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Hs6st1 Gene Detail
Summary
  • Symbol
    Hs6st1
  • Name
    heparan sulfate 6-O-sulfotransferase 1
  • Synonyms
    6OST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354958
    NCBI Gene: 50785
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36107481-36145527 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.15 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    431 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354958
protein coding gene Chr1:36107481-36145527 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015917
protein coding gene Chr1:34566709-34606731 (+)
A/J MGP_AJ_G0015901
protein coding gene Chr1:33653757-33691652 (+)
AKR/J MGP_AKRJ_G0015856
protein coding gene Chr1:34133645-34171576 (+)
BALB/cJ MGP_BALBcJ_G0015855
protein coding gene Chr1:33346418-33384704 (+)
C3H/HeJ MGP_C3HHeJ_G0015688
protein coding gene Chr1:34316726-34357738 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016308
protein coding gene Chr1:36139091-36183032 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014030
protein coding gene Chr1:30718109-30755143 (+)
CAST/EiJ MGP_CASTEiJ_G0015269
protein coding gene Chr1:34196270-34239772 (+)
CBA/J MGP_CBAJ_G0015660
protein coding gene Chr1:37068670-37112237 (+)
DBA/2J MGP_DBA2J_G0015761
protein coding gene Chr1:32994312-33032731 (+)
FVB/NJ MGP_FVBNJ_G0015763
protein coding gene Chr1:32510045-32548781 (+)
LP/J MGP_LPJ_G0015831
protein coding gene Chr1:34936444-34976212 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015783
protein coding gene Chr1:39336105-39376494 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016355
protein coding gene Chr1:34134151-34174301 (+)
PWK/PhJ MGP_PWKPhJ_G0015052
protein coding gene Chr1:32735580-32773805 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014834
protein coding gene Chr1:34112674-34150022 (+)
WSB/EiJ MGP_WSBEiJ_G0015331
protein coding gene Chr1:34105936-34146836 (+)



Homology
more
  • Human Ortholog
    HS6ST1, heparan sulfate 6-O-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS6ST1, heparan sulfate 6-O-sulfotransferase 1
  • Synonyms
    HH15, HS6ST
  • Links
    NCBI Gene ID: 9394
    neXtProt AC: NX_O60243
    UniProt: O60243

  • Chr Location
    2q14.3; chr2:128236716-128318868 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human HS6ST1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show prenatal loss, stunted growth, dilated alveoli and lower postweaning survival. Homozygotes for another null allele show additional defects in placenta, eye, phalanx and tarsus morphology. Homozygotes for a gene trapallele show altered retinal axon guidance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50785 NCBI Gene Model | MGI Sequence Detail 38047 C57BL/6J ±  kb
    transcript NM_015818 RefSeq | MGI Sequence Detail 3732 C57BL/6  
    polypeptide Q9QYK5 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 100
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 20
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
    • Latest
      J:333815 Tao C, et al., Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate. Development. 2022 Jun 15;149(12):dev200569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory