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Creb1 Gene Detail
Summary
  • Symbol
    Creb1
  • Name
    cAMP responsive element binding protein 1
  • Synonyms
    2310001E10Rik, 3526402H21Rik, Creb, Creb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88494
    NCBI Gene: 12912
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:64571963-64643707 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.74 cM, cytoband C1/C5
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1609 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88494
 protein coding gene Chr1:64571804-64643707 (+)
129S1/SvImJ ENSMUSG00200003788
 protein coding gene Chr1:62064834-62136446 (+)
A/J ENSMUSG00195029794
 protein coding gene Chr1:61592693-61664306 (+)
AKR/J ENSMUSG00220034125
 protein coding gene Chr1:61710810-61789366 (+)
BALB/cJ ENSMUSG00180030212
 protein coding gene Chr1:61900069-61971979 (+)
C3H/HeJ ENSMUSG00175000796
 protein coding gene Chr1:61980966-62052583 (+)
C57BL/6NJ ENSMUSG00215021142
 protein coding gene Chr1:61925840-61997744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014207
 protein coding gene Chr1:58483238-58555302 (+)
CAST/EiJ ENSTCUG00005020673
 protein coding gene Chr1:61729410-61800400 (+)
CBA/J ENSMUSG00210003076
 protein coding gene Chr1:61666153-61737756 (+)
DBA/2J ENSMUSG00185004791
 protein coding gene Chr1:62783089-62854703 (+)
FVB/NJ ENSMUSG00205011083
 protein coding gene Chr1:61611951-61683565 (+)
JF1/MsJ ENSUMUG00000003580
 protein coding gene Chr1:61727962-61799756 (+)
LP/J ENSMUSG00230002121
 protein coding gene Chr1:62773982-62845596 (+)
NOD/ShiLtJ ENSMUSG00190012541
 protein coding gene Chr1:61843983-61915597 (+)
NZO/HlLtJ ENSMUSG00225001257
 protein coding gene Chr1:65998683-66070295 (+)
PWK/PhJ ENSLUMG00010007438
 protein coding gene Chr1:61263264-61335126 (+)
SPRET/EiJ ENSMSPG00010016971
 protein coding gene Chr1:63228734-63301633 (+)
WSB/EiJ ENSIUOG00005028121
 protein coding gene Chr1:61459196-61530731 (+)



Homology
more
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
  • Synonyms
    CREB, CREB-1
  • Links
    NCBI Gene ID: 1385
    UniProt: P16220

  • Chr Location
    2q33.3; chr2:207529737-207605988 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CREB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 7 alleles in 6 genetic backgrounds
    30 phenotypes from multigenic genotypes
    3 images
    125 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    188
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    81
  • cDNA Data
    168
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12912 NCBI Gene Model | MGI Sequence Detail 71745 C57BL/6J ±  kb
    transcript NM_009952 RefSeq | MGI Sequence Detail 8431 ZRU/MplStud  
    polypeptide Q01147 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000005854 cyclic AMP-responsive element-binding protein 1
      (term hierarchy)
    • PDB
      1DH3
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR001630 cAMP response element binding (CREB) protein
      IPR003102 Cyclic AMP-responsive element-binding protein 1-like, pKID
    • GlyGen
      Q01147 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 193
      Genomic 13
      cDNA 173
      Primer pair 6
      Other 1
      Antibodies 22

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519
    References
    more
    • Summaries
      All 666
      Developmental Gene Expression 82
      Gene Ontology 44
      Phenotypes 125
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:387963 Liao J, et al., Nf2 orchestrates beta-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2524671123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory