Zic2
Gene Detail

Symbol

Name
ID

Zic2
zinc finger protein of the cerebellum 2
MGI:106679

Synonyms

GENA 29, Ku, odd-paired homolog

Feature Type

protein coding gene

Genetic Map

Chromosome 14
65.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:122475435-122479852 bp, + strand From VEGA annotation of GRCm38   4418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:5171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zic2

Human
homologs

Human Homolog		ZIC2, Zic family member 2
NCBI Gene ID		7546
neXtProt AC		NX_O95409
Human Synonyms		HPE5
Human Chr (Location)		13q32; chr13:99981772-99986765 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ZIC2

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Chemically induced (ENU)(2) Endonuclease-mediated(5) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.

 
Human Diseases Modeled in Mice Using Zic2 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)

Interactions

Zic2 interacts with 141 markers (Mir10b, Mir17, Mir18, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (31 annotations)

Process	cell differentiation, central nervous system development, ...
Component	cytoplasm, nucleus
Function	chromatin DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (69 records)

Data Summary: Results (316)    Tissues (222)    Images (82)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	48
RNA in situ	183
Northern blot	26
RT-PCR	59

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(24) Genomic(3) cDNA(13) Primer pair(6) Other(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000020302 (Evidence)
Ensembl Gene Model	ENSMUSG00000061524 (Evidence)
Entrez Gene	22772 (Evidence)
UniGene	308936
DFCI	TC1588391, TC1591338, TC1653500
DoTS	DT.40139868, DT.91337524, DT.91290730
NIA Mouse Gene Index	U015999
Consensus CDS Project	CCDS27349.1
International Mouse Knockout Project Status	Zic2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020302	VEGA Gene Model | MGI Sequence Detail	4418	C57BL/6J
transcript	OTTMUST00000048178	VEGA | MGI Sequence Detail	2440	Not Applicable
polypeptide	OTTMUSP00000022013	VEGA | MGI Sequence Detail	529	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs within 2kb(11 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017666	zinc finger protein ZIC 2

References

(Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:216507 Chervenak AP, et al., The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes. Dev Dyn. 2014 Nov;243(11):1487-98
All references(114)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-35138, MGI:1861983