About   Help   FAQ
Stx2 Gene Detail
Summary
  • Symbol
    Stx2
  • Name
    syntaxin 2
  • Synonyms
    Epim, G1-536-1, repro34, Syn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108059
    NCBI Gene: 13852
  • Gene Overview
    MyGene.info: STX2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:128984557-129008574 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 67.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108059
protein coding gene Chr5:128984557-129008600 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030122
protein coding gene Chr5:133039649-133063640 (-)
A/J MGP_AJ_G0030089
protein coding gene Chr5:127447770-127471896 (-)
AKR/J MGP_AKRJ_G0030023
protein coding gene Chr5:131591964-131615967 (-)
BALB/cJ MGP_BALBcJ_G0030099
protein coding gene Chr5:128794569-128818558 (-)
C3H/HeJ MGP_C3HHeJ_G0029816
protein coding gene Chr5:132160272-132184281 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030552
protein coding gene Chr5:138145421-138169420 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027777
protein coding gene Chr5:121852444-121875006 (-)
CAST/EiJ MGP_CASTEiJ_G0029225
protein coding gene Chr5:131422187-131446469 (-)
CBA/J MGP_CBAJ_G0029786
protein coding gene Chr5:143512697-143536710 (-)
DBA/2J MGP_DBA2J_G0029936
protein coding gene Chr5:127433080-127457245 (-)
FVB/NJ MGP_FVBNJ_G0029892
protein coding gene Chr5:126497843-126521999 (-)
LP/J MGP_LPJ_G0030025
protein coding gene Chr5:133551131-133575135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029923
protein coding gene Chr5:146903412-146927975 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030593
protein coding gene Chr5:131270211-131294362 (-)
PWK/PhJ MGP_PWKPhJ_G0028939
protein coding gene Chr5:126336404-126361126 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028776
protein coding gene Chr5:128837146-128861104 (-)
WSB/EiJ MGP_WSBEiJ_G0029299
protein coding gene Chr5:131922461-131947509 (-)



Homology
more
  • Human Ortholog
    STX2, syntaxin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STX2, syntaxin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPIM, EPM, STX2A, STX2B, STX2C
  • Links
    NCBI Gene ID: 2054
    neXtProt AC: NX_P32856
    UniProt: P32856

  • Chr Location
    12q24.33; chr12:130789600-130839274 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display male infertility associated with abnormal testicular development and impaired spermatogenesis, increased intestinal growth due to enhanced crypt cell proliferation and crypt fission, and decreased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029428 Ensembl Gene Model | MGI Sequence Detail 24018 C57BL/6J ±  kb
    transcript ENSMUST00000031378 Ensembl | MGI Sequence Detail 2939 Not Applicable  
    polypeptide ENSMUSP00000031378 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37095, MGI:2141213, MGI:3692873
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:247024 Zhu D, et al., Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis. Diabetes. 2017 Apr;66(4):948-959

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory