Phenotypes associated with this allele

• Allele Symbol: Dock8^m4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:6305076
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock8^m4Btlr/Dock8^m4Btlr	C57BL/6J-Dock8^m4Btlr	MGI:6305078

Genotype
MGI:6305078

hm1

• Allelic Composition: Dock8^m4Btlr/Dock8^m4Btlr
• Genetic Background: C57BL/6J-Dock8^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:274856 )

• reduced expression of B220 on peripheral blood B cells

• increased peripheral blood B to T cell ratios

abnormal T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood CD8+ T cells

decreased B-1 B cell number ( J:274856 )

• reduced frequencies of B1 cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274856 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274856 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274856 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274856 )

• reduced frequencies of CD8+ T cells in the peripheral blood

hematopoietic system

abnormal B cell differentiation ( J:274856 )

• reduced expression of B220 on peripheral blood B cells

• increased peripheral blood B to T cell ratios

abnormal T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274856 )

• increased expression of CD44 on peripheral blood CD8+ T cells

decreased B-1 B cell number ( J:274856 )

• reduced frequencies of B1 cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274856 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274856 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274856 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274856 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274856 )

• reduced frequencies of CD8+ T cells in the peripheral blood