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Gene Ontology Browser
Term Detail
GO term:protein K63-linked ubiquitination
Synonym: protein K63-linked polyubiquitination
GO id:GO:0070534
Definition:A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein modification by small protein conjugation or removal
                                                                is-aprotein modification by small protein conjugation
                                                                        is-aprotein ubiquitination
                                                                                is-aprotein polyubiquitination
                                                                                        negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                        positively-regulatespositive regulation of protein polyubiquitination +
                                                                                        is-aprotein K11-linked ubiquitination
                                                                                        is-aprotein K27-linked ubiquitination
                                                                                        is-aprotein K29-linked ubiquitination
                                                                                        is-aprotein K33-linked ubiquitination
                                                                                        is-aprotein K48-linked ubiquitination +
                                                                                        is-aprotein K6-linked ubiquitination
                                                                                        is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                is-ahistone H2A K63-linked ubiquitination +
                                                                                                negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                regulatesregulation of protein K63-linked ubiquitination +
                                                                                        is-aprotein linear polyubiquitination +
                                                                                        is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                        regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein modification by small protein conjugation or removal
                                                                is-aprotein modification by small protein conjugation
                                                                        is-aprotein ubiquitination
                                                                                is-aprotein polyubiquitination
                                                                                        negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                        positively-regulatespositive regulation of protein polyubiquitination +
                                                                                        is-aprotein K11-linked ubiquitination
                                                                                        is-aprotein K27-linked ubiquitination
                                                                                        is-aprotein K29-linked ubiquitination
                                                                                        is-aprotein K33-linked ubiquitination
                                                                                        is-aprotein K48-linked ubiquitination +
                                                                                        is-aprotein K6-linked ubiquitination
                                                                                        is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                is-ahistone H2A K63-linked ubiquitination +
                                                                                                negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                regulatesregulation of protein K63-linked ubiquitination +
                                                                                        is-aprotein linear polyubiquitination +
                                                                                        is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                        regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-acellular macromolecule metabolic process
                                                is-acellular protein metabolic process
                                                        is-acellular protein modification process
                                                                is-aprotein modification by small protein conjugation or removal
                                                                        is-aprotein modification by small protein conjugation
                                                                                is-aprotein ubiquitination
                                                                                        is-aprotein polyubiquitination
                                                                                                negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                                positively-regulatespositive regulation of protein polyubiquitination +
                                                                                                is-aprotein K11-linked ubiquitination
                                                                                                is-aprotein K27-linked ubiquitination
                                                                                                is-aprotein K29-linked ubiquitination
                                                                                                is-aprotein K33-linked ubiquitination
                                                                                                is-aprotein K48-linked ubiquitination +
                                                                                                is-aprotein K6-linked ubiquitination
                                                                                                is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                        is-ahistone H2A K63-linked ubiquitination +
                                                                                                        negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                        positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                        regulatesregulation of protein K63-linked ubiquitination +
                                                                                                is-aprotein linear polyubiquitination +
                                                                                                is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                                regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-amacromolecule modification
                                                is-aprotein modification process
                                                        is-acellular protein modification process
                                                                is-aprotein modification by small protein conjugation or removal
                                                                        is-aprotein modification by small protein conjugation
                                                                                is-aprotein ubiquitination
                                                                                        is-aprotein polyubiquitination
                                                                                                negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                                positively-regulatespositive regulation of protein polyubiquitination +
                                                                                                is-aprotein K11-linked ubiquitination
                                                                                                is-aprotein K27-linked ubiquitination
                                                                                                is-aprotein K29-linked ubiquitination
                                                                                                is-aprotein K33-linked ubiquitination
                                                                                                is-aprotein K48-linked ubiquitination +
                                                                                                is-aprotein K6-linked ubiquitination
                                                                                                is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                        is-ahistone H2A K63-linked ubiquitination +
                                                                                                        negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                        positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                        regulatesregulation of protein K63-linked ubiquitination +
                                                                                                is-aprotein linear polyubiquitination +
                                                                                                is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                                regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-acellular protein metabolic process
                                                        is-acellular protein modification process
                                                                is-aprotein modification by small protein conjugation or removal
                                                                        is-aprotein modification by small protein conjugation
                                                                                is-aprotein ubiquitination
                                                                                        is-aprotein polyubiquitination
                                                                                                negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                                positively-regulatespositive regulation of protein polyubiquitination +
                                                                                                is-aprotein K11-linked ubiquitination
                                                                                                is-aprotein K27-linked ubiquitination
                                                                                                is-aprotein K29-linked ubiquitination
                                                                                                is-aprotein K33-linked ubiquitination
                                                                                                is-aprotein K48-linked ubiquitination +
                                                                                                is-aprotein K6-linked ubiquitination
                                                                                                is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                        is-ahistone H2A K63-linked ubiquitination +
                                                                                                        negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                        positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                        regulatesregulation of protein K63-linked ubiquitination +
                                                                                                is-aprotein linear polyubiquitination +
                                                                                                is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                                regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein modification process
                                                        is-acellular protein modification process
                                                                is-aprotein modification by small protein conjugation or removal
                                                                        is-aprotein modification by small protein conjugation
                                                                                is-aprotein ubiquitination
                                                                                        is-aprotein polyubiquitination
                                                                                                negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                                positively-regulatespositive regulation of protein polyubiquitination +
                                                                                                is-aprotein K11-linked ubiquitination
                                                                                                is-aprotein K27-linked ubiquitination
                                                                                                is-aprotein K29-linked ubiquitination
                                                                                                is-aprotein K33-linked ubiquitination
                                                                                                is-aprotein K48-linked ubiquitination +
                                                                                                is-aprotein K6-linked ubiquitination
                                                                                                is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                        is-ahistone H2A K63-linked ubiquitination +
                                                                                                        negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                        positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                        regulatesregulation of protein K63-linked ubiquitination +
                                                                                                is-aprotein linear polyubiquitination +
                                                                                                is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                                regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein modification by small protein conjugation or removal
                                                                is-aprotein modification by small protein conjugation
                                                                        is-aprotein ubiquitination
                                                                                is-aprotein polyubiquitination
                                                                                        negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                        positively-regulatespositive regulation of protein polyubiquitination +
                                                                                        is-aprotein K11-linked ubiquitination
                                                                                        is-aprotein K27-linked ubiquitination
                                                                                        is-aprotein K29-linked ubiquitination
                                                                                        is-aprotein K33-linked ubiquitination
                                                                                        is-aprotein K48-linked ubiquitination +
                                                                                        is-aprotein K6-linked ubiquitination
                                                                                        is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                is-ahistone H2A K63-linked ubiquitination +
                                                                                                negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                regulatesregulation of protein K63-linked ubiquitination +
                                                                                        is-aprotein linear polyubiquitination +
                                                                                        is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                        regulatesregulation of protein polyubiquitination +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein modification process
                                                is-acellular protein modification process
                                                        is-aprotein modification by small protein conjugation or removal
                                                                is-aprotein modification by small protein conjugation
                                                                        is-aprotein ubiquitination
                                                                                is-aprotein polyubiquitination
                                                                                        negatively-regulatesnegative regulation of protein polyubiquitination +
                                                                                        positively-regulatespositive regulation of protein polyubiquitination +
                                                                                        is-aprotein K11-linked ubiquitination
                                                                                        is-aprotein K27-linked ubiquitination
                                                                                        is-aprotein K29-linked ubiquitination
                                                                                        is-aprotein K33-linked ubiquitination
                                                                                        is-aprotein K48-linked ubiquitination +
                                                                                        is-aprotein K6-linked ubiquitination
                                                                                        is-aprotein K63-linked ubiquitination [GO:0070534] (35 genes, 38 annotations)
                                                                                                is-ahistone H2A K63-linked ubiquitination +
                                                                                                negatively-regulatesnegative regulation of protein K63-linked ubiquitination +
                                                                                                positively-regulatespositive regulation of protein K63-linked ubiquitination +
                                                                                                regulatesregulation of protein K63-linked ubiquitination +
                                                                                        is-aprotein linear polyubiquitination +
                                                                                        is-aprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
                                                                                        regulatesregulation of protein polyubiquitination +


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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory