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Dnase2a Gene Detail
Summary
  • Symbol
    Dnase2a
  • Name
    deoxyribonuclease II alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329019
    NCBI Gene: 13423
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85635384-85638332 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329019
 protein coding gene Chr8:85635189-85649544 (+)
129S1/SvImJ ENSMUSG00200024168
 protein coding gene Chr8:80000292-80003441 (+)
A/J ENSMUSG00195014616
 protein coding gene Chr8:80358484-80361632 (+)
AKR/J ENSMUSG00220021967
 protein coding gene Chr8:80399872-80403021 (+)
BALB/cJ ENSMUSG00180019428
 protein coding gene Chr8:80198983-80202132 (+)
C3H/HeJ ENSMUSG00175010815
 protein coding gene Chr8:80294168-80297316 (+)
C57BL/6NJ ENSMUSG00215009127
 protein coding gene Chr8:79931482-79934630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031316
 protein coding gene Chr8:76247950-76253845 (+)
CAST/EiJ ENSTCUG00005033927
 protein coding gene Chr8:79808629-79811781 (+)
CBA/J ENSMUSG00210020079
 protein coding gene Chr8:80281299-80284447 (+)
DBA/2J ENSMUSG00185036830
 protein coding gene Chr8:86389903-86393051 (+)
FVB/NJ ENSMUSG00205023095
 protein coding gene Chr8:79337119-79340267 (+)
JF1/MsJ ENSUMUG00000016316
 protein coding gene Chr8:88698022-88701170 (+)
LP/J ENSMUSG00230028976
 protein coding gene Chr8:89997289-90000438 (+)
NOD/ShiLtJ ENSMUSG00190026895
 protein coding gene Chr8:80357643-80360791 (+)
NZO/HlLtJ ENSMUSG00225039067
 protein coding gene Chr8:93392199-93395347 (+)
PWK/PhJ ENSLUMG00010027731
 protein coding gene Chr8:80035490-80038640 (+)
SPRET/EiJ ENSMSPG00010024624
 protein coding gene Chr8:81948571-81951819 (+)
WSB/EiJ ENSIUOG00005015713
 protein coding gene Chr8:81095225-81098374 (+)



Homology
more
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNASE2, deoxyribonuclease 2, lysosomal
  • Synonyms
    AIPCS, DNASE2A, DNL, DNL2
  • Links
    NCBI Gene ID: 1777
    UniProt: O00115

  • Chr Location
    19p13.13; chr19:12875209-12881595 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnase2a mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations of this gene result in perinatal death, anemia, and impaired definitive erythropoiesis in the fetal liver. Homozygotes for one null mutation display diaphragm abnormalities and asphyxiation, as well as a specific defect in the phagocytic phase of apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    6
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13423 NCBI Gene Model | MGI Sequence Detail 2949 C57BL/6J ±  kb
    transcript NM_001368296 RefSeq | MGI Sequence Detail 1758 ZRU/MplStud  
    polypeptide P56542 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 14
      Phenotypes 66
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:361342 Li LJ, et al., Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration. Transl Neurodegener. 2024 Aug 2;13(1):39
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory