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Gdf11 Gene Detail
Summary
  • Symbol
    Gdf11
  • Name
    growth differentiation factor 11
  • Synonyms
    Bmp11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338027
    NCBI Gene: 14561
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128718164-128727587 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.18 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338027
 protein coding gene Chr10:128716393-128727587 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017887
 protein coding gene Chr10:132682001-132691242 (-)
A/J MGP_AJ_G0017862
 protein coding gene Chr10:127337362-127346748 (-)
AKR/J MGP_AKRJ_G0017825
 protein coding gene Chr10:131054406-131063817 (-)
BALB/cJ MGP_BALBcJ_G0017826
 protein coding gene Chr10:127698599-127708010 (-)
C3H/HeJ MGP_C3HHeJ_G0017649
 protein coding gene Chr10:131226106-131237151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018281
 protein coding gene Chr10:137149770-137159086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015959
 protein coding gene Chr10:121248717-121258076 (-)
CAST/EiJ MGP_CASTEiJ_G0017210
 protein coding gene Chr10:131919429-131964741 (-)
CBA/J MGP_CBAJ_G0017619
 protein coding gene Chr10:142746040-142755456 (-)
DBA/2J MGP_DBA2J_G0017725
 protein coding gene Chr10:126396079-126405502 (-)
FVB/NJ MGP_FVBNJ_G0017720
 protein coding gene Chr10:125317794-125327044 (-)
LP/J MGP_LPJ_G0017799
 protein coding gene Chr10:133257400-133266809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017748
 protein coding gene Chr10:145307775-145318229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018321
 protein coding gene Chr10:131162171-131171559 (-)
PWK/PhJ MGP_PWKPhJ_G0016995
 protein coding gene Chr10:126663596-126673412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016784
 protein coding gene Chr10:130263908-130280519 (-)
WSB/EiJ MGP_WSBEiJ_G0017269
 protein coding gene Chr10:131394358-131405068 (-)



Homology
more
  • Human Ortholog
    GDF11, growth differentiation factor 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF11, growth differentiation factor 11
  • Synonyms
    BMP11, BMP-11, VHO
  • Links
    NCBI Gene ID: 10220
    neXtProt AC: NX_O95390
    UniProt: O95390

  • Chr Location
    12q13.2; chr12:55743122-55757264 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GDF11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 6 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die neonatally showing altered patterning of the axial skeleton including abnormal trunk-to-tail transition and ectopic ventral mass with impaired renal, palate, stomach, spleen and pancreatic development. A second null allele alters retinal and olfactory epithelium neurogenesis. A third null allele causes extra thoracic vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    126
  • cDNA Data
    8
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025352 Ensembl Gene Model | MGI Sequence Detail 9424 C57BL/6J ±  kb
    transcript ENSMUST00000026408 Ensembl | MGI Sequence Detail 4062 Not Applicable  
    polypeptide ENSMUSP00000026408 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 8
      Primer pair 6
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 41
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:53507 Nakashima M, et al., Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Mech Dev. 1999 Feb;80(2):185-9
    • Latest
      J:342958 Wang DX, et al., GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21. Nat Commun. 2023 Nov 17;14(1):7476
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory