MRK-2043, MGI:2147531
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 47
    • Earliest
      J:14942 Kaupmann K, et al., The gene for ciliary neurotrophic factor (CNTF) maps to murine Chromosome 19 and its expression is not affected in the hereditary motoneuron disease 'Wobbler' of the mouse. Eur J Neurosci. 1991;3:1182-86
    • Latest
      J:385450 Cox D, et al., FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF. Stem Cells. 2026 Mar 26;44(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory