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Timp3
Gene Detail
 Symbol
Name
ID
Timp3
tissue inhibitor of metalloproteinase 3
MGI:98754
Synonyms Timp-3
Feature Type protein coding gene
Genetic Map
Chromosome 10
42.83 cM, cytoband C1-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:86300372-86349506 bp, + strand
From VEGA annotation of GRCm38

  49135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp3

Human
homologs
Human Homolog TIMP3, TIMP metallopeptidase inhibitor 3
NCBI Gene ID 7078
neXtProt AC  NX_P35625
Human Synonyms  HSMRK222, K222, K222TA2, SFD
Human Chr (Location)  22q12.3; chr22:32800816-32863041 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TIMP3
Alleles
and
phenotypes
All alleles(10) : Targeted(10)
 
Targeted null mice die prematurely with lethargy, ruffled hair, and a hunched posture, displaying impaired bronchiole branching, reduced alveologenesis and abnormal mammary gland involution. Knock-ins harboring a Ser156Cys missense mutation provide a mouse model for Sorsby fundus dystrophy.
 
Human Diseases Modeled Using Mouse Timp3 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to organic substance, negative regulation of membrane protein ectodomain proteolysis, ...
Component basement membrane, cytoplasm, ...
Function enzyme inhibitor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (195)    Tissues (63)    Images (35)
Theiler Stages: 1, 2, 3, 4, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 132
Northern blot 12
Western blot 23
RT-PCR 28
cDNA source data(308)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(321) Genomic(3) cDNA(311) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021184 (Evidence)
Ensembl Gene ModelENSMUSG00000020044 (Evidence)
Entrez Gene21859 (Evidence)
UniGene4871
DFCITC1573014, TC1601505, TC1610420, TC1669531
NIA Mouse Gene IndexU011837
Consensus CDS ProjectCCDS24097.1
International Mouse Knockout Project StatusTimp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021184 VEGA Gene Model | MGI Sequence Detail 49135 C57BL/6J ±  kb
transcript OTTMUST00000050178 VEGA | MGI Sequence Detail 4722 Not Applicable 
polypeptide OTTMUSP00000023387 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(459 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015612 Tissue inhibitor of metalloprotease 3
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016354 metalloproteinase inhibitor 3
References (Earliest) J:17020 Sun Y, et al., Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res. 1994 Mar 1;54(5):1139-44
(Latest) J:193744 Basu R, et al., Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. J Biol Chem. 2012 Dec 28;287(53):44083-96
All references(132)
Other
accession IDs
MGD-MRK-15112, MGD-MRK-15114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory