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Zic2 Gene Detail
Summary
  • Symbol
    Zic2
  • Name
    zinc finger protein of the cerebellum 2
  • Synonyms
    GENA 29, Ku, odd-paired homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:106679
    NCBI Gene: 22772
  • Gene Overview
    MyGene.info: ZIC2
Location & Maps
more
  • Sequence Map
    Chr14:122475435-122479852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4418 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZIC2, Zic family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZIC2, Zic family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPE5
  • Links
    NCBI Gene ID: 7546
    neXtProt AC: NX_O95409

  • Chr Location
    13q32; chr13:99981772-99986765 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 5171
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ZIC2
  • Gene Tree
    Zic2
Human Diseases
more
  • Diseases
    2 with Zic2 mouse models; 1 with human ZIC2 associations

Human Disease Mouse Models
       Holoprosencephaly 5; HPE5   OMIM: 609637 View 1 model
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 8 alleles in 8 genetic backgrounds
    4 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    2
  • Endonuclease-mediated
    5
  • Gene trapped
    2
  • Targeted
    2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    317
  • Tissues
    222
  • cDNA Data
    12
  • Literature Summary
    72
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020302 VEGA Gene Model | MGI Sequence Detail 4418 C57BL/6J ±  kb
transcript OTTMUST00000048178 VEGA | MGI Sequence Detail 2440 Not Applicable  
polypeptide OTTMUSP00000022013 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    11 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017666 zinc finger protein ZIC 2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 25
    Genomic 3
    cDNA 13
    Primer pair 6
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35138, MGI:1861983
References
more
  • Summaries
    All 114
    Developmental Gene Expression 72
    Diseases 2
    Gene Ontology 18
    Phenotypes 25
  • Earliest
    J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
  • Latest
    J:231654 Sanchez-Ferras O, et al., A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network. Development. 2016 Apr 15;143(8):1363-74
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory