Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STX2
  • Mouse genes Stx2
  • Rat genes Stx2
  • Zfish genes stx2a,stx2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	Stx2	IPI	UniProtKB:P46096|UniProtKB:Q9R0N8	Mouse	MGI:MGI:3584221|PMID:15774481
Molecular Function	GO:0005515	protein binding	STX2	IPI	UniProtKB:O00186	Human	PMID:12773094
Molecular Function	GO:0005515	protein binding	STX2	IPI	UniProtKB:P61764	Human	PMID:12773094
Molecular Function	GO:0005515	protein binding	Stx2	IPI	UniProtKB:Q9R0N6	Mouse	MGI:MGI:3584221|PMID:15774481
Molecular Function	GO:0005515	protein binding	Stx2	IPI	UniProtKB:Q28288	Mouse	PMID:8774707
Molecular Function	GO:0005515	protein binding	Stx2	IPI	UniProtKB:P21707	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0005515	protein binding	Stx2	IPI	UniProtKB:P50232	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0005515	protein binding	Stx2	IPI	UniProtKB:P61765	Rat	PMID:17442889|RGD:2312426
Molecular Function	GO:0000149	SNARE binding	Stx2	IMP		Rat	PMID:10564647|RGD:1298910
Molecular Function	GO:0005198	structural molecule activity	STX2	IDA		Human	PMID:22226963
Cellular Component	GO:0016323	basolateral plasma membrane	STX2	IDA		Human	PMID:16339081
Cellular Component	GO:0009986	cell surface	Stx2	IDA		Mouse	PMID:11702001
Cellular Component	GO:0005911	cell-cell junction	Stx2	IDA		Mouse	PMID:11702001
Cellular Component	GO:0031410	cytoplasmic vesicle	Stx2	IDA		Mouse	PMID:18321981
Cellular Component	GO:0005615	extracellular space	STX2	IDA		Human	PMID:22226963
Cellular Component	GO:0030027	lamellipodium	STX2	IDA		Human	PMID:21720706
Cellular Component	GO:0045121	membrane raft	Stx2	IDA		Mouse	PMID:11784086
Cellular Component	GO:0030496	midbody	Stx2	IDA		Rat	PMID:12737809|RGD:1298908
Cellular Component	GO:0005886	plasma membrane	STX2	IDA		Human	PMID:21720706
Cellular Component	GO:0032991	protein-containing complex	STX2	IDA		Human	PMID:22226963
Cellular Component	GO:0045202	synapse	Stx2	IDA		Rat	PMID:17110340|RGD:12050113
Cellular Component	GO:0030133	transport vesicle	Stx2	IDA		Rat	PMID:14578858|RGD:1304451
Biological Process	GO:0007340	acrosome reaction	Stx2	IDA		Mouse	MGI:MGI:3584221|PMID:15774481
Biological Process	GO:0030154	cell differentiation	Stx2	IDA		Mouse	PMID:15685636
Biological Process	GO:0034599	cellular response to oxidative stress	STX2	IDA		Human	PMID:22226963
Biological Process	GO:1903575	cornified envelope assembly	STX2	IDA		Human	PMID:22226963
Biological Process	GO:0048546	digestive tract morphogenesis	Stx2	IMP		Rat	PMID:12464668|RGD:1298909
Biological Process	GO:0030855	epithelial cell differentiation	Stx2	IMP		Rat	PMID:12464668|RGD:1298909
Biological Process	GO:0030033	microvillus assembly	Stx2	IDA		Rat	PMID:12464668|RGD:1298909
Biological Process	GO:0061952	midbody abscission	Stx2	IMP		Rat	PMID:12737809|RGD:1298908
Biological Process	GO:0000281	mitotic cytokinesis	Stx2	IMP		Rat	PMID:12737809|RGD:1298908

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern