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Zic2 Gene Detail
Summary
  • Symbol
    Zic2
  • Name
    zinc finger protein of the cerebellum 2
  • Synonyms
    GENA 29, Ku, odd-paired homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:106679
    NCBI Gene: 22772
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:122712847-122717264 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106679
 protein coding gene Chr14:122712796-122717740 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021672
 protein coding gene Chr14:120390516-120394834 (+)
A/J MGP_AJ_G0021632
 protein coding gene Chr14:115714454-115718873 (+)
AKR/J MGP_AKRJ_G0021608
 protein coding gene Chr14:119457652-119462071 (+)
BALB/cJ MGP_BALBcJ_G0021638
 protein coding gene Chr14:116263284-116267703 (+)
C3H/HeJ MGP_C3HHeJ_G0021415
 protein coding gene Chr14:119350235-119354652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022078
 protein coding gene Chr14:125008208-125014864 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019616
 protein coding gene Chr14:111574710-111579107 (+)
CAST/EiJ MGP_CASTEiJ_G0020931
 protein coding gene Chr14:117267682-117272484 (+)
CBA/J MGP_CBAJ_G0021384
 protein coding gene Chr14:129767624-129772041 (+)
DBA/2J MGP_DBA2J_G0021507
 protein coding gene Chr14:115571862-115576258 (+)
FVB/NJ MGP_FVBNJ_G0021485
 protein coding gene Chr14:113926300-113933456 (+)
LP/J MGP_LPJ_G0021575
 protein coding gene Chr14:121302871-121307288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021512
 protein coding gene Chr14:134742087-134746541 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022101
 protein coding gene Chr14:119054097-119058514 (+)
PWK/PhJ MGP_PWKPhJ_G0020675
 protein coding gene Chr14:112635105-112645771 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020513
 protein coding gene Chr14:115231856-115242226 (+)
WSB/EiJ MGP_WSBEiJ_G0020987
 protein coding gene Chr14:119725603-119730018 (+)



Homology
more
  • Human Ortholog
    ZIC2, Zic family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZIC2, Zic family member 2
  • Synonyms
    HPE5
  • Links
    NCBI Gene ID: 7546
    UniProt: O95409

  • Chr Location
    13q32.3; chr13:99981784-99986765 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Zic2 mouse models; 2 with human ZIC2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 9 alleles in 10 genetic backgrounds
    7 phenotypes from multigenic genotypes
    4 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects. A critical mutation in the last zinc finger domain results in multiple isomerism-related and other malformations in the embryonic brain, eyes, heart, lungs, cardiopulmonary vasculature, and digestive organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1256
  • Tissues
    296
  • cDNA Data
    14
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061524 Ensembl Gene Model | MGI Sequence Detail 4418 C57BL/6J ±  kb
    transcript ENSMUST00000075888 Ensembl | MGI Sequence Detail 2440 Not Applicable  
    polypeptide ENSMUSP00000075283 Ensembl | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 15
      Primer pair 9
      Other 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35138, MGI:1861983
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 110
      Diseases 4
      Gene Ontology 23
      Phenotypes 38
    • Earliest
      J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
    • Latest
      J:365305 Dolique T, et al., A central role for Numb/Nbl in multiple Shh-mediated axon repulsion processes. iScience. 2025 May 16;28(5):112293
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory