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Dock8 Gene Detail
Summary
  • Symbol
    Dock8
  • Name
    dedicator of cytokinesis 8
  • Synonyms
    1200017A24Rik, 5830472H07Rik, A130095G14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921396
    NCBI Gene: 76088
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24976898-25179796 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 19.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921396
 protein coding gene Chr19:24976753-25179796 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025000
 protein coding gene Chr19:23264270-23480849 (+)
A/J MGP_AJ_G0024977
 protein coding gene Chr19:21975811-22191729 (+)
AKR/J MGP_AKRJ_G0024945
 protein coding gene Chr19:22802201-23013167 (+)
BALB/cJ MGP_BALBcJ_G0024976
 protein coding gene Chr19:22036837-22244112 (+)
C3H/HeJ MGP_C3HHeJ_G0024732
 protein coding gene Chr19:22791745-23007928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025417
 protein coding gene Chr19:23974213-24197974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022836
 protein coding gene Chr19:22137232-22341303 (+)
CAST/EiJ MGP_CASTEiJ_G0024202
 protein coding gene Chr19:22535379-22754533 (+)
CBA/J MGP_CBAJ_G0024710
 protein coding gene Chr19:24974646-25217720 (+)
DBA/2J MGP_DBA2J_G0024842
 protein coding gene Chr19:21983056-22193229 (+)
FVB/NJ MGP_FVBNJ_G0024804
 protein coding gene Chr19:21887362-22094718 (+)
LP/J MGP_LPJ_G0024927
 protein coding gene Chr19:23205245-23418729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024831
 protein coding gene Chr19:25047000-25268355 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025472
 protein coding gene Chr19:22831581-23045795 (+)
PWK/PhJ MGP_PWKPhJ_G0023950
 protein coding gene Chr19:21605888-21816941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023755
 protein coding gene Chr19:22081413-22294428 (+)
WSB/EiJ MGP_WSBEiJ_G0024269
 protein coding gene Chr19:22851201-23076259 (+)



Homology
more
  • Human Ortholog
    DOCK8, dedicator of cytokinesis 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK8, dedicator of cytokinesis 8
  • Synonyms
    HEL-205, HIES2, MRD2, ZIR8
  • Links
    NCBI Gene ID: 81704
    neXtProt AC: NX_Q8NF50
    UniProt: Q8NF50

  • Chr Location
    9p24.3; chr9:211257-465259 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human DOCK8 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 9 alleles in 11 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    28
  • cDNA Data
    59
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052085 Ensembl Gene Model | MGI Sequence Detail 202899 C57BL/6J ±  kb
    transcript ENSMUST00000025831 Ensembl | MGI Sequence Detail 7805 Not Applicable  
    polypeptide ENSMUSP00000025831 Ensembl | MGI Sequence Detail 2100 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 61
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923338, MGI:2147551, MGI:2443467
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 39
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:322122 Shiozawa S, et al., DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus. iScience. 2022 Jan 21;25(1):103537
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory