Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIMP3
  • Mouse genes Timp3
  • Rat genes Timp3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Timp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TIMP3	IPI	UniProtKB:P50052	Human	PMID:18344519
Molecular Function	GO:0005515	protein binding	TIMP3	IPI	UniProtKB:P78536	Human	PMID:18638486
Cellular Component	GO:0005604	basement membrane	Timp3	IDA		Mouse	PMID:12950084
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP3	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP3	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP3	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP3	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP3	HDA		Human	PMID:28675934
Cellular Component	GO:0005737	cytoplasm	Timp3	IDA		Rat	PMID:17551674|RGD:2290424
Cellular Component	GO:0005615	extracellular space	Timp3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005634	nucleus	TIMP3	HDA		Human	PMID:21630459
Biological Process	GO:0007568	aging	Timp3	IEP		Rat	PMID:16208432|RGD:8694091
Biological Process	GO:0007568	aging	Timp3	IEP		Rat	PMID:18278151|RGD:2290357
Biological Process	GO:0071456	cellular response to hypoxia	Timp3	IEP		Rat	PMID:28854428|RGD:152025191
Biological Process	GO:0071354	cellular response to interleukin-6	Timp3	IEP		Rat	PMID:25484256|RGD:151893491
Biological Process	GO:0071310	cellular response to organic substance	Timp3	IDA		Mouse	PMID:11869290
Biological Process	GO:0007417	central nervous system development	Timp3	IEP		Rat	PMID:11044612|RGD:2290466
Biological Process	GO:1901706	mesenchymal cell differentiation involved in bone development	Timp3	IMP		Rat	PMID:31691506|RGD:151893486
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	TIMP3	IMP		Human	PMID:19962668
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	TIMP3	IMP		Human	PMID:18383040
Biological Process	GO:1904684	negative regulation of metalloendopeptidase activity	Timp3	IMP		Mouse	MGI:MGI:5659805|PMID:24812324
Biological Process	GO:0045861	negative regulation of proteolysis	Timp3	IMP		Rat	PMID:17532789|RGD:2290425
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Timp3	IMP		Rat	PMID:28854428|RGD:152025191
Biological Process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	TIMP3	IMP		Human	PMID:19962668
Biological Process	GO:0043200	response to amino acid	Timp3	IEP		Rat	PMID:17083784|RGD:2290426
Biological Process	GO:0043627	response to estrogen	Timp3	IEP		Rat	PMID:15866537|RGD:1600156
Biological Process	GO:0051593	response to folic acid	Timp3	IEP		Rat	PMID:18156304|RGD:2290422
Biological Process	GO:0009725	response to hormone	Timp3	IEP		Rat	PMID:17275272|RGD:2290459
Biological Process	GO:0009612	response to mechanical stimulus	Timp3	IEP		Rat	PMID:17717962|RGD:2290423
Biological Process	GO:0014070	response to organic cyclic compound	Timp3	IEP		Rat	PMID:15866537|RGD:1600156
Biological Process	GO:0010033	response to organic substance	Timp3	IEP		Rat	PMID:17555880|RGD:2290355
Biological Process	GO:0042246	tissue regeneration	Timp3	IEP		Rat	PMID:16683235|RGD:1600154

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern