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Zic2
Gene Detail
Symbol

Name
ID
Zic2
zinc finger protein of the cerebellum 2
MGI:106679
Synonyms
GENA 29, Ku, odd-paired homolog
Feature Type
protein coding gene
Genetic Map
Chromosome 14
65.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:122475435-122479852 bp, + strand
From VEGA annotation of GRCm38

  4418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zic2

Human
homologs
Human Homolog ZIC2, Zic family member 2
NCBI Gene ID 7546
neXtProt AC  NX_O95409
Human Synonyms  HPE5
Human Chr (Location)  13q32; chr13:99981772-99986765 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZIC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(2) Endonuclease-mediated(5) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.
 
Human Diseases Modeled Using Mouse Zic2 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Zic2 interacts with 141 markers (Mir10b, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell differentiation, central nervous system development, ...
Component cytoplasm, nucleus
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (316)    Tissues (222)    Images (82)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 183
Northern blot 26
RT-PCR 59
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(3) cDNA(13) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020302 (Evidence)
Ensembl Gene ModelENSMUSG00000061524 (Evidence)
Entrez Gene22772 (Evidence)
UniGene308936
DFCITC1591338, TC1588391, TC1653500
DoTSDT.91337524, DT.91290730, DT.40139868
NIA Mouse Gene IndexU015999
Consensus CDS ProjectCCDS27349.1
International Mouse Knockout Project StatusZic2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020302 VEGA Gene Model | MGI Sequence Detail 4418 C57BL/6J ±  kb
transcript OTTMUST00000048178 VEGA | MGI Sequence Detail 2440 Not Applicable 
polypeptide OTTMUSP00000022013 VEGA | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017666 zinc finger protein ZIC 2
References
(Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:211641 Bhansali P, et al., Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. Neural Dev. 2014;9:11
All references(111)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35138, MGI:1861983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory