Dock8^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock8^m4Btlr
• Name: dedicator of cytokinesis 8; mutation 4, Bruce Beutler
• MGI ID: MGI:6305076
• Synonyms: warts_and_all
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 25,169,501 (v38) on chromosome 19, or base pair 16,9991 in the GenBank genomic region NC_000085 in the splice donor site of intron 34, two-base pairs from exon 34. The effect of the mutation at the cDNA and protein levels have not examined, but the mutation is predicted to result in skipping of the 97-base pair exon 34 (out of 48 total exons). The mutation would cause a frame-shifted protein product beginning after amino acid 1,415 of the protein, which is normally 2,100 amino acids in length, and termination after the inclusion of 19 aberrant amino acids. (J:274856)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

References

• Original: J:274856 Zhong X, et al., Mutagenetix entry for warts_and_all. MGI Direct Data Submission. 2019
• All: 1 reference(s)