Zic2 MGI Mouse Gene Detail - MGI:106679 - zinc finger protein of the cerebellum 2

Zic2 Gene Detail

Symbol

Zic2
Name

zinc finger protein of the cerebellum 2
Synonyms

GENA 29, Ku, odd-paired homolog

Feature Type

protein coding gene
IDs

MGI:106679
NCBI Gene: 22772
Gene Overview

MyGene.info: ZIC2

Sequence Map

Chr14:122475435-122479852 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4418 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 65.97 cM
Mapping Data

2 experiments

Human Ortholog

ZIC2, Zic family member 2

Vertebrate Orthologs

10

Human Ortholog

ZIC2, Zic family member 2
Orthology source: HomoloGene, HGNC
Synonyms

HPE5
Links

HGNC:12873

NCBI Gene ID: 7546

neXtProt AC: NX_O95409

UniProt: O95409
Chr Location

13q32.3; chr13:99981772-99986765 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5171
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ZIC2
Gene Tree

Zic2

Diseases

2 with Zic2 mouse models; 1 with human ZIC2 associations

Human Disease

Mouse Models

holoprosencephaly 5

IDs

View 3 models

schizophrenia

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

4 with disease annotations

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Phenotype Summary

70 phenotypes from 8 alleles in 9 genetic backgrounds
7 phenotypes from multigenic genotypes
4 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

2
Endonuclease-mediated

5
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.

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All GO Annotations

31
GO References

18

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

317
Tissues

222
cDNA Data

12
Literature Summary

74

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zic2

ZFIN zic2a, zic2b

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Zic2 interacts with 141 markers (Mir10b, Mir17, Mir18, ...) View All

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All Sequences

24
RefSeq

2
UniProt

3
CCDS

CCDS27349.1
UniGene

308936

			Length	Strain/Species	Flank
genomic	OTTMUSG00000020302	VEGA Gene Model \| MGI Sequence Detail	4418	C57BL/6J	± kb
transcript	OTTMUST00000048178	VEGA \| MGI Sequence Detail	2440	Not Applicable
polypeptide	OTTMUSP00000022013	VEGA \| MGI Sequence Detail	529	Not Applicable

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SNPs within 2kb

11 from dbSNP Build 142

PCR

1

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UniProt

3 Sequences
Protein Ontology

PR:000017666 zinc finger protein ZIC 2

(term hierarchy)
InterPro Domains

IPR013087 Zinc finger C2H2-type

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All nucleic 25

Genomic 3

cDNA 13

Primer pair 6

Other 3

Microarray probesets 4

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MGD-MRK-35138, MGI:1861983

Summaries

All 117

Developmental Gene Expression 74

Diseases 4

Gene Ontology 18

Phenotypes 26
Earliest

J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
Latest

J:238567 Houtmeyers R, et al., Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling. Hum Mol Genet. 2016 Sep 15;25(18):3946-3959

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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