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Chemically induced Allele Detail
Symbol: Slit2b2b1200.1Clo
Name: slit guidance ligand 2; Bench to Bassinet Program (B2B/CVDC) mutation 1200, subline 1, Cecilia Lo
MGI ID: MGI:5437102
Gene: Slit2  Location: Chr5:48140480-48465075 bp, + strand  Genetic Position: Chr5, 26.05 cM
Alliance: Slit2b2b1200.1Clo page
Mutant 1200-003-NA shows dextroversion {S,D,S} with vascular ring

Show the 23 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1200Clo. The molecular lesion is a T to T substitution at nucleotide +6 after coding nucleotide 1808 (c.1808+6T>T, NM_178804) in intron 17, a presumed splicing mutation. (J:175213)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slit2 Mutation:  59 strains or lines available
This mutation was derived from the parent line b2b1200Clo.

Summative Diagnosis:
Mutant Type 1:
Cardiovascular defects: Heterotaxy with congenital heart disease such as dextroversion with hypoplastic right ventricle (RV), double outlet right ventricle (DORV), muscular and membranous ventricular septal defects, aortic arch anomalies including vascular ring
Non-cardiovascular defects: Duplex kidneys with cysts and hydronephrosis

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0190 Heterotaxy Syndrome
0600 Double outlet right ventricle
1310 Ventricular septal defect, membranous
1320 Ventricular septal defect, muscular
1821 Hypoplastic right ventricle (subnormal cavity volume)
2704 Aortic arch hypoplasia
2760 Vascular ring
3804 Congenital heart disease
3953 {S,D,S}
4502 Hydronephrosis
4508 Polycystic kidney disease

Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory