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Fryl Gene Detail
Summary
  • Symbol
    Fryl
  • Name
    FRY like transcription coactivator
  • Synonyms
    2310004H21Rik, 2510002A14Rik, 9030227G01Rik, mKIAA0826
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919563
    NCBI Gene: 72313
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73177534-73414042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6931 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919563
 protein coding gene Chr5:73177330-73414042 (-)
129S1/SvImJ ENSMUSG00200034918
 protein coding gene Chr5:68834637-69006308 (-)
A/J ENSMUSG00195031566
 protein coding gene Chr5:68158861-68330548 (-)
AKR/J ENSMUSG00220003667
 protein coding gene Chr5:68270485-68442168 (-)
BALB/cJ ENSMUSG00180021733
 protein coding gene Chr5:67915858-68087584 (-)
C3H/HeJ ENSMUSG00175026731
 protein coding gene Chr5:69984483-70156568 (-)
C57BL/6NJ ENSMUSG00215004821
 protein coding gene Chr5:68750050-68921988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027293
 protein coding gene Chr5:65968315-66201952 (-)
CAST/EiJ ENSTCUG00005030181
 protein coding gene Chr5:67726213-67895206 (-)
CBA/J ENSMUSG00210022723
 protein coding gene Chr5:68922645-69094693 (-)
DBA/2J ENSMUSG00185015955
 protein coding gene Chr5:70752299-70924453 (-)
FVB/NJ ENSMUSGG00205054482
 protein coding gene Chr5:67762732-67853093 (-)
JF1/MsJ ENSUMUG00000002994
 protein coding gene Chr5:75228917-75399336 (-)
LP/J ENSMUSG00230016940
 protein coding gene Chr5:75408982-75580653 (-)
NOD/ShiLtJ ENSMUSG00190004028
 protein coding gene Chr5:67851185-68023300 (-)
NZO/HlLtJ ENSMUSG00225008522
 protein coding gene Chr5:80479128-80650796 (-)
PWK/PhJ ENSLUMG00010012064
 protein coding gene Chr5:67807489-67977785 (-)
SPRET/EiJ ENSMSPG00010030125
 protein coding gene Chr5:69817905-69961081 (-)
WSB/EiJ ENSIUOG00005016923
 protein coding gene Chr5:70697551-70868377 (-)



Homology
more
  • Human Ortholog
    FRYL, FRY like transcription coactivator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRYL, FRY like transcription coactivator
  • Synonyms
    AF4p12, KIAA0826, MOR2, PCBS
  • Links
    NCBI Gene ID: 285527
    UniProt: O94915

  • Chr Location
    4p11; chr4:48497357-48780322 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FRYL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    412 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele exhibit postnatal lethality and defects in kidney development; rare survivors display growth retardation, decreased body weight, and premature death associated with chronic hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    637
  • Tissues
    11
  • cDNA Data
    144
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72313 NCBI Gene Model | MGI Sequence Detail 236509 C57BL/6J ±  kb
    transcript NM_028194 RefSeq | MGI Sequence Detail 11488 C57BL/6  
    polypeptide NP_082470 RefSeq | MGI Sequence Detail 3007 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR029473 Cell morphogenesis central region
      IPR025481 Cell morphogenesis protein C-terminal
      IPR025614 Cell morphogenesis protein N-terminal
      IPR045842 Protein furry, C-terminal
      IPR039867 Protein furry/Tao3/Mor2
    • GlyGen
      F8VQ05 6 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 145

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914271, MGI:1922825, MGI:2141007, MGI:2443838
    References
    more
    • Summaries
      All 440
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 412
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:390040 Dang L, et al., Activation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice. Shock. 2026 Jan 1;65(1):85-92
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory