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Gene Ontology Browser
Term Detail
GO term:acrosome reaction
GO id:GO:0007340
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
Number of paths to term: 14

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        is-adense core granule exocytosis
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-acellular localization
                                part-ofestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-aestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-asingle-organism transport
                                                is-asecretion
                                                        is-asecretion by cell
                                                                is-aexocytosis
                                                                        is-acalcium ion-dependent exocytosis
                                                                                is-aacrosomal vesicle exocytosis +
                                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                                        part-ofacrosomal vesicle exocytosis +
                                                                                        part-ofacrosome matrix dispersal
                                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                                        part-ofprotein localization involved in acrosome reaction
                                                                                        regulatesregulation of acrosome reaction +
                                                                                is-acortical granule exocytosis +
                                                                                is-adense core granule exocytosis
                                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-avesicle-mediated transport
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aexocytosis
                                                                is-acalcium ion-dependent exocytosis
                                                                        is-aacrosomal vesicle exocytosis +
                                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                                part-ofacrosomal vesicle exocytosis +
                                                                                part-ofacrosome matrix dispersal
                                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                                positively-regulatespositive regulation of acrosome reaction
                                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                                part-ofprotein localization involved in acrosome reaction
                                                                                regulatesregulation of acrosome reaction +
                                                                        is-acortical granule exocytosis +
                                                                        is-adense core granule exocytosis
                                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-amulti-organism process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproduction
                        is-asexual reproduction
                                part-offertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        is-adense core granule exocytosis
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aexocytosis
                                                                is-acalcium ion-dependent exocytosis
                                                                        is-aacrosomal vesicle exocytosis +
                                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                                part-ofacrosomal vesicle exocytosis +
                                                                                part-ofacrosome matrix dispersal
                                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                                positively-regulatespositive regulation of acrosome reaction
                                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                                part-ofprotein localization involved in acrosome reaction
                                                                                regulatesregulation of acrosome reaction +
                                                                        is-acortical granule exocytosis +
                                                                        is-adense core granule exocytosis
                                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism transport
                                is-asecretion
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory