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Gene Ontology Browser
Term Detail
GO term:acrosome reaction
GO id:GO:0007340
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
Number of paths to term: 19

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular process involved in reproduction
                                is-aacrosomal vesicle exocytosis +
                                is-aacrosome matrix dispersal
                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                        part-ofacrosomal vesicle exocytosis +
                                        part-ofacrosome matrix dispersal
                                        part-ofmembrane fusion involved in acrosome reaction
                                        negatively-regulatesnegative regulation of acrosome reaction
                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                        positively-regulatespositive regulation of acrosome reaction
                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                        part-ofprotein localization involved in acrosome reaction
                                        regulatesregulation of acrosome reaction +
                                is-aactivation of MAPK activity involved in conjugation with cellular fusion
                                is-aactivation of MAPKK activity involved in conjugation with cellular fusion
                                is-aagglutination involved in conjugation with cellular fusion
                                is-aanther wall tapetum cell differentiation +
                                is-aanther wall tapetum cell fate specification
                                is-aapical cell fate commitment
                                is-aascospore release from ascus +
                                is-aascospore wall assembly
                                is-aascospore wall beta-glucan metabolic process +
                                is-aascospore wall biogenesis +
                                is-aascospore wall chitin biosynthetic process +
                                is-aascospore-type prospore assembly +
                                is-aascospore-type prospore membrane assembly +
                                is-aascospore-type prospore-specific spindle pole body remodeling
                                is-aasexual spore wall assembly
                                is-aattachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation +
                                is-aattachment of telomeric heterochromatin to nuclear envelope
                                is-aattachment of telomeric heterochromatin to spindle pole body
                                is-acell adhesion involved in prostatic bud elongation
                                is-acell cycle arrest in response to pheromone
                                is-acell migration involved in prostatic bud elongation
                                is-acell morphogenesis involved in conjugation with cellular fusion +
                                is-acell wall disassembly involved in floral organ abscission
                                is-acell wall macromolecule catabolic process involved in cytogamy
                                is-acell wall organization involved in conjugation with cellular fusion
                                is-acellular process involved in reproduction in multicellular organism +
                                is-acentrosomal and pronuclear rotation
                                is-achiasma assembly
                                is-achromosome organization involved in meiosis +
                                is-aconjugation with cellular fusion +
                                is-acortical granule exocytosis +
                                is-adetection of stimulus involved in meiotic DNA replication checkpoint
                                is-adiakinesis
                                is-adiplotene
                                is-aDNA duplex unwinding involved in meiotic DNA replication
                                is-aDNA ligation involved in meiotic DNA replication
                                is-aDNA methylation involved in gamete generation
                                is-aDNA recombinase assembly involved in gene conversion at mating-type locus
                                is-aDNA replication initiation involved in meiotic DNA replication
                                is-aDNA replication termination involved in meiotic DNA replication
                                is-aDNA strand elongation involved in meiotic DNA replication
                                is-adonor selection +
                                is-adynein-driven meiotic oscillatory nuclear movement
                                is-aegg activation +
                                is-aepithelial cell differentiation involved in prostate gland development +
                                is-aepithelial cell maturation involved in prostate gland development
                                is-aepithelial cell proliferation involved in prostate gland development +
                                is-aepithelial-mesenchymal signaling involved in prostate gland development +
                                is-aestablishment of meiotic sister chromatid cohesion
                                is-aestablishment of meiotic spindle localization +
                                is-aextracellular polysaccharide catabolic process involved in ascospore release from ascus +
                                is-afemale pronucleus assembly
                                is-afertilization, exchange of chromosomal proteins
                                is-afruiting body development in cellular response to starvation
                                is-afusome organization +
                                is-agene conversion at mating-type locus +
                                is-agene conversion at mating-type locus, DNA double-strand break formation
                                is-agene conversion at mating-type locus, DNA double-strand break processing
                                is-agene conversion at mating-type locus, DNA repair synthesis
                                is-agene conversion at mating-type locus, termination of copy-synthesis
                                is-aheteroduplex formation involved in gene conversion at mating-type locus
                                is-aHulle cell development +
                                is-ainitiation of premeiotic DNA replication
                                is-akaryogamy involved in conjugation with cellular fusion
                                is-alateral element assembly
                                is-aleptotene
                                is-aLeydig cell differentiation
                                is-alinear element assembly +
                                is-amaintenance of meiotic sister chromatid cohesion +
                                is-amale meiosis centrosome cycle
                                is-amale pronucleus assembly +
                                is-aMAPK import into nucleus involved in conjugation with cellular fusion
                                is-amating pheromone secretion involved in conjugation with cellular fusion
                                is-amating projection assembly +
                                is-amating type determination +
                                is-ameiosis I +
                                is-ameiosis II +
                                is-ameiotic anaphase I
                                is-ameiotic anaphase II
                                is-ameiotic cell cycle +
                                is-ameiotic cell cycle checkpoint +
                                is-ameiotic cell cycle DNA replication
                                is-ameiotic cell cycle phase transition +
                                is-ameiotic cell cycle process +
                                is-ameiotic chromosome movement towards spindle pole +
                                is-ameiotic chromosome segregation +
                                is-ameiotic chromosome separation +
                                is-ameiotic cytokinesis +
                                is-ameiotic DNA double-strand break formation +
                                is-ameiotic DNA double-strand break processing +
                                is-ameiotic DNA recombinase assembly +
                                is-ameiotic DNA repair synthesis +
                                is-ameiotic G1 phase
                                is-ameiotic G2 phase
                                is-ameiotic gene conversion +
                                is-ameiotic heteroduplex formation
                                is-ameiotic interphase +
                                is-ameiotic joint molecule formation +
                                is-ameiotic M phase
                                is-ameiotic metaphase I
                                is-ameiotic metaphase II
                                is-ameiotic metaphase plate congression +
                                is-ameiotic mismatch repair +
                                is-ameiotic nuclear division +
                                is-ameiotic nuclear envelope disassembly +
                                is-ameiotic nuclear envelope reassembly +
                                is-ameiotic prophase I +
                                is-ameiotic prophase II
                                is-ameiotic S phase
                                is-ameiotic sister chromatid arm separation
                                is-ameiotic sister chromatid centromere separation
                                is-ameiotic spindle elongation +
                                is-ameiotic spindle organization +
                                is-ameiotic spindle stabilization
                                is-ameiotic strand displacement +
                                is-ameiotic strand invasion +
                                is-ameiotic telomere maintenance via semi-conservative replication
                                is-ameiotic telophase I
                                is-ameiotic telophase II
                                is-amesenchymal cell proliferation involved in prostate gland development +
                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                is-amesenchymal-epithelial cell signaling involved in prostate gland development +
                                is-ametula development +
                                is-amicrosporocyte differentiation
                                is-amicrotubule cytoskeleton organization involved in synapsis
                                is-amucilage metabolic process involved in seed coat development +
                                is-anuclear migration involved in conjugation with cellular fusion
                                is-anurse cell nucleus anchoring
                                is-aovarian follicle atresia
                                is-apachytene
                                is-aparasexual conjugation with cellular fusion
                                is-apeptide pheromone export involved in conjugation with cellular fusion
                                is-apeptidyl-serine phosphorylation involved in acrosome reaction
                                is-aphialide development +
                                is-aplasma membrane fusion involved in cytogamy
                                is-aplasma membrane organization involved in conjugation with cellular fusion
                                is-apollen adhesion
                                is-apollen tube adhesion
                                is-apollen tube growth +
                                is-apollen-pistil interaction +
                                is-apositive regulation of actin filament polymerization involved in acrosome reaction
                                is-apositive regulation of cytosolic calcium ion concentration involved in egg activation +
                                is-apremeiotic DNA replication +
                                is-apronuclear envelope synthesis +
                                is-apronuclear fusion
                                is-aprotein localization involved in acrosome reaction
                                is-areciprocal meiotic recombination +
                                is-arecognition of pollen +
                                is-arecruitment of helicase-primase complex to DNA lesions
                                is-aregulation of ubiquitin-protein ligase activity involved in meiotic cell cycle +
                                is-aremoval of nonhomologous ends +
                                is-areproductive process in single-celled organism +
                                is-aresponse to meiotic recombination checkpoint signaling
                                is-aresponse to pheromone involved in conjugation with cellular fusion +
                                is-aseed oilbody biogenesis
                                is-aSertoli cell development +
                                is-aSertoli cell differentiation +
                                is-aSertoli cell fate commitment
                                is-aSertoli cell proliferation
                                is-asex determination, somatic-gonadal interaction
                                is-asexual spore wall assembly
                                is-asexual sporulation +
                                is-asignal transduction involved in conjugation with cellular fusion +
                                is-asignal transduction involved in meiotic cell cycle checkpoint +
                                is-asmooth muscle cell differentiation involved in prostate glandular acinus development
                                is-asorocarp spore cell differentiation +
                                is-asorocarp stalk cell differentiation +
                                is-asperm aster formation
                                is-asperm chromatin decondensation +
                                is-asperm entry
                                is-asperm nuclear envelope removal
                                is-asperm-egg recognition +
                                is-aspindle midzone assembly involved in meiosis
                                is-aspore membrane bending pathway
                                is-astrand invasion involved in gene conversion at mating-type locus
                                is-asynergid death
                                is-asynthesis of RNA primer involved in meiotic DNA replication
                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
                                is-atrehalose biosynthetic process involved in ascospore formation
                                is-atrophoblast cell migration +
                                is-avesicle-mediated transport involved in floral organ abscission +
                                is-azygote asymmetric cytokinesis in embryo sac
                                is-azygotene


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-aestablishment of localization
                        is-aestablishment of localization in cell
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-aestablishment of localization
                        is-atransport
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aexocytosis
                                                                is-acalcium ion-dependent exocytosis
                                                                        is-aacrosomal vesicle exocytosis +
                                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                                part-ofacrosomal vesicle exocytosis +
                                                                                part-ofacrosome matrix dispersal
                                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                                positively-regulatespositive regulation of acrosome reaction
                                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                                part-ofprotein localization involved in acrosome reaction
                                                                                regulatesregulation of acrosome reaction +
                                                                        is-acortical granule exocytosis +
                                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-aestablishment of localization
                        is-atransport
                                is-avesicle-mediated transport
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-acellular localization
                                part-ofestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        part-ofestablishment of localization
                                is-aestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        part-ofestablishment of localization
                                is-atransport
                                        is-asingle-organism transport
                                                is-asecretion
                                                        is-asecretion by cell
                                                                is-aexocytosis
                                                                        is-acalcium ion-dependent exocytosis
                                                                                is-aacrosomal vesicle exocytosis +
                                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                                        part-ofacrosomal vesicle exocytosis +
                                                                                        part-ofacrosome matrix dispersal
                                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                                        part-ofprotein localization involved in acrosome reaction
                                                                                        regulatesregulation of acrosome reaction +
                                                                                is-acortical granule exocytosis +
                                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-alocalization
                        part-ofestablishment of localization
                                is-atransport
                                        is-avesicle-mediated transport
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-amulti-organism process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofcellular process involved in reproduction
                                is-aacrosomal vesicle exocytosis +
                                is-aacrosome matrix dispersal
                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                        part-ofacrosomal vesicle exocytosis +
                                        part-ofacrosome matrix dispersal
                                        part-ofmembrane fusion involved in acrosome reaction
                                        negatively-regulatesnegative regulation of acrosome reaction
                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                        positively-regulatespositive regulation of acrosome reaction
                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                        part-ofprotein localization involved in acrosome reaction
                                        regulatesregulation of acrosome reaction +
                                is-aactivation of MAPK activity involved in conjugation with cellular fusion
                                is-aactivation of MAPKK activity involved in conjugation with cellular fusion
                                is-aagglutination involved in conjugation with cellular fusion
                                is-aanther wall tapetum cell differentiation +
                                is-aanther wall tapetum cell fate specification
                                is-aapical cell fate commitment
                                is-aascospore release from ascus +
                                is-aascospore wall assembly
                                is-aascospore wall beta-glucan metabolic process +
                                is-aascospore wall biogenesis +
                                is-aascospore wall chitin biosynthetic process +
                                is-aascospore-type prospore assembly +
                                is-aascospore-type prospore membrane assembly +
                                is-aascospore-type prospore-specific spindle pole body remodeling
                                is-aasexual spore wall assembly
                                is-aattachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation +
                                is-aattachment of telomeric heterochromatin to nuclear envelope
                                is-aattachment of telomeric heterochromatin to spindle pole body
                                is-acell adhesion involved in prostatic bud elongation
                                is-acell cycle arrest in response to pheromone
                                is-acell migration involved in prostatic bud elongation
                                is-acell morphogenesis involved in conjugation with cellular fusion +
                                is-acell wall disassembly involved in floral organ abscission
                                is-acell wall macromolecule catabolic process involved in cytogamy
                                is-acell wall organization involved in conjugation with cellular fusion
                                is-acellular process involved in reproduction in multicellular organism +
                                is-acentrosomal and pronuclear rotation
                                is-achiasma assembly
                                is-achromosome organization involved in meiosis +
                                is-aconjugation with cellular fusion +
                                is-acortical granule exocytosis +
                                is-adetection of stimulus involved in meiotic DNA replication checkpoint
                                is-adiakinesis
                                is-adiplotene
                                is-aDNA duplex unwinding involved in meiotic DNA replication
                                is-aDNA ligation involved in meiotic DNA replication
                                is-aDNA methylation involved in gamete generation
                                is-aDNA recombinase assembly involved in gene conversion at mating-type locus
                                is-aDNA replication initiation involved in meiotic DNA replication
                                is-aDNA replication termination involved in meiotic DNA replication
                                is-aDNA strand elongation involved in meiotic DNA replication
                                is-adonor selection +
                                is-adynein-driven meiotic oscillatory nuclear movement
                                is-aegg activation +
                                is-aepithelial cell differentiation involved in prostate gland development +
                                is-aepithelial cell maturation involved in prostate gland development
                                is-aepithelial cell proliferation involved in prostate gland development +
                                is-aepithelial-mesenchymal signaling involved in prostate gland development +
                                is-aestablishment of meiotic sister chromatid cohesion
                                is-aestablishment of meiotic spindle localization +
                                is-aextracellular polysaccharide catabolic process involved in ascospore release from ascus +
                                is-afemale pronucleus assembly
                                is-afertilization, exchange of chromosomal proteins
                                is-afruiting body development in cellular response to starvation
                                is-afusome organization +
                                is-agene conversion at mating-type locus +
                                is-agene conversion at mating-type locus, DNA double-strand break formation
                                is-agene conversion at mating-type locus, DNA double-strand break processing
                                is-agene conversion at mating-type locus, DNA repair synthesis
                                is-agene conversion at mating-type locus, termination of copy-synthesis
                                is-aheteroduplex formation involved in gene conversion at mating-type locus
                                is-aHulle cell development +
                                is-ainitiation of premeiotic DNA replication
                                is-akaryogamy involved in conjugation with cellular fusion
                                is-alateral element assembly
                                is-aleptotene
                                is-aLeydig cell differentiation
                                is-alinear element assembly +
                                is-amaintenance of meiotic sister chromatid cohesion +
                                is-amale meiosis centrosome cycle
                                is-amale pronucleus assembly +
                                is-aMAPK import into nucleus involved in conjugation with cellular fusion
                                is-amating pheromone secretion involved in conjugation with cellular fusion
                                is-amating projection assembly +
                                is-amating type determination +
                                is-ameiosis I +
                                is-ameiosis II +
                                is-ameiotic anaphase I
                                is-ameiotic anaphase II
                                is-ameiotic cell cycle +
                                is-ameiotic cell cycle checkpoint +
                                is-ameiotic cell cycle DNA replication
                                is-ameiotic cell cycle phase transition +
                                is-ameiotic cell cycle process +
                                is-ameiotic chromosome movement towards spindle pole +
                                is-ameiotic chromosome segregation +
                                is-ameiotic chromosome separation +
                                is-ameiotic cytokinesis +
                                is-ameiotic DNA double-strand break formation +
                                is-ameiotic DNA double-strand break processing +
                                is-ameiotic DNA recombinase assembly +
                                is-ameiotic DNA repair synthesis +
                                is-ameiotic G1 phase
                                is-ameiotic G2 phase
                                is-ameiotic gene conversion +
                                is-ameiotic heteroduplex formation
                                is-ameiotic interphase +
                                is-ameiotic joint molecule formation +
                                is-ameiotic M phase
                                is-ameiotic metaphase I
                                is-ameiotic metaphase II
                                is-ameiotic metaphase plate congression +
                                is-ameiotic mismatch repair +
                                is-ameiotic nuclear division +
                                is-ameiotic nuclear envelope disassembly +
                                is-ameiotic nuclear envelope reassembly +
                                is-ameiotic prophase I +
                                is-ameiotic prophase II
                                is-ameiotic S phase
                                is-ameiotic sister chromatid arm separation
                                is-ameiotic sister chromatid centromere separation
                                is-ameiotic spindle elongation +
                                is-ameiotic spindle organization +
                                is-ameiotic spindle stabilization
                                is-ameiotic strand displacement +
                                is-ameiotic strand invasion +
                                is-ameiotic telomere maintenance via semi-conservative replication
                                is-ameiotic telophase I
                                is-ameiotic telophase II
                                is-amesenchymal cell proliferation involved in prostate gland development +
                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                is-amesenchymal-epithelial cell signaling involved in prostate gland development +
                                is-ametula development +
                                is-amicrosporocyte differentiation
                                is-amicrotubule cytoskeleton organization involved in synapsis
                                is-amucilage metabolic process involved in seed coat development +
                                is-anuclear migration involved in conjugation with cellular fusion
                                is-anurse cell nucleus anchoring
                                is-aovarian follicle atresia
                                is-apachytene
                                is-aparasexual conjugation with cellular fusion
                                is-apeptide pheromone export involved in conjugation with cellular fusion
                                is-apeptidyl-serine phosphorylation involved in acrosome reaction
                                is-aphialide development +
                                is-aplasma membrane fusion involved in cytogamy
                                is-aplasma membrane organization involved in conjugation with cellular fusion
                                is-apollen adhesion
                                is-apollen tube adhesion
                                is-apollen tube growth +
                                is-apollen-pistil interaction +
                                is-apositive regulation of actin filament polymerization involved in acrosome reaction
                                is-apositive regulation of cytosolic calcium ion concentration involved in egg activation +
                                is-apremeiotic DNA replication +
                                is-apronuclear envelope synthesis +
                                is-apronuclear fusion
                                is-aprotein localization involved in acrosome reaction
                                is-areciprocal meiotic recombination +
                                is-arecognition of pollen +
                                is-arecruitment of helicase-primase complex to DNA lesions
                                is-aregulation of ubiquitin-protein ligase activity involved in meiotic cell cycle +
                                is-aremoval of nonhomologous ends +
                                is-areproductive process in single-celled organism +
                                is-aresponse to meiotic recombination checkpoint signaling
                                is-aresponse to pheromone involved in conjugation with cellular fusion +
                                is-aseed oilbody biogenesis
                                is-aSertoli cell development +
                                is-aSertoli cell differentiation +
                                is-aSertoli cell fate commitment
                                is-aSertoli cell proliferation
                                is-asex determination, somatic-gonadal interaction
                                is-asexual spore wall assembly
                                is-asexual sporulation +
                                is-asignal transduction involved in conjugation with cellular fusion +
                                is-asignal transduction involved in meiotic cell cycle checkpoint +
                                is-asmooth muscle cell differentiation involved in prostate glandular acinus development
                                is-asorocarp spore cell differentiation +
                                is-asorocarp stalk cell differentiation +
                                is-asperm aster formation
                                is-asperm chromatin decondensation +
                                is-asperm entry
                                is-asperm nuclear envelope removal
                                is-asperm-egg recognition +
                                is-aspindle midzone assembly involved in meiosis
                                is-aspore membrane bending pathway
                                is-astrand invasion involved in gene conversion at mating-type locus
                                is-asynergid death
                                is-asynthesis of RNA primer involved in meiotic DNA replication
                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
                                is-atrehalose biosynthetic process involved in ascospore formation
                                is-atrophoblast cell migration +
                                is-avesicle-mediated transport involved in floral organ abscission +
                                is-azygote asymmetric cytokinesis in embryo sac
                                is-azygotene


Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofreproductive process
                                is-amulti-organism reproductive process
                                        is-asexual reproduction
                                                part-offertilization
                                                        is-asingle fertilization
                                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                part-ofcentrosomal and pronuclear rotation
                                                                part-ofegg activation +
                                                                part-offemale pronucleus assembly
                                                                part-offusion of sperm to egg plasma membrane +
                                                                part-ofmale pronucleus assembly +
                                                                part-ofpenetration of zona pellucida
                                                                part-ofpronuclear envelope synthesis +
                                                                part-ofpronuclear fusion
                                                                part-ofpronuclear migration
                                                                part-ofrespiratory burst at fertilization
                                                                part-ofsperm aster formation
                                                                part-ofsperm entry
                                                                part-ofsperm plasma membrane disassembly
                                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofreproductive process
                                is-asingle organism reproductive process
                                        is-afertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproduction
                        is-asexual reproduction
                                part-offertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-acalcium ion-dependent exocytosis
                                                        is-aacrosomal vesicle exocytosis +
                                                        is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        is-acortical granule exocytosis +
                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                        is-azymogen granule exocytosis


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism transport
                                is-asecretion
                                        is-asecretion by cell
                                                is-aexocytosis
                                                        is-acalcium ion-dependent exocytosis
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-aacrosome reaction [GO:0007340] (24 genes, 29 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                is-acortical granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-azymogen granule exocytosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory