Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Zic2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ZIC2
- Mouse genes Zic2
- Rat genes Zic2
- Zfish genes zic2a,zic2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zic2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Zic2	IDA		Mouse	MGI:MGI:4833763\|PMID:20676059
Molecular Function	GO:0003677	DNA binding	Zic2	IDA		Mouse	MGI:MGI:3771485\|PMID:18068128
Molecular Function	GO:0003677	DNA binding	Zic2	IDA		Mouse	PMID:15465018
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Zic2	IDA		Mouse	MGI:MGI:4942260\|PMID:11053430
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic2	IDA		Mouse	MGI:MGI:4942260\|PMID:11053430
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic2	IDA		Mouse	MGI:MGI:3056015\|PMID:15465018
Molecular Function	GO:0005515	protein binding	Zic2	IPI	UniProtKB:O70133	Mouse	MGI:MGI:3771485\|PMID:18068128
Molecular Function	GO:0005515	protein binding	Zic2	IPI	UniProtKB:P10071	Mouse	MGI:MGI:3688043\|PMID:11238441
Molecular Function	GO:0005515	protein binding	Zic2	IPI	UniProtKB:Q8BX65	Mouse	MGI:MGI:4943413\|PMID:15207726
Molecular Function	GO:0005515	protein binding	Zic2	IPI	UniProtKB:Q8BX65	Mouse	MGI:MGI:3056015\|PMID:15465018
Molecular Function	GO:0005515	protein binding	Zic2	IPI	UniProtKB:Q0VGT2	Mouse	PMID:21211521
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Zic2	IDA		Mouse	MGI:MGI:4942260\|PMID:11053430
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Zic2	IDA		Mouse	PMID:18298960
Cellular Component	GO:0005737	cytoplasm	Zic2	IDA		Mouse	MGI:MGI:4943413\|PMID:15207726
Cellular Component	GO:0005737	cytoplasm	Zic2	IDA		Mouse	MGI:MGI:3056015\|PMID:15465018
Cellular Component	GO:0005737	cytoplasm	Zic2	IDA		Mouse	PMID:18755297
Cellular Component	GO:0016604	nuclear body	ZIC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ZIC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	MGI:MGI:4943413\|PMID:15207726
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	MGI:MGI:3688043\|PMID:11238441
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	MGI:MGI:3771485\|PMID:18068128
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	PMID:18755297
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	PMID:12799086
Cellular Component	GO:0005634	nucleus	Zic2	IDA		Mouse	PMID:15465018
Biological Process	GO:0048318	axial mesoderm development	Zic2	IGI	MGI:MGI:106676	Mouse	PMID:17490632
Biological Process	GO:0008283	cell population proliferation	zic2b	IMP	ZFIN:ZDB-MRPHLNO-180830-11,ZFIN:ZDB-MRPHLNO-180830-10	Zfish	PMID:29719254
Biological Process	GO:0021846	cell proliferation in forebrain	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:18358464
Biological Process	GO:0033278	cell proliferation in midbrain	zic2b	IMP		Zfish	PMID:17215296
Biological Process	GO:0033278	cell proliferation in midbrain	zic2b	IGI	ZFIN:ZDB-GENE-040622-1	Zfish	PMID:17215296
Biological Process	GO:0033278	cell proliferation in midbrain	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:17215296
Biological Process	GO:0007417	central nervous system development	Zic2	IGI	MGI:MGI:106683	Mouse	PMID:11756505
Biological Process	GO:0035283	central nervous system segmentation	Zic2	IGI	MGI:MGI:106676	Mouse	PMID:17490632
Biological Process	GO:0044782	cilium organization	Zic2	IMP	MGI:MGI:1862004	Mouse	PMID:24585447
Biological Process	GO:0048066	developmental pigmentation	Zic2	IMP	MGI:MGI:1861983	Mouse	PMID:10932191
Biological Process	GO:0021536	diencephalon development	zic2a	IGI	ZFIN:ZDB-GENO-080605-1,ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:18358464
Biological Process	GO:0021536	diencephalon development	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:18358464
Biological Process	GO:0021536	diencephalon development	zic2a	IGI	ZFIN:ZDB-GENO-070406-1,ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:18358464
Biological Process	GO:0009953	dorsal/ventral pattern formation	zic2a	IGI	ZFIN:ZDB-GENO-060811-12	Zfish	PMID:18248235
Biological Process	GO:0009953	dorsal/ventral pattern formation	zic2a	IMP		Zfish	PMID:18248235
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:17215296
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:23665173
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	zic2b	IMP	ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23665173
Biological Process	GO:0010467	gene expression	Zic2	IMP		Mouse	PMID:21211521
Biological Process	GO:0010467	gene expression	Zic2	IGI	MGI:MGI:106676	Mouse	PMID:17490632
Biological Process	GO:0030902	hindbrain development	zic2a	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23937294
Biological Process	GO:0030902	hindbrain development	zic2b	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23937294
Biological Process	GO:0030901	midbrain development	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:17215296
Biological Process	GO:0030901	midbrain development	zic2a	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:19470582
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Zic2	IDA		Mouse	MGI:MGI:4942260\|PMID:11053430
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:19855021
Biological Process	GO:0007399	nervous system development	Zic2	IMP	MGI:MGI:2156825	Mouse	PMID:10677508
Biological Process	GO:0014032	neural crest cell development	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:23665173
Biological Process	GO:0014032	neural crest cell development	zic2b	IMP	ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23665173
Biological Process	GO:0014033	neural crest cell differentiation	Zic2	IMP	MGI:MGI:1862004	Mouse	PMID:15384171
Biological Process	GO:0001840	neural plate development	Zic2	IGI	MGI:MGI:106676	Mouse	PMID:17490632
Biological Process	GO:0001843	neural tube closure	Zic2	IMP	MGI:MGI:1862004	Mouse	PMID:15384171
Biological Process	GO:0001841	neural tube formation	zic2a	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:19470582
Biological Process	GO:0048339	paraxial mesoderm development	Zic2	IGI	MGI:MGI:106676	Mouse	PMID:17490632
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Zic2	IDA		Mouse	MGI:MGI:4833763\|PMID:20676059
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic2	IDA		Mouse	MGI:MGI:3056015\|PMID:15465018
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic2	IDA		Mouse	MGI:MGI:4833763\|PMID:20676059
Biological Process	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	Zic2	IMP	MGI:MGI:1862004	Mouse	PMID:24585447
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zic2	IDA		Mouse	MGI:MGI:4942260\|PMID:11053430
Biological Process	GO:0042127	regulation of cell population proliferation	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:17215296
Biological Process	GO:0048385	regulation of retinoic acid receptor signaling pathway	zic2a	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23937294
Biological Process	GO:0048385	regulation of retinoic acid receptor signaling pathway	zic2b	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-130809-1	Zfish	PMID:23937294
Biological Process	GO:0008589	regulation of smoothened signaling pathway	zic2a	IMP	ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:19855021
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Zic2	IMP		Mouse	MGI:MGI:2675195\|PMID:13678579
Biological Process	GO:0007601	visual perception	Zic2	IMP		Mouse	MGI:MGI:2675195\|PMID:13678579
Biological Process	GO:0007601	visual perception	Zic2	IMP		Mouse	MGI:MGI:4833763\|PMID:20676059

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.