About   Help   FAQ
Slit2 Gene Detail
Summary
  • Symbol
    Slit2
  • Name
    slit guidance ligand 2
  • Synonyms
    b2b1200.1Clo, Drad-1, E030015M03Rik, E130320P19Rik, Slil3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315205
    NCBI Gene: 20563
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:48140480-48465075 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 26.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8883 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315205
 protein coding gene Chr5:48138633-48465077 (+)
129S1/SvImJ ENSMUSG00200000985
 protein coding gene Chr5:43661817-43986437 (+)
A/J ENSMUSG00195014896
 protein coding gene Chr5:43067577-43402372 (+)
AKR/J ENSMUSG00220000601
 protein coding gene Chr5:43125601-43460413 (+)
BALB/cJ ENSMUSG00180006386
 protein coding gene Chr5:42867740-43202539 (+)
C3H/HeJ ENSMUSG00175014910
 protein coding gene Chr5:44881225-45215990 (+)
C57BL/6NJ ENSMUSG00215001791
 protein coding gene Chr5:43604789-43929423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027208
 protein coding gene Chr5:42111146-42437878 (+)
CAST/EiJ ENSTCUG00005003076
 protein coding gene Chr5:43003075-43336810 (+)
CBA/J ENSMUSG00210024255
 protein coding gene Chr5:43816723-44151486 (+)
DBA/2J ENSMUSG00185001443
 protein coding gene Chr5:45695094-46029874 (+)
FVB/NJ ENSMUSG00205002874
 protein coding gene Chr5:42643783-42980448 (+)
JF1/MsJ ENSUMUG00000001227
 protein coding gene Chr5:50305625-50636256 (+)
LP/J ENSMUSG00230009786
 protein coding gene Chr5:50346345-50670942 (+)
NOD/ShiLtJ ENSMUSG00190000631
 protein coding gene Chr5:42761919-43100740 (+)
NZO/HlLtJ ENSMUSG00225028333
 protein coding gene Chr5:55512002-55842519 (+)
PWK/PhJ ENSLUMG00010001417
 protein coding gene Chr5:42937319-43262891 (+)
SPRET/EiJ ENSMSPG00010012186
 protein coding gene Chr5:44275563-44616121 (+)
WSB/EiJ ENSIUOG00005018753
 protein coding gene Chr5:45758945-46083859 (+)



Homology
more
  • Human Ortholog
    SLIT2, slit guidance ligand 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLIT2, slit guidance ligand 2
  • Synonyms
    SLIL3, Slit-2
  • Links
    NCBI Gene ID: 9353
    UniProt: O94813

  • Chr Location
    4p15.31; chr4:20251903-20620561 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Slit2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    23 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    155
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1267
  • Tissues
    465
  • cDNA Data
    103
  • Literature Summary
    171
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031558 Ensembl Gene Model | MGI Sequence Detail 324596 C57BL/6J ±  kb
    transcript ENSMUST00000174421 Ensembl | MGI Sequence Detail 7785 Not Applicable  
    polypeptide ENSMUSP00000134263 Ensembl | MGI Sequence Detail 1542 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000015235 slit homolog 2 protein
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR006207 Cystine knot, C-terminal
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR003645 Follistatin-like, N-terminal
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
      IPR051355 Notch and Slit guidance protein
    • GlyGen
      Q9R1B9 12 sites, 4 N-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 109
      Primer pair 10
      Other 18
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1333781, MGI:2442301, MGI:2443562, MGI:5437089
    References
    more
    • Summaries
      All 296
      Developmental Gene Expression 171
      Diseases 2
      Gene Ontology 26
      Phenotypes 102
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:377138 Wong D, et al., Slit2-robo signaling regulates angiogenesis and repair following myocardial infarction. J Mol Cell Cardiol. 2026 Jan;210:28-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory