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Targeted Allele Detail
Symbol: Dnase2atm1Osa
Name: deoxyribonuclease II alpha; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:2449811
Synonyms: Dnase II-
Gene: Dnase2a  Location: Chr8:85635384-85638332 bp, + strand  Genetic Position: Chr8, 41.31 cM
Alliance: Dnase2atm1Osa page
Germline Transmission:  Earliest citation of germline transmission: J:69831
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-5 and part of exon 6 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of fetal liver RNA from E14.5 homozygous mutant embryos. No enzyme activity could be detected in homozygous mutant fetal liver extracts. (J:69831)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnase2a Mutation:  86 strains or lines available
Original:  J:69831 Kawane K, et al., Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science. 2001 May 25;292(5521):1546-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory