Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; protein stabilization; and regulation of lipid biosynthetic process. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; lung development; and nervous system development. Part of ATF4-CREB1 transcription factor complex and chromatin. Is active in nucleus. Is expressed in several structures, including brain; genitourinary system; limb; lung; and maxillary process. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1).