| GO term: | protein K63-linked ubiquitination |
| Synonym: | protein K63-linked polyubiquitination |
| GO id: | GO:0070534 |
| Definition: | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| Number of paths to term: | 8 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processmacromolecule modificationprotein modification processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processcellular protein metabolic processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processprotein modification processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processprimary metabolic processprotein metabolic processcellular protein metabolic processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processbiological_processmetabolic processprimary metabolic processprotein metabolic processprotein modification processcellular protein modification processprotein modification by small protein conjugation or removalprotein modification by small protein conjugationprotein ubiquitinationprotein polyubiquitinationprotein K11-linked ubiquitinationprotein K27-linked ubiquitinationprotein K29-linked ubiquitinationprotein K48-linked ubiquitinationprotein K6-linked ubiquitinationprotein K63-linked ubiquitination [GO:0070534] (25 genes, 27 annotations)histone H2A K63-linked ubiquitination +negative regulation of protein K63-linked ubiquitination +regulation of protein K63-linked ubiquitination +protein linear polyubiquitinationprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic processMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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