Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables chemorepellent activity. Involved in aortic valve morphogenesis; pulmonary valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including mammary duct terminal end bud growth; negative regulation of axon extension; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Kartagener syndrome; cystic kidney disease; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human SLIT2 (slit guidance ligand 2).