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Stx2
Gene Detail
 Symbol
Name
ID
Stx2
syntaxin 2
MGI:108059
Synonyms Epim, G1-536-1, repro34, Syn-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
67.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:128984557-129008574 bp, - strand
From VEGA annotation of GRCm38

  24018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx2

Human
homologs
Human Homolog STX2, syntaxin 2
NCBI Gene ID 2054
neXtProt AC  NX_P32856
Human Synonyms  EPIM, EPM, STX2A, STX2B, STX2C
Human Chr (Location)  12q24.33; chr12:130789600-130839274 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display male infertility, azoospermia, reduced litter size, and abnormal small intestine, colon, and crypts of Lieberkuhn morphology.
 
Interactions
Stx2 interacts with 198 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process acrosome reaction, cell differentiation, ...
Component basolateral plasma membrane, cell-cell junction, ...
Function calcium-dependent protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (84)    Tissues (24)    Images (30)
Theiler Stages: 1, 2, 3, 4, 21, 23, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 68
RT-PCR 7
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027708 (Evidence)
Ensembl Gene ModelENSMUSG00000029428 (Evidence)
Entrez Gene13852 (Evidence)
UniGene260716
DFCITC1578745, TC1624219
DoTSDT.101258240, DT.110641255, DT.530963, DT.87034450
NIA Mouse Gene IndexU026759
Consensus CDS ProjectCCDS19692.1, CCDS71672.1
International Mouse Knockout Project StatusStx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027708 VEGA Gene Model | MGI Sequence Detail 24018 C57BL/6J ±  kb
transcript OTTMUST00000068560 VEGA | MGI Sequence Detail 2939 Not Applicable 
polypeptide OTTMUSP00000034696 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015794 syntaxin-2
References (Earliest) J:37069 Hirai Y, et al., Epimorphin: a mesenchymal protein essential for epithelial morphogenesis [see comments]. Cell. 1992 May 1;69(3):471-81
(Latest) J:210570 Swietlicki EA, et al., Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G564-72
All references(52)
Other
accession IDs
MGD-MRK-37095, MGI:2141213, MGI:3692873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory