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Gene Ontology Browser
Term Detail
GO term:regulation of smoothened signaling pathway
Synonym: regulation of hedgehog signaling pathway
Synonym: regulation of hh signaling pathway
Synonym: regulation of smoothened activity
Synonym: regulation of smoothened by patched
Synonym: regulation of smoothened receptor activity by patched
Synonym: regulation of smoothened signalling pathway
GO id:GO:0008589
Definition:Any process that modulates the frequency, rate or extent of smoothened signaling.
Number of paths to term: 30

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell communication
                                                is-aregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-asmoothened signaling pathway
                                                                part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                                negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                                positively-regulatespositive regulation of smoothened signaling pathway +
                                                                regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                        is-anegative regulation of smoothened signaling pathway +
                                                                        is-apositive regulation of smoothened signaling pathway +
                                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                part-ofsignal transduction downstream of smoothened +
                                                                is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                                is-asmoothened signaling pathway involved in lung development
                                                                is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                                is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                                is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                regulatesregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of signaling
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-aregulation of cell communication
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        regulatesregulation of cell communication
                                                is-aregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-asmoothened signaling pathway
                                                                part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                                negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                                positively-regulatespositive regulation of smoothened signaling pathway +
                                                                regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                        is-anegative regulation of smoothened signaling pathway +
                                                                        is-apositive regulation of smoothened signaling pathway +
                                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                part-ofsignal transduction downstream of smoothened +
                                                                is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                                is-asmoothened signaling pathway involved in lung development
                                                                is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                                is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                                is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                regulatesregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-aregulation of cell communication
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of response to stimulus
                                is-aregulation of signal transduction
                                        is-aadaptation of signaling pathway +
                                        is-aextracellular regulation of signal transduction +
                                        is-amodulation of signal transduction in other organism +
                                        is-anegative regulation of signal transduction +
                                        is-apositive regulation of signal transduction +
                                        is-aregulation of abscisic acid-activated signaling pathway +
                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                        is-aregulation of apoptotic signaling pathway +
                                        is-aregulation of auxin mediated signaling pathway +
                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                        is-aregulation of CD40 signaling pathway +
                                        is-aregulation of cytokine-mediated signaling pathway +
                                        is-aregulation of cytokinin-activated signaling pathway +
                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                        is-aregulation of ephrin receptor signaling pathway +
                                        is-aregulation of ERBB signaling pathway +
                                        is-aregulation of Fas signaling pathway +
                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                        is-aregulation of glucose mediated signaling pathway +
                                        is-aregulation of glutamate receptor signaling pathway +
                                        is-aregulation of growth hormone receptor signaling pathway +
                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                        is-aregulation of insulin receptor signaling pathway +
                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                        is-aregulation of integrin-mediated signaling pathway +
                                        is-aregulation of intracellular signal transduction +
                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                        is-aregulation of jasmonic acid mediated signaling pathway
                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                        is-aregulation of netrin-activated signaling pathway +
                                        is-aregulation of neuronal signal transduction +
                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                        is-aregulation of Notch signaling pathway +
                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                        is-aregulation of phosphorelay signal transduction system +
                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                        is-aregulation of receptor activity +
                                        is-aregulation of red or far-red light signaling pathway +
                                        is-aregulation of retinoic acid receptor signaling pathway +
                                        is-aregulation of Roundabout signaling pathway +
                                        is-aregulation of salicylic acid mediated signaling pathway +
                                        is-aregulation of semaphorin-plexin signaling pathway +
                                        is-aregulation of sevenless signaling pathway +
                                        is-aregulation of signal transduction by receptor internalization +
                                        is-aregulation of signal transduction in response to host +
                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                is-anegative regulation of smoothened signaling pathway +
                                                is-apositive regulation of smoothened signaling pathway +
                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                        is-aregulation of sphingolipid mediated signaling pathway +
                                        is-aregulation of SREBP signaling pathway +
                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                        is-aregulation of Toll signaling pathway +
                                        is-aregulation of toll-like receptor signaling pathway +
                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                        is-aregulation of vitamin D receptor signaling pathway +
                                        is-aregulation of Wnt signaling pathway +
                                        is-asignal clustering
                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of signaling
                                is-aregulation of signal transduction
                                        is-aadaptation of signaling pathway +
                                        is-aextracellular regulation of signal transduction +
                                        is-amodulation of signal transduction in other organism +
                                        is-anegative regulation of signal transduction +
                                        is-apositive regulation of signal transduction +
                                        is-aregulation of abscisic acid-activated signaling pathway +
                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                        is-aregulation of apoptotic signaling pathway +
                                        is-aregulation of auxin mediated signaling pathway +
                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                        is-aregulation of CD40 signaling pathway +
                                        is-aregulation of cytokine-mediated signaling pathway +
                                        is-aregulation of cytokinin-activated signaling pathway +
                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                        is-aregulation of ephrin receptor signaling pathway +
                                        is-aregulation of ERBB signaling pathway +
                                        is-aregulation of Fas signaling pathway +
                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                        is-aregulation of glucose mediated signaling pathway +
                                        is-aregulation of glutamate receptor signaling pathway +
                                        is-aregulation of growth hormone receptor signaling pathway +
                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                        is-aregulation of insulin receptor signaling pathway +
                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                        is-aregulation of integrin-mediated signaling pathway +
                                        is-aregulation of intracellular signal transduction +
                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                        is-aregulation of jasmonic acid mediated signaling pathway
                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                        is-aregulation of netrin-activated signaling pathway +
                                        is-aregulation of neuronal signal transduction +
                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                        is-aregulation of Notch signaling pathway +
                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                        is-aregulation of phosphorelay signal transduction system +
                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                        is-aregulation of receptor activity +
                                        is-aregulation of red or far-red light signaling pathway +
                                        is-aregulation of retinoic acid receptor signaling pathway +
                                        is-aregulation of Roundabout signaling pathway +
                                        is-aregulation of salicylic acid mediated signaling pathway +
                                        is-aregulation of semaphorin-plexin signaling pathway +
                                        is-aregulation of sevenless signaling pathway +
                                        is-aregulation of signal transduction by receptor internalization +
                                        is-aregulation of signal transduction in response to host +
                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                is-anegative regulation of smoothened signaling pathway +
                                                is-apositive regulation of smoothened signaling pathway +
                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                        is-aregulation of sphingolipid mediated signaling pathway +
                                        is-aregulation of SREBP signaling pathway +
                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                        is-aregulation of Toll signaling pathway +
                                        is-aregulation of toll-like receptor signaling pathway +
                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                        is-aregulation of vitamin D receptor signaling pathway +
                                        is-aregulation of Wnt signaling pathway +
                                        is-asignal clustering
                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        regulatesregulation of response to stimulus
                                is-aregulation of signal transduction
                                        is-aadaptation of signaling pathway +
                                        is-aextracellular regulation of signal transduction +
                                        is-amodulation of signal transduction in other organism +
                                        is-anegative regulation of signal transduction +
                                        is-apositive regulation of signal transduction +
                                        is-aregulation of abscisic acid-activated signaling pathway +
                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                        is-aregulation of apoptotic signaling pathway +
                                        is-aregulation of auxin mediated signaling pathway +
                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                        is-aregulation of CD40 signaling pathway +
                                        is-aregulation of cytokine-mediated signaling pathway +
                                        is-aregulation of cytokinin-activated signaling pathway +
                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                        is-aregulation of ephrin receptor signaling pathway +
                                        is-aregulation of ERBB signaling pathway +
                                        is-aregulation of Fas signaling pathway +
                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                        is-aregulation of glucose mediated signaling pathway +
                                        is-aregulation of glutamate receptor signaling pathway +
                                        is-aregulation of growth hormone receptor signaling pathway +
                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                        is-aregulation of insulin receptor signaling pathway +
                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                        is-aregulation of integrin-mediated signaling pathway +
                                        is-aregulation of intracellular signal transduction +
                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                        is-aregulation of jasmonic acid mediated signaling pathway
                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                        is-aregulation of netrin-activated signaling pathway +
                                        is-aregulation of neuronal signal transduction +
                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                        is-aregulation of Notch signaling pathway +
                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                        is-aregulation of phosphorelay signal transduction system +
                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                        is-aregulation of receptor activity +
                                        is-aregulation of red or far-red light signaling pathway +
                                        is-aregulation of retinoic acid receptor signaling pathway +
                                        is-aregulation of Roundabout signaling pathway +
                                        is-aregulation of salicylic acid mediated signaling pathway +
                                        is-aregulation of semaphorin-plexin signaling pathway +
                                        is-aregulation of sevenless signaling pathway +
                                        is-aregulation of signal transduction by receptor internalization +
                                        is-aregulation of signal transduction in response to host +
                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                is-anegative regulation of smoothened signaling pathway +
                                                is-apositive regulation of smoothened signaling pathway +
                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                        is-aregulation of sphingolipid mediated signaling pathway +
                                        is-aregulation of SREBP signaling pathway +
                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                        is-aregulation of Toll signaling pathway +
                                        is-aregulation of toll-like receptor signaling pathway +
                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                        is-aregulation of vitamin D receptor signaling pathway +
                                        is-aregulation of Wnt signaling pathway +
                                        is-asignal clustering
                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                regulatesregulation of signaling
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                regulatesregulation of signaling
                                        is-aregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-asmoothened signaling pathway
                                                        part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                        negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                        positively-regulatespositive regulation of smoothened signaling pathway +
                                                        regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        part-ofsignal transduction downstream of smoothened +
                                                        is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                        is-asmoothened signaling pathway involved in lung development
                                                        is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                        is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                        is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        regulatesregulation of signal transduction
                                                is-aadaptation of signaling pathway +
                                                is-aextracellular regulation of signal transduction +
                                                is-amodulation of signal transduction in other organism +
                                                is-anegative regulation of signal transduction +
                                                is-apositive regulation of signal transduction +
                                                is-aregulation of abscisic acid-activated signaling pathway +
                                                is-aregulation of anti-Mullerian hormone signaling pathway +
                                                is-aregulation of antigen receptor-mediated signaling pathway +
                                                is-aregulation of apoptotic signaling pathway +
                                                is-aregulation of auxin mediated signaling pathway +
                                                is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                is-aregulation of brassinosteroid mediated signaling pathway +
                                                is-aregulation of CD40 signaling pathway +
                                                is-aregulation of cytokine-mediated signaling pathway +
                                                is-aregulation of cytokinin-activated signaling pathway +
                                                is-aregulation of endoplasmic reticulum unfolded protein response +
                                                is-aregulation of ephrin receptor signaling pathway +
                                                is-aregulation of ERBB signaling pathway +
                                                is-aregulation of Fas signaling pathway +
                                                is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                is-aregulation of gibberellic acid mediated signaling pathway +
                                                is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                is-aregulation of glucocorticoid mediated signaling pathway +
                                                is-aregulation of glucose mediated signaling pathway +
                                                is-aregulation of glutamate receptor signaling pathway +
                                                is-aregulation of growth hormone receptor signaling pathway +
                                                is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                is-aregulation of insulin receptor signaling pathway +
                                                is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                is-aregulation of integrin-mediated signaling pathway +
                                                is-aregulation of intracellular signal transduction +
                                                is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                is-aregulation of jasmonic acid mediated signaling pathway
                                                is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                is-aregulation of netrin-activated signaling pathway +
                                                is-aregulation of neuronal signal transduction +
                                                is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                is-aregulation of Notch signaling pathway +
                                                is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                is-aregulation of phosphorelay signal transduction system +
                                                is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                is-aregulation of receptor activity +
                                                is-aregulation of red or far-red light signaling pathway +
                                                is-aregulation of retinoic acid receptor signaling pathway +
                                                is-aregulation of Roundabout signaling pathway +
                                                is-aregulation of salicylic acid mediated signaling pathway +
                                                is-aregulation of semaphorin-plexin signaling pathway +
                                                is-aregulation of sevenless signaling pathway +
                                                is-aregulation of signal transduction by receptor internalization +
                                                is-aregulation of signal transduction in response to host +
                                                is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                        is-anegative regulation of smoothened signaling pathway +
                                                        is-apositive regulation of smoothened signaling pathway +
                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                is-aregulation of sphingolipid mediated signaling pathway +
                                                is-aregulation of SREBP signaling pathway +
                                                is-aregulation of thyroid hormone mediated signaling pathway +
                                                is-aregulation of Toll signaling pathway +
                                                is-aregulation of toll-like receptor signaling pathway +
                                                is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                is-aregulation of vascular endothelial growth factor signaling pathway +
                                                is-aregulation of vitamin D receptor signaling pathway +
                                                is-aregulation of Wnt signaling pathway +
                                                is-asignal clustering
                                                is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        regulatesregulation of cell communication
                                                is-aregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-asmoothened signaling pathway
                                                                part-ofciliary receptor clustering involved in smoothened signaling pathway
                                                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                                                negatively-regulatesnegative regulation of smoothened signaling pathway +
                                                                positively-regulatespositive regulation of smoothened signaling pathway +
                                                                regulatesregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                        is-anegative regulation of smoothened signaling pathway +
                                                                        is-apositive regulation of smoothened signaling pathway +
                                                                        is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                part-ofsignal transduction downstream of smoothened +
                                                                is-asmoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                                is-asmoothened signaling pathway involved in growth plate cartilage chondrocyte development
                                                                is-asmoothened signaling pathway involved in lung development
                                                                is-asmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                                                is-asmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                                                is-asmoothened signaling pathway involved in ventral spinal cord patterning +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                regulatesregulation of signal transduction
                                                        is-aadaptation of signaling pathway +
                                                        is-aextracellular regulation of signal transduction +
                                                        is-amodulation of signal transduction in other organism +
                                                        is-anegative regulation of signal transduction +
                                                        is-apositive regulation of signal transduction +
                                                        is-aregulation of abscisic acid-activated signaling pathway +
                                                        is-aregulation of anti-Mullerian hormone signaling pathway +
                                                        is-aregulation of antigen receptor-mediated signaling pathway +
                                                        is-aregulation of apoptotic signaling pathway +
                                                        is-aregulation of auxin mediated signaling pathway +
                                                        is-aregulation of brain-derived neurotrophic factor receptor signaling pathway +
                                                        is-aregulation of brassinosteroid mediated signaling pathway +
                                                        is-aregulation of CD40 signaling pathway +
                                                        is-aregulation of cytokine-mediated signaling pathway +
                                                        is-aregulation of cytokinin-activated signaling pathway +
                                                        is-aregulation of endoplasmic reticulum unfolded protein response +
                                                        is-aregulation of ephrin receptor signaling pathway +
                                                        is-aregulation of ERBB signaling pathway +
                                                        is-aregulation of Fas signaling pathway +
                                                        is-aregulation of Fc receptor mediated stimulatory signaling pathway +
                                                        is-aregulation of fibroblast growth factor receptor signaling pathway +
                                                        is-aregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aregulation of gibberellic acid mediated signaling pathway +
                                                        is-aregulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +
                                                        is-aregulation of glucocorticoid mediated signaling pathway +
                                                        is-aregulation of glucose mediated signaling pathway +
                                                        is-aregulation of glutamate receptor signaling pathway +
                                                        is-aregulation of growth hormone receptor signaling pathway +
                                                        is-aregulation of hepatocyte growth factor receptor signaling pathway +
                                                        is-aregulation of hypoxia-inducible factor-1alpha signaling pathway +
                                                        is-aregulation of insulin receptor signaling pathway +
                                                        is-aregulation of insulin-like growth factor receptor signaling pathway +
                                                        is-aregulation of integrin-mediated signaling pathway +
                                                        is-aregulation of intracellular signal transduction +
                                                        is-aregulation of intracellular steroid hormone receptor signaling pathway +
                                                        is-aregulation of jasmonic acid mediated signaling pathway
                                                        is-aregulation of lipopolysaccharide-mediated signaling pathway +
                                                        is-aregulation of netrin-activated signaling pathway +
                                                        is-aregulation of neuronal signal transduction +
                                                        is-aregulation of neurotrophin TRK receptor signaling pathway +
                                                        is-aregulation of Notch signaling pathway +
                                                        is-aregulation of peptidoglycan recognition protein signaling pathway +
                                                        is-aregulation of peroxisome proliferator activated receptor signaling pathway +
                                                        is-aregulation of phosphorelay signal transduction system +
                                                        is-aregulation of platelet-derived growth factor receptor signaling pathway +
                                                        is-aregulation of receptor activity +
                                                        is-aregulation of red or far-red light signaling pathway +
                                                        is-aregulation of retinoic acid receptor signaling pathway +
                                                        is-aregulation of Roundabout signaling pathway +
                                                        is-aregulation of salicylic acid mediated signaling pathway +
                                                        is-aregulation of semaphorin-plexin signaling pathway +
                                                        is-aregulation of sevenless signaling pathway +
                                                        is-aregulation of signal transduction by receptor internalization +
                                                        is-aregulation of signal transduction in response to host +
                                                        is-aregulation of signal transduction involved in conjugation with cellular fusion +
                                                        is-aregulation of smoothened signaling pathway [GO:0008589] (63 genes, 88 annotations)
                                                                is-anegative regulation of smoothened signaling pathway +
                                                                is-apositive regulation of smoothened signaling pathway +
                                                                is-aregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +
                                                        is-aregulation of sphingolipid mediated signaling pathway +
                                                        is-aregulation of SREBP signaling pathway +
                                                        is-aregulation of thyroid hormone mediated signaling pathway +
                                                        is-aregulation of Toll signaling pathway +
                                                        is-aregulation of toll-like receptor signaling pathway +
                                                        is-aregulation of transmembrane receptor protein serine/threonine kinase signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor receptor signaling pathway +
                                                        is-aregulation of vascular endothelial growth factor signaling pathway +
                                                        is-aregulation of vitamin D receptor signaling pathway +
                                                        is-aregulation of Wnt signaling pathway +
                                                        is-asignal clustering
                                                        is-asignal complex assembly


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory