Stx2
Gene Detail

Symbol Name ID

Stx2 syntaxin 2 MGI:108059

Synonyms

Epim, G1-536-1, repro34, Syn-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

67.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:128984557-129008574 bp, - strand From VEGA annotation of GRCm38   24018 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx2

Human homologs

Human Homolog		STX2, syntaxin 2
NCBI Gene ID		2054
neXtProt AC		NX_P32856
Human Synonyms		EPIM, EPM, STX2A, STX2B, STX2C
Human Chr (Location)		12q24.33; chr12:131274145-131323819 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(5) Chemically induced(1)
 

Mice homozygous for a null mutation display male infertility, azoospermia, reduced litter size, and abnormal small intestine, colon, and crypts of Lieberkuhn morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	acrosome reaction, cell differentiation, ...
Component	basolateral plasma membrane, cell-cell junction, ...
Function	calcium-dependent protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (84)    Tissues (18)    Images (30)
Theiler Stages: 1, 2, 3, 4, 21, 23, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	68
RT-PCR	7

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027708 (Evidence)
Ensembl Gene Model	ENSMUSG00000029428 (Evidence)
Entrez Gene	13852 (Evidence)
UniGene	260716
DFCI	TC1578745, TC1624219
DoTS	DT.101258240, DT.110641255, DT.530963, DT.87034450
NIA Mouse Gene Index	U026759
Consensus CDS Project	CCDS19692.1
International Mouse Knockout Project Status	Stx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027708	VEGA Gene Model | MGI Sequence Detail	24018	C57BL/6J
transcript	OTTMUST00000068560	VEGA | MGI Sequence Detail	2939	Not Applicable
polypeptide	OTTMUSP00000034696	VEGA | MGI Sequence Detail	289	Not Applicable

All sequences(47) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(187 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006012	Syntaxin/epimorphin, conserved site
InterPro	IPR006011	Syntaxin, N-terminal
InterPro	IPR000727	Target SNARE coiled-coil domain
InterPro	IPR010989	t-SNARE
Protein Ontology	PR:000015794	syntaxin-2

References

(Earliest) J:37069 Hirai Y, et al., Epimorphin: a mesenchymal protein essential for epithelial morphogenesis [see comments]. Cell. 1992 May 1;69(3):471-81
(Latest) J:189176 Ye S, et al., Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood. 2012 Sep 20;120(12):2484-92
All references(49)

Other accession IDs

MGD-MRK-37095, MGI:2141213, MGI:3692873