Dock8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dock8
dedicator of cytokinesis 8
MGI:1921396

29 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dock8^cpm/Dock8^cpm C57BL/6JSfdAnu-Dock8^cpm	abnormal humoral immune response	J:155516
	decreased marginal zone B cell number	J:155516
	decreased spleen germinal center size	J:155516
	decreased T cell number	J:155516
Dock8^cpm/Dock8^pri C57BL/6J-Dock8^cpm/Dock8^pri	decreased marginal zone B cell number	J:155516
Dock8^cpm/Dock8^pri C57BL/6J-Dock8^cpm/Dock8^pri	decreased T cell number	J:155516
Dock8^m1Anu/Dock8^m1Anu C57BL/6NCrlAnu-Dock8^m1Anu	decreased activated T cell number	J:104190
	decreased IgM level	J:104190
	decreased T cell number	J:104190
Dock8^m1Btlr/Dock8^m1Btlr C57BL/6J-Dock8^m1Btlr	decreased IgG level	J:234247
Dock8^m1Btlr/Dock8^m1Btlr C57BL/6J-Dock8^m1Btlr	impaired humoral immune response	J:234247
Dock8^m2Anu/Dock8^m2Anu C57BL/6NCrlAnu-Dock8^m2Anu	absent marginal zone B cells	J:104190
	decreased activated T cell number	J:104190
	decreased IgM level	J:104190
	decreased T cell number	J:104190
Dock8^M2Btlr/Dock8^M2Btlr C57BL/6J-Dock8^M2Btlr	decreased CD8-positive, alpha-beta T cell number	J:272530
Dock8^M3Btlr/Dock8^M3Btlr C57BL/6J-Dock8^M3Btlr	decreased IgG level	J:272531
Dock8^M3Btlr/Dock8^M3Btlr C57BL/6J-Dock8^M3Btlr	impaired humoral immune response	J:272531
Dock8^m4Btlr/Dock8^m4Btlr C57BL/6J-Dock8^m4Btlr	abnormal B cell differentiation	J:274856
	abnormal CD4-positive T cell differentiation	J:274856
	abnormal CD8-positive, alpha-beta T cell differentiation	J:274856
	abnormal T cell differentiation	J:274856
	decreased B-1 B cell number	J:274856
	decreased CD4-positive, alpha-beta T cell number	J:274856
	decreased CD8-positive, alpha-beta T cell number	J:274856
	decreased CD8-positive, naive alpha-beta T cell number	J:274856
	decreased T cell number	J:274856
	increased CD4-positive, alpha-beta T cell number	J:274856
	increased central memory CD4-positive, alpha-beta T cell number	J:274856
	increased central memory CD8 positive, alpha-beta T cell number	J:274856
	increased effector memory CD4-positive, alpha-beta T cell number	J:274856
	increased effector memory CD8-positive, alpha-beta T cell number	J:274856
Dock8^pri/Dock8^pri C57BL/6JAnu-Dock8^pri	abnormal humoral immune response	J:155516
	decreased B-1 B cell number	J:155516
	decreased germinal center B cell number	J:155516
	decreased marginal zone B cell number	J:155516
	decreased spleen germinal center size	J:155516
	decreased T cell number	J:155516
Dock8^pri/Dock8^pri involves: C57BL/6JAnu	abnormal cellular extravasation	J:238772
	abnormal myelination	J:238772
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:238772
Dock8^tm1Ysfk/Dock8^tm1Ysfk B6.Cg-Dock8^tm1Ysfk	abnormal dendritic cell physiology	J:185165
	decreased CD4-positive, alpha-beta T cell number	J:185165
	decreased CD8-positive, alpha-beta T cell number	J:185165
	decreased follicular dendritic cell number	J:185165
	decreased IgG level	J:185165
	decreased marginal zone B cell number	J:185165
	decreased T cell proliferation	J:185165

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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