Gene Expression Literature Summary

• Symbol: Creb1
• Name: cAMP responsive element binding protein 1
• ID: MGI:88494

76 matching records from 76 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2.5	E3.5	E4	E6	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)	1	1	1	1	1	1	1		1	1	1	3	1	1		7	3	7	3	1	2	4	1	5		1		14
In situ RNA (section)												1		1		2	1	1	1			1		1				2
Immunohistochemistry (whole mount)							1	1		1		1				1											1
In situ RNA (whole mount)										1		1		1					1
In situ reporter (knock in)				1				1
Northern blot									3	3	3	2			1
Western blot		1								1						2	5	4	2		4			3	1			15
RT-PCR	1	1	1		1			1				1				3	1	1	1			1						5
cDNA clones												1										1
RNase protection																1		1			1	1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Creb1  cAMP responsive element binding protein 1   (Synonyms: 2310001E10Rik, 3526402H21Rik, Creb, Creb-1)
Results	Reference
1	J:284694 Akaneya Y, Sohya K, Kitamura A, Kimura F, Washburn C, Zhou R, Ninan I, Tsumoto T, Ziff EB, Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development. PLoS One. 2010 Aug 31;5(8):e12486
1	J:251794 Antony N, McDougall AR, Mantamadiotis T, Cole TJ, Bird AD, Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms. Sci Rep. 2016 May 6;6:25569
1	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
2	J:309666 Balta EA, Schaffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Haberle BM, Ueffing M, Lie DC, Gloeckner CJ, Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep. 2018 Nov 1;8(1):16196
2	J:266341 Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC, Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci. 2018;11:211
2*	J:171712 Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, Hooper SB, Cole TJ, cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
1	J:96910 Blaess S, Graus-Porta D, Belvindrah R, Radakovits R, Pons S, Littlewood-Evans A, Senften M, Guo H, Li Y, Miner JH, Reichardt LF, Muller U, Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci. 2004 Mar 31;24(13):3402-12
6	J:74982 Bleckmann SC, Blendy JA, Rudolph D, Monaghan AP, Schmid W, Schutz G, Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol. 2002 Mar;22(6):1919-25
2	J:230425 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigere F, Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5:e11627
2	J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600
2	J:105245 Chen AE, Ginty DD, Fan CM, Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2005 Jan 20;433(7023):317-22
1	J:239523 Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R, Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628
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2	J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448
1	J:222247 Duan X, Murata Y, Liu Y, Nicolae C, Olsen BR, Berendsen AD, Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development. Development. 2015 Jun 1;142(11):1984-91
1	J:140104 Franco CA, Mericskay M, Parlakian A, Gary-Bobo G, Gao-Li J, Paulin D, Gustafsson E, Li Z, Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell. 2008 Sep;15(3):448-61
1*	J:241343 Furuya S, Yoshida K, Kawakami Y, Yang JH, Sayano T, Azuma N, Tanaka H, Kuhara S, Hirabayashi Y, Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct Integr Genomics. 2008 Aug;8(3):235-49
2	J:255613 Grade CVC, Mantovani CS, Fontoura MA, Yusuf F, Brand-Saberi B, Alvares LE, CREB, NF-Y and MEIS1 conserved binding sites are essential to balance Myostatin promoter/enhancer activity during early myogenesis. Mol Biol Rep. 2017 Oct;44(5):419-427
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:139866 Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH, Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007 Oct 11;1(4):443-57
1	J:100886 Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S, A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
1	J:276614 Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S, Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia. Curr Biol. 2019 Mar 4;29(5):790-802.e5
10	J:126081 Jin XL, O'Neill C, cAMP-responsive element-binding protein expression and regulation in the mouse preimplantation embryo. Reproduction. 2007 Nov;134(5):667-75
1	J:156643 Jin XL, O'Neill C, The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo. Biol Reprod. 2010 Feb;82(2):459-68
1	J:182862 Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB, Toribio RE, La Perle KM, Kirschner LS, Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification. Mol Endocrinol. 2010 Aug;24(8):1559-68
1	J:256001 Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
1	J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748
1	J:267148 Kechele DO, Dunworth WP, Trincot CE, Wetzel-Strong SE, Li M, Ma H, Liu J, Caron KM, Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy. Hypertension. 2016 Sep;68(3):667-77
1	J:113403 Kim JW, Lemke G, Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 2006 Oct 15;20(20):2833-47
1	J:336092 Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM, Vogt D, Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs. Development. 2023 May 15;150(10):dev201371
1	J:173779 Kossler N, Stricker S, Rodelsperger C, Robinson PN, Kim J, Dietrich C, Osswald M, Kuhnisch J, Stevenson DA, Braun T, Mundlos S, Kolanczyk M, Neurofibromin (Nf1) is required for skeletal muscle development. Hum Mol Genet. 2011 Jul 15;20(14):2697-709
5*	J:272498 Landeira BS, Santana TTDS, Araujo JAM, Tabet EI, Tannous BA, Schroeder T, Costa MR, Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cereb Cortex. 2018 Feb 1;28(2):538-548
2	J:111714 Lang B, Song B, Davidson W, MacKenzie A, Smith N, McCaig CD, Harmar AJ, Shen S, Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice. J Clin Invest. 2006 Jul;116(7):1924-34
1	J:254756 Lei R, Zhang K, Wei Y, Chen M, Weinstein LS, Hong Y, Zhu M, Li H, Li H, G-Protein alpha-Subunit Gsalpha Is Required for Craniofacial Morphogenesis. PLoS One. 2016;11(2):e0147535
1*	J:268425 Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O, Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601
1	J:294283 Liang Q, Zheng Q, Zuo Y, Chen Y, Ma J, Ni P, Cheng J, SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Rep. 2019 Aug 20;28(8):2004-2011.e4
1*	J:67153 Long F, Schipani E, Asahara H, Kronenberg H, Montminy M, The CREB family of activators is required for endochondral bone development. Development. 2001 Feb;128(4):541-50
8*	J:76363 Lonze BE, Riccio A, Cohen S, Ginty DD, Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002 Apr 25;34(3):371-85
7	J:197427 Lopez TP, Fan CM, Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2019-27
4	J:104066 Mantamadiotis T, Kretz O, Ridder S, Bleckmann SC, Bock D, Grone HJ, Malaterre J, Dworkin S, Ramsay RG, Schutz G, Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol Endocrinol. 2006 Jan;20(1):204-11
2	J:76211 Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schutz G, Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54
1	J:269227 Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calmejane MA, Boeva V, Tauveron I, Lefrancois-Martinez AM, Martinez A, Val P, Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274
1*	J:160811 McDowell KA, Hutchinson AN, Wong-Goodrich SJ, Presby MM, Su D, Rodriguiz RM, Law KC, Williams CL, Wetsel WC, West AE, Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010 Jun 2;30(22):7453-65
1*	J:150128 Miro X, Zhou X, Boretius S, Michaelis T, Kubisch C, Alvarez-Bolado G, Gruss P, Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube. Dis Model Mech. 2009 Jul-Aug;2(7-8):412-8
1	J:269440 Morgan-Smith M, Wu Y, Zhu X, Pringle J, Snider WD, GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation. Elife. 2014 Jul 29;3:e02663
2	J:21291 Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH, Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model. Reprod Toxicol. 1994 Sep-Oct;8(5):383-95
2	J:286893 Ogata K, Tsumuraya T, Oka K, Shin M, Okamoto F, Kajiya H, Katagiri C, Ozaki M, Matsushita M, Okabe K, The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis. Sci Rep. 2017 Dec 22;7(1):18099
3	J:237942 Ohta S, Wang B, Mansour SL, Schoenwolf GC, SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling. Dev Biol. 2016 Dec 01;420(1):100-109
2	J:121244 Parlato R, Otto C, Begus Y, Stotz S, Schutz G, Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development. 2007 May;134(9):1663-70
1*	J:150963 Pavlinkova G, Salbaum JM, Kappen C, Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics. 2009;10:274
3	J:257473 Puri P, Schaefer CM, Bushnell D, Taglienti ME, Kreidberg JA, Yoder BK, Bates CM, Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018 Jan;188(1):84-94
1	J:171312 Sammeta N, Hardin DL, McClintock TS, Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium. Mol Cell Neurosci. 2010 Dec;45(4):398-407
1	J:308868 Senf K, Karius J, Stumm R, Neuhaus EM, Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium. Stem Cells. 2021 May;39(5):617-635
1	J:154601 Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V, Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci. 2009 Nov;12(11):1373-80
7	J:109567 Shen WB, Plachez C, Mongi AS, Richards LJ, Identification of candidate genes at the corticoseptal boundary during development. Gene Expr Patterns. 2006 Jun;6(5):471-81
1	J:278701 Shi X, Zirbes KM, Rasmussen TL, Ferdous A, Garry MG, Koyano-Nakagawa N, Garry DJ, The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem. 2015 Apr 10;290(15):9614-25
1	J:76484 Sordella R, Classon M, Hu KQ, Matheson SF, Brouns MR, Fine B, Le Zhang, Takami H, Yamada Y, Settleman J, Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development. Dev Cell. 2002 May;2(5):553-65
2*	J:215363 Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Muller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J, Holter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gomez-Skarmeta JL, Winkelmann J, Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 2014 Apr;24(4):592-603
3	J:28346 Taylor LE, Bennett GD, Finnell RH, Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar;15(1):13-25
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:74131 Umesh H, Ganesh B, Reddy CS, Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate. J Craniofac Genet Dev Biol. 2000 Oct-Dec;20(4):173-82
2	J:345099 Wang X, Zhang Y, Yu J, Ma Y, Xu Y, Shi J, Qi Z, Liu X, Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
9*	J:27449 Weston WM, Greene RM, Developmental changes in phosphorylation of the transcription factor CREB in the embryonic murine palate. J Cell Physiol. 1995 Aug;164(2):277-85
2	J:40102 Wlodarczyk BC, Craig JC, Bennett GD, Calvin JA, Finnell RH, Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology. 1996 Dec;54(6):284-97
4	J:33847 Wlodraczyk B, Bennett GD, Calvin JA, Craig JC, Finnell RH, Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development. Dev Genet. 1996;18(4):306-15
1	J:212272 Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W, Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
3	J:310896 Xia W, Liu Y, Jiao J, GRM7 regulates embryonic neurogenesis via CREB and YAP. Stem Cell Reports. 2015 May 12;4(5):795-810
1	J:128361 Xiao PJ, Hu L, Li J, Lin W, Chen X, Xu P, NSSR1 is regulated in testes development and cryptorchidism and promotes the exon 5-included splicing of CREB transcripts. Mol Reprod Dev. 2007 Nov;74(11):1363-72
1	J:323100 Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X, Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 Apr 11;57(7):839-853.e6
1	J:320691 Yadav VK, Berger JM, Singh P, Nagarajan P, Karsenty G, Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Invest. 2022 Feb 15;132(4):e153752
1*	J:227697 Yang H, Hou H, Pahng A, Gu H, Nairn AC, Tang YP, Colombo PJ, Xia H, Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor. J Neurosci. 2015 Nov 11;35(45):15082-7
1	J:310855 Yiu JHC, Cheung SWM, Cai J, Chan KS, Chen J, Cheong LY, Chau HT, Xu A, Li RHW, Woo CW, TLR5 Supports Development of Placental Labyrinthine Zone in Mice. Front Cell Dev Biol. 2021;9:711253
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2	J:330192 Zhao F, He J, Tang J, Cui N, Shi Y, Li Z, Liu S, Wang Y, Ma M, Zhao C, Luo L, Li L, Brain milieu induces early microglial maturation through the BAX-Notch axis. Nat Commun. 2022 Oct 17;13(1):6117
1	J:228307 Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B, Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71
1	J:106348 Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L, p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69