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Zic2
Gene Detail
Symbol

Name
ID
Zic2
zinc finger protein of the cerebellum 2
MGI:106679
Synonyms
GENA 29, Ku, odd-paired homolog
Feature Type
protein coding gene
Genetic Map
Chromosome 14
65.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:122475435-122479852 bp, + strand
From VEGA annotation of GRCm38

  4418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZIC2
Gene Tree: Zic2

Human
homologs
ZIC2, Zic family member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7546
neXtProt AC: NX_O95409

Human Synonyms: HPE5

Human Chr (Location): 13q32; chr13:99981772-99986765 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZIC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(2) Endonuclease-mediated(5) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants. Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.
 
Human Diseases Modeled in Mice Using Zic2 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Zic2 interacts with 141 markers (Mir10b, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell differentiation, central nervous system development, ...
Component cytoplasm, nucleus
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (316)    Tissues (222)    Images (82)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 183
Northern blot 26
RT-PCR 59
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase zic2 ; ZFIN zic2a, zic2b    NEW 
Molecular
reagents
All nucleic(24) Genomic(3) cDNA(13) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020302 (Evidence)
Ensembl Gene Model ENSMUSG00000061524 (Evidence)
Entrez Gene 22772 (Evidence)
UniGene 308936
DFCI TC1588391, TC1591338, TC1653500
DoTS DT.40139868, DT.91290730, DT.91337524
NIA Mouse Gene Index U015999
Consensus CDS Project CCDS27349.1
International Mouse Phenotyping Consortium Status Zic2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020302 VEGA Gene Model | MGI Sequence Detail 4418 C57BL/6J ±  kb
transcript OTTMUST00000048178 VEGA | MGI Sequence Detail 2440 Not Applicable 
polypeptide OTTMUSP00000022013 VEGA | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017666 zinc finger protein ZIC 2
References
(Earliest) J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
(Latest) J:217604 Lavado A, et al., The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development. 2014 Nov;141(21):4182-93
All references(113)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35138, MGI:1861983

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory