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Timp3
Gene Detail
Symbol

Name
ID
Timp3
tissue inhibitor of metalloproteinase 3
MGI:98754
Synonyms
Timp-3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
42.83 cM, cytoband C1-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:86300372-86349506 bp, + strand
From VEGA annotation of GRCm38

  49135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TIMP3
Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp3

Human
homologs
TIMP3, TIMP metallopeptidase inhibitor 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7078
neXtProt AC: NX_P35625

Human Synonyms: HSMRK222, K222, K222TA2, SFD

Human Chr (Location): 22q12.3; chr22:32800816-32863041 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TIMP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
 
Targeted null mice die prematurely with lethargy, ruffled hair, and a hunched posture, displaying impaired bronchiole branching, reduced alveologenesis and abnormal mammary gland involution. Knock-ins harboring a Ser156Cys missense mutation provide a mouse model for Sorsby fundus dystrophy.
 
Human Diseases Modeled in Mice Using Timp3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Timp3 interacts with 376 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to organic substance, negative regulation of endopeptidase activity, ...
Component basement membrane, cytoplasm, ...
Function enzyme inhibitor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (192)    Tissues (63)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
Northern blot 12
Western blot 23
RT-PCR 25
cDNA source data(308)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase timp3    NEW 
Molecular
reagents
All nucleic(321) Genomic(3) cDNA(311) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021184 (Evidence)
Ensembl Gene Model ENSMUSG00000020044 (Evidence)
Entrez Gene 21859 (Evidence)
UniGene 4871
DFCI TC1573014, TC1601505, TC1610420, TC1669531
NIA Mouse Gene Index U011837
Consensus CDS Project CCDS24097.1
International Mouse Phenotyping Consortium Status Timp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021184 VEGA Gene Model | MGI Sequence Detail 49135 C57BL/6J ±  kb
transcript OTTMUST00000050178 VEGA | MGI Sequence Detail 4722 Not Applicable 
polypeptide OTTMUSP00000023387 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(459 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015612 Tissue inhibitor of metalloprotease 3
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016354 metalloproteinase inhibitor 3
References
(Earliest) J:17020 Sun Y, et al., Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res. 1994 Mar 1;54(5):1139-44
(Latest) J:219383 Shimoda M, et al., Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat Cell Biol. 2014 Sep;16(9):889-901
All references(137)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15112, MGD-MRK-15114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory