Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRIM5
  • Mouse genes Trim12c
  • Rat genes Trim5
  • Zfish genes btr16,si:ch211-114c12.5,si:ch211-120g10.1,si:ch73-364h19.2,si:dkey-18p12.4,si:dkey-219e21.2,trim47,zgc:194990
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trim12c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TRIM5	IPI	UniProtKB:Q9C035	Human	PMID:22493164
Molecular Function	GO:0042802	identical protein binding	TRIM5	IPI	UniProtKB:Q9C035	Human	PMID:22829933
Molecular Function	GO:0038187	pattern recognition receptor activity	TRIM5	IDA		Human	PMID:21512573
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q13501	Human	PMID:20357094
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:O43318	Human	PMID:21512573
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q8N5C8	Human	PMID:21512573
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q9NYJ8	Human	PMID:21512573
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:P35998	Human	PMID:22078707
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q13049	Human	PMID:22493164
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:O95166	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:P60520	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q13501	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q14457|UniProtKB:Q6ZNE5|UniProtKB:Q9C0C7	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q9BXW4	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q9GZQ8	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q9H0R8	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:Q9H492	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	TRIM5	IPI	UniProtKB:O95863	Human	PMID:25203322
Molecular Function	GO:0042803	protein homodimerization activity	TRIM5	IPI	UniProtKB:Q9C035	Human	PMID:11331580
Molecular Function	GO:0019901	protein kinase binding	TRIM5	IPI	UniProtKB:O75385	Human	PMID:25127057
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TRIM5	IPI	UniProtKB:O75385|UniProtKB:Q14457	Human	PMID:25127057
Molecular Function	GO:0003713	transcription coactivator activity	TRIM5	IDA		Human	PMID:23077300
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TRIM5	IDA		Human	PMID:21512573
Cellular Component	GO:0005737	cytoplasm	TRIM5	IDA		Human	PMID:18248090
Cellular Component	GO:0005737	cytoplasm	TRIM5	IDA		Human	PMID:25127057
Cellular Component	GO:1990462	omegasome	TRIM5	IDA		Human	PMID:25127057
Cellular Component	GO:0000932	P-body	TRIM5	IDA		Human	PMID:20357094
Biological Process	GO:0002218	activation of innate immune response	TRIM5	IDA		Human	PMID:21512573
Biological Process	GO:0006914	autophagy	TRIM5	IDA		Human	PMID:25127057
Biological Process	GO:0045087	innate immune response	TRIM5	IDA		Human	PMID:18248090
Biological Process	GO:0046597	negative regulation of viral entry into host cell	TRIM5	IDA		Human	PMID:18248090
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	TRIM5	IMP		Human	PMID:23077300
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TRIM5	IMP		Human	PMID:21512573
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TRIM5	IDA		Human	PMID:23077300
Biological Process	GO:0043410	positive regulation of MAPK cascade	TRIM5	IMP		Human	PMID:21512573
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TRIM5	IMP		Human	PMID:21512573
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TRIM5	IMP		Human	PMID:23077300
Biological Process	GO:0070534	protein K63-linked ubiquitination	TRIM5	IDA		Human	PMID:21512573
Biological Process	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	TRIM5	IMP		Human	PMID:21512573
Biological Process	GO:0032880	regulation of protein localization	TRIM5	IMP		Human	PMID:25127057
Biological Process	GO:0044790	suppression of viral release by host	TRIM5	IDA		Human	PMID:18248090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern