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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dnase2a
deoxyribonuclease II alpha
MGI:1329019
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Aim2tm1.2Arte/\Aim2tm1.2Arte
\Dnase2atm1Osa/\Dnase2atm1Osa
\Ifnar1tm1Agt/\Ifnar1tm1Agt
involves: 129 * BALB/c * C57BL/6 * C57BL/6J 		abnormal spleen morphology J:238323
enlarged spleen J:238323
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating tumor necrosis factor level J:238323
increased spleen weight J:238323
rheumatoid arthritis J:238323
\Dffbtm1Osa/\Dffbtm1Osa
\Dnase2atm1Osa/\Dnase2atm1Osa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal T cell differentiation J:81474
abnormal thymus morphology J:81474
anemia J:81474
decreased body size J:81474
decreased double-positive T cell number J:81474
increased double-negative T cell number J:81474
small thymus J:81474
thymus hypoplasia J:81474
\Dnase2atm1Osa/\Dnase2atm1Osa
\Ifnar1tm1Agt/\Ifnar1tm1Agt
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal blood homeostasis J:114982
abnormal cytokine level J:114982
abnormal macrophage morphology J:114982
abnormal spleen morphology J:238323
anemia J:114982
enlarged spleen J:114982, J:238323
increased anti-double stranded DNA antibody level J:114982
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating interleukin-18 level J:114982
increased circulating tumor necrosis factor level J:114982, J:238323
increased spleen red pulp amount J:114982
increased spleen weight J:238323
joint inflammation J:114982, J:238323
postnatal growth retardation J:114982
rheumatoid arthritis J:114982, J:238323
\Dnase2atm1Osa/\Dnase2atm1Osa
\Ifnar1tm1Agt/\Ifnar1tm1Agt
\Xkr8tm1.2Osa/\Xkr8tm1.2Osa
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal Sertoli cell phagocytosis J:293092
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory