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Grhl2 Gene Detail
Summary
  • Symbol
    Grhl2
  • Name
    grainyhead like transcription factor 2
  • Synonyms
    0610015A08Rik, BOM, clft3, grainyheadlike, Tcfcp2l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182543
    NCBI Gene: 252973
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37233280-37363813 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.84 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3995 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182543
 protein coding gene Chr15:37233065-37363813 (+)
129S1/SvImJ ENSMUSGG00200054569
 protein coding gene Chr15:34233566-34334928 (+)
A/J ENSMUSGG00195055464
 protein coding gene Chr15:34159516-34260292 (+)
AKR/J ENSMUSGG00220054856
 protein coding gene Chr15:34073490-34174268 (+)
BALB/cJ ENSMUSGG00180055348
 protein coding gene Chr15:34134113-34234805 (+)
C3H/HeJ ENSMUSGG00175054790
 protein coding gene Chr15:34338393-34439025 (+)
C57BL/6NJ ENSMUSGG00215055528
 protein coding gene Chr15:34146257-34246912 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019744
 protein coding gene Chr15:32106514-32238701 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054857
 protein coding gene Chr15:34252835-34353502 (+)
DBA/2J ENSMUSGG00185057332
 protein coding gene Chr15:34233665-34334328 (+)
FVB/NJ ENSMUSGG00205054376
 protein coding gene Chr15:34128438-34229184 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055294
 protein coding gene Chr15:37614728-37716093 (+)
NOD/ShiLtJ ENSMUSGG00190054756
 protein coding gene Chr15:34202257-34302955 (+)
NZO/HlLtJ ENSMUSGG00225055457
 protein coding gene Chr15:37925080-38025741 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GRHL2, grainyhead like transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRHL2, grainyhead like transcription factor 2
  • Synonyms
    BOM, DFNA28, ECTDS, PPCD4, TFCP2L3
  • Links
    NCBI Gene ID: 79977
    UniProt: Q6ISB3

  • Chr Location
    8q22.3; chr8:101492439-101681200 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GRHL2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 7 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1270
  • Tissues
    372
  • cDNA Data
    44
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022286 Ensembl Gene Model | MGI Sequence Detail 130534 C57BL/6J ±  kb
    transcript ENSMUST00000022895 Ensembl | MGI Sequence Detail 4947 Not Applicable  
    polypeptide ENSMUSP00000022895 Ensembl | MGI Sequence Detail 625 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 47
      Primer pair 6
      Other 1
      Antibodies 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915242, MGI:5056362
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 37
      Gene Ontology 16
      Phenotypes 34
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory