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Gene Ontology Browser
Term Detail
GO term:acrosome reaction
GO id:GO:0007340
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-amulti-organism process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction +
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofreproductive process
                                is-aacrosome matrix dispersal
                                is-aacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                        part-ofacrosomal vesicle exocytosis +
                                        part-ofacrosome matrix dispersal
                                        part-ofmembrane fusion involved in acrosome reaction
                                        negatively-regulatesnegative regulation of acrosome reaction
                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                        positively-regulatespositive regulation of acrosome reaction +
                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                        part-ofprotein localization involved in acrosome reaction
                                        regulatesregulation of acrosome reaction +
                                is-aactivation of meiosis involved in egg activation
                                is-aadaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion +
                                is-abicoid mRNA localization +
                                is-aborder follicle cell delamination +
                                is-abudding cell bud growth +
                                is-acell adhesion involved in prostatic bud elongation
                                is-acell wall macromolecule catabolic process involved in cytogamy
                                is-acell wall organization involved in conjugation with cellular fusion +
                                is-achromosome localization to nuclear envelope involved in homologous chromosome segregation +
                                is-acytoplasmic transport, nurse cell to oocyte +
                                is-adetection of stimulus involved in meiotic cell cycle checkpoint +
                                is-adetection of stimulus involved in meiotic spindle checkpoint +
                                is-adevelopmental process involved in reproduction +
                                is-aDNA methylation involved in gamete generation
                                is-aDNA recombinase assembly involved in gene conversion at mating-type locus
                                is-aestablishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification +
                                is-afemale germline ring canal formation, actin assembly
                                is-afemale pronucleus assembly
                                is-afertilization, exchange of chromosomal proteins
                                is-aFtsZ-dependent cytokinesis +
                                is-afusome organization +
                                is-agene conversion at mating-type locus +
                                is-agene conversion at mating-type locus, DNA double-strand break formation
                                is-agene conversion at mating-type locus, DNA double-strand break processing
                                is-agene conversion at mating-type locus, DNA repair synthesis
                                is-agene conversion at mating-type locus, termination of copy-synthesis
                                is-agenerative cell mitosis
                                is-aheteroduplex formation involved in gene conversion at mating-type locus
                                is-akaryogamy involved in conjugation with cellular fusion
                                is-akaryosome formation
                                is-aluteinizing hormone signaling pathway involved in ovarian follicle development
                                is-amaintenance of floral organ identity
                                is-amale pronucleus assembly +
                                is-amanchette assembly
                                is-ameiotic cell cycle process +
                                is-amesenchymal smoothened signaling pathway involved in prostate gland development
                                is-amitotic cell cycle arrest in response to pheromone
                                is-amucilage metabolic process involved in seed coat development +
                                is-amulti-organism reproductive process +
                                is-amulticellular organismal reproductive process +
                                is-anegative regulation of progesterone biosynthesis involved in luteolysis
                                negatively-regulatesnegative regulation of reproductive process +
                                is-anurse cell nucleus anchoring
                                is-aoocyte localization involved in germarium-derived egg chamber formation
                                is-aoocyte nucleus localization involved in oocyte dorsal/ventral axis specification +
                                is-aP granule organization +
                                is-apeptide mating pheromone maturation involved in conjugation with cellular fusion
                                is-apeptidyl-serine phosphorylation involved in acrosome reaction
                                is-aphotoperiodism, flowering +
                                is-apole plasm protein localization
                                is-apole plasm RNA localization +
                                is-apollen tube guidance
                                is-apositive regulation of flagellated sperm motility involved in capacitation
                                positively-regulatespositive regulation of reproductive process +
                                is-apositive regulation of transcription involved in egg activation
                                is-aprevention of polyspermy +
                                is-apronuclear fusion
                                is-apronuclear migration
                                is-aprotein localization to meiotic spindle pole body +
                                regulatesregulation of reproductive process +
                                is-aregulation of transcription from RNA polymerase II promoter involved in spermatogenesis
                                is-aregulation of transcription involved in meiotic cell cycle +
                                is-areproductive process in single-celled organism +
                                is-aresponse to pheromone involved in conjugation with cellular fusion +
                                is-asecondary cell wall biogenesis involved in seed trichome differentiation
                                is-aseed oilbody biogenesis
                                is-asignal transduction involved in conjugation with cellular fusion +
                                is-asignal transduction involved in meiotic cell cycle checkpoint +
                                is-asingle organism reproductive process +
                                is-asperm chromatin condensation +
                                is-asperm chromatin decondensation +
                                is-aspermatid nucleus differentiation +
                                is-aspermatid nucleus elongation
                                is-aspermatogenesis, exchange of chromosomal proteins
                                is-astrand invasion involved in gene conversion at mating-type locus
                                is-atransmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
                                is-aWnt signaling pathway involved in animal/vegetal axis specification


obsolete Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofreproductive process
                                is-amulti-organism reproductive process
                                        is-asexual reproduction
                                                part-offertilization
                                                        is-asingle fertilization
                                                                part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                                        part-ofacrosomal vesicle exocytosis +
                                                                        part-ofacrosome matrix dispersal
                                                                        part-ofmembrane fusion involved in acrosome reaction
                                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                        positively-regulatespositive regulation of acrosome reaction +
                                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                        part-ofprotein localization involved in acrosome reaction
                                                                        regulatesregulation of acrosome reaction +
                                                                part-ofcentrosomal and pronuclear rotation
                                                                part-ofegg activation +
                                                                part-offemale pronucleus assembly
                                                                part-offusion of sperm to egg plasma membrane +
                                                                part-ofmale pronucleus assembly +
                                                                part-ofpenetration of zona pellucida
                                                                part-ofpronuclear envelope synthesis +
                                                                part-ofpronuclear fusion
                                                                part-ofpronuclear migration
                                                                part-ofrespiratory burst at fertilization
                                                                part-ofsperm aster formation
                                                                part-ofsperm entry
                                                                part-ofsperm plasma membrane disassembly
                                                                part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-areproduction
                        part-ofreproductive process
                                is-asingle organism reproductive process
                                        is-afertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction +
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-areproduction
                        is-asexual reproduction
                                part-offertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction +
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-aacrosome matrix dispersal
                        is-aacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                part-ofacrosomal vesicle exocytosis +
                                part-ofacrosome matrix dispersal
                                part-ofmembrane fusion involved in acrosome reaction
                                negatively-regulatesnegative regulation of acrosome reaction
                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                positively-regulatespositive regulation of acrosome reaction +
                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                part-ofprotein localization involved in acrosome reaction
                                regulatesregulation of acrosome reaction +
                        is-aactivation of meiosis involved in egg activation
                        is-aadaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion +
                        is-abicoid mRNA localization +
                        is-aborder follicle cell delamination +
                        is-abudding cell bud growth +
                        is-acell adhesion involved in prostatic bud elongation
                        is-acell wall macromolecule catabolic process involved in cytogamy
                        is-acell wall organization involved in conjugation with cellular fusion +
                        is-achromosome localization to nuclear envelope involved in homologous chromosome segregation +
                        is-acytoplasmic transport, nurse cell to oocyte +
                        is-adetection of stimulus involved in meiotic cell cycle checkpoint +
                        is-adetection of stimulus involved in meiotic spindle checkpoint +
                        is-adevelopmental process involved in reproduction +
                        is-aDNA methylation involved in gamete generation
                        is-aDNA recombinase assembly involved in gene conversion at mating-type locus
                        is-aestablishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification +
                        is-afemale germline ring canal formation, actin assembly
                        is-afemale pronucleus assembly
                        is-afertilization, exchange of chromosomal proteins
                        is-aFtsZ-dependent cytokinesis +
                        is-afusome organization +
                        is-agene conversion at mating-type locus +
                        is-agene conversion at mating-type locus, DNA double-strand break formation
                        is-agene conversion at mating-type locus, DNA double-strand break processing
                        is-agene conversion at mating-type locus, DNA repair synthesis
                        is-agene conversion at mating-type locus, termination of copy-synthesis
                        is-agenerative cell mitosis
                        is-aheteroduplex formation involved in gene conversion at mating-type locus
                        is-akaryogamy involved in conjugation with cellular fusion
                        is-akaryosome formation
                        is-aluteinizing hormone signaling pathway involved in ovarian follicle development
                        is-amaintenance of floral organ identity
                        is-amale pronucleus assembly +
                        is-amanchette assembly
                        is-ameiotic cell cycle process +
                        is-amesenchymal smoothened signaling pathway involved in prostate gland development
                        is-amitotic cell cycle arrest in response to pheromone
                        is-amucilage metabolic process involved in seed coat development +
                        is-amulti-organism reproductive process +
                        is-amulticellular organismal reproductive process +
                        is-anegative regulation of progesterone biosynthesis involved in luteolysis
                        negatively-regulatesnegative regulation of reproductive process +
                        is-anurse cell nucleus anchoring
                        is-aoocyte localization involved in germarium-derived egg chamber formation
                        is-aoocyte nucleus localization involved in oocyte dorsal/ventral axis specification +
                        is-aP granule organization +
                        is-apeptide mating pheromone maturation involved in conjugation with cellular fusion
                        is-apeptidyl-serine phosphorylation involved in acrosome reaction
                        is-aphotoperiodism, flowering +
                        is-apole plasm protein localization
                        is-apole plasm RNA localization +
                        is-apollen tube guidance
                        is-apositive regulation of flagellated sperm motility involved in capacitation
                        positively-regulatespositive regulation of reproductive process +
                        is-apositive regulation of transcription involved in egg activation
                        is-aprevention of polyspermy +
                        is-apronuclear fusion
                        is-apronuclear migration
                        is-aprotein localization to meiotic spindle pole body +
                        regulatesregulation of reproductive process +
                        is-aregulation of transcription from RNA polymerase II promoter involved in spermatogenesis
                        is-aregulation of transcription involved in meiotic cell cycle +
                        is-areproductive process in single-celled organism +
                        is-aresponse to pheromone involved in conjugation with cellular fusion +
                        is-asecondary cell wall biogenesis involved in seed trichome differentiation
                        is-aseed oilbody biogenesis
                        is-asignal transduction involved in conjugation with cellular fusion +
                        is-asignal transduction involved in meiotic cell cycle checkpoint +
                        is-asingle organism reproductive process +
                        is-asperm chromatin condensation +
                        is-asperm chromatin decondensation +
                        is-aspermatid nucleus differentiation +
                        is-aspermatid nucleus elongation
                        is-aspermatogenesis, exchange of chromosomal proteins
                        is-astrand invasion involved in gene conversion at mating-type locus
                        is-atransmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
                        is-aWnt signaling pathway involved in animal/vegetal axis specification


obsolete Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-amulti-organism reproductive process
                                is-asexual reproduction
                                        part-offertilization
                                                is-asingle fertilization
                                                        part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                                part-ofacrosomal vesicle exocytosis +
                                                                part-ofacrosome matrix dispersal
                                                                part-ofmembrane fusion involved in acrosome reaction
                                                                negatively-regulatesnegative regulation of acrosome reaction
                                                                part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                                positively-regulatespositive regulation of acrosome reaction +
                                                                part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                                part-ofprotein localization involved in acrosome reaction
                                                                regulatesregulation of acrosome reaction +
                                                        part-ofcentrosomal and pronuclear rotation
                                                        part-ofegg activation +
                                                        part-offemale pronucleus assembly
                                                        part-offusion of sperm to egg plasma membrane +
                                                        part-ofmale pronucleus assembly +
                                                        part-ofpenetration of zona pellucida
                                                        part-ofpronuclear envelope synthesis +
                                                        part-ofpronuclear fusion
                                                        part-ofpronuclear migration
                                                        part-ofrespiratory burst at fertilization
                                                        part-ofsperm aster formation
                                                        part-ofsperm entry
                                                        part-ofsperm plasma membrane disassembly
                                                        part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-areproductive process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction +
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism reproductive process
                                is-afertilization
                                        is-asingle fertilization
                                                part-ofacrosome reaction [GO:0007340] (34 genes, 40 annotations)
                                                        part-ofacrosomal vesicle exocytosis +
                                                        part-ofacrosome matrix dispersal
                                                        part-ofmembrane fusion involved in acrosome reaction
                                                        negatively-regulatesnegative regulation of acrosome reaction
                                                        part-ofpeptidyl-serine phosphorylation involved in acrosome reaction
                                                        positively-regulatespositive regulation of acrosome reaction +
                                                        part-ofpositive regulation of actin filament polymerization involved in acrosome reaction
                                                        part-ofprotein localization involved in acrosome reaction
                                                        regulatesregulation of acrosome reaction +
                                                part-ofcentrosomal and pronuclear rotation
                                                part-ofegg activation +
                                                part-offemale pronucleus assembly
                                                part-offusion of sperm to egg plasma membrane +
                                                part-ofmale pronucleus assembly +
                                                part-ofpenetration of zona pellucida
                                                part-ofpronuclear envelope synthesis +
                                                part-ofpronuclear fusion
                                                part-ofpronuclear migration
                                                part-ofrespiratory burst at fertilization
                                                part-ofsperm aster formation
                                                part-ofsperm entry
                                                part-ofsperm plasma membrane disassembly
                                                part-ofsperm-egg recognition +


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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory