Lrit2 Gene Detail

Summary

• Symbol
  Lrit2
• Name
  leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
• Synonyms
  A930010E21Rik, Lrrc22

• Feature Type
  protein coding gene
• IDs
  MGI:2444885
  NCBI Gene: 239038
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr14:36789886-36795700 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 21.29 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  112 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444885	protein coding gene	Chr14:36784923-36795700 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021186	protein coding gene	Chr14:30569018-30574639 (+)
A/J	MGP_AJ_G0021134	protein coding gene	Chr14:29303733-29309888 (+)
AKR/J	MGP_AKRJ_G0021111	protein coding gene	Chr14:30641702-30647292 (+)
BALB/cJ	MGP_BALBcJ_G0021138	protein coding gene	Chr14:29535376-29541979 (+)
C3H/HeJ	MGP_C3HHeJ_G0020921	protein coding gene	Chr14:30523879-30529511 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021570	protein coding gene	Chr14:31665595-31671179 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019132	protein coding gene	Chr14:29288179-29294050 (+)
CAST/EiJ	MGP_CASTEiJ_G0020446	protein coding gene	Chr14:30410573-30416919 (+)
CBA/J	MGP_CBAJ_G0020887	protein coding gene	Chr14:32846343-32853489 (+)
DBA/2J	MGP_DBA2J_G0021010	protein coding gene	Chr14:29344838-29350452 (+)
FVB/NJ	MGP_FVBNJ_G0020994	protein coding gene	Chr14:29321847-29327528 (+)
LP/J	MGP_LPJ_G0021079	protein coding gene	Chr14:30862651-30869905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021020	protein coding gene	Chr14:32049347-32055956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021603	protein coding gene	Chr14:30503628-30509246 (+)
PWK/PhJ	MGP_PWKPhJ_G0020194	protein coding gene	Chr14:28887714-28894522 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020018	protein coding gene	Chr14:30050979-30057854 (+)
WSB/EiJ	MGP_WSBEiJ_G0020501	protein coding gene	Chr14:30529934-30535768 (+)

Homology

• Human Ortholog
  LRIT2, leucine rich repeat, Ig-like and transmembrane domains 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRIT2, leucine rich repeat, Ig-like and transmembrane domains 2
  
• Synonyms
  LRRC22
• Links
  HGNC:23443

  NCBI Gene ID: 340745

  neXtProt AC: NX_A6NDA9

  UniProt: A6NDA9

  
  
• Chr Location
  10q23.1; chr10:84220485-84225589 (-)  GRCh38

---

• Alliance of Genome Resources
  Lrit2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LRIT2
• Gene Tree
  Lrit2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Targeted
  1
• Genomic Mutations
  1 involving Lrit2
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  16 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  727
• Tissues
  17
• cDNA Data
  15
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lrit2
  ZFIN lrit2

Interactions

• Lrit2 interacts with 147 markers (Mir1a-1, Mir1a-2, Mir15a, ...) View All

Sequences &
Gene Models

• All Sequences
  37
• RefSeq
  8
• UniProt
  1
• CCDS
  CCDS26951.1

• Ensembl
  ENSMUSG00000043418 (Evidence)
• NCBI Gene
  239038

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000043418	Ensembl Gene Model | MGI Sequence Detail	5815	C57BL/6J
transcript	ENSMUST00000057176	Ensembl | MGI Sequence Detail	2790	Not Applicable
polypeptide	ENSMUSP00000056642	Ensembl | MGI Sequence Detail	549	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000032750 leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
  (term hierarchy)
• InterPro Domains
  IPR000483 Cysteine-rich flanking region, C-terminal
  IPR036116 Fibronectin type III superfamily
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain superfamily
  IPR003591 Leucine-rich repeat, typical subtype

Molecular
Reagents

• All nucleic 17

  cDNA 15

  Primer pair 1

  Other 1

  
  

  Microarray probesets 2

References

• Summaries
  All 22

  Developmental Gene Expression 3

  Gene Ontology 1

  Phenotypes 2
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:271244 Ueno A, et al., Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018 Mar 27;22(13):3548-3561

TSS for Lrit2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125115	Chr14:36789970-36789981 (+)	90 bp
Tssr125116	Chr14:36789999-36790011 (+)	119 bp
Tssr125117	Chr14:36790014-36790021 (+)	132 bp