Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX6
  • Mouse genes Sox6
  • Rat genes Sox6
  • Zfish genes sox6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Sox6	IDA		Rat	PMID:26150426|RGD:11526869
Molecular Function	GO:0003677	DNA binding	Sox6	IDA		Mouse	MGI:MGI:5009531|PMID:18403418
Molecular Function	GO:0003677	DNA binding	Sox6	IDA		Mouse	PMID:12446692
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SOX6	IMP		Human	PMID:32442410
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox6	IDA		Mouse	PMID:12446692
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox6	IDA		Mouse	PMID:17084361
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox6	IGI	MGI:MGI:98367	Mouse	PMID:9755172
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	Sox6	IDA		Mouse	MGI:MGI:5766856|PMID:26525805
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Sox6	IMP		Mouse	MGI:MGI:3692153|PMID:16462943
Molecular Function	GO:0005515	protein binding	SOX6	IPI	UniProtKB:O15266	Human	PMID:21262861
Molecular Function	GO:0005515	protein binding	Sox6	IPI	UniProtKB:P35222|UniProtKB:Q02248	Mouse	MGI:MGI:7327233|PMID:26893351
Molecular Function	GO:0005515	protein binding	Sox6	IPI	PR:P35710-2	Mouse	PMID:9755172
Molecular Function	GO:0005515	protein binding	Sox6	IPI	PR:Q9DCP9	Mouse	PMID:14530442
Molecular Function	GO:0005515	protein binding	Sox6	IPI	PR:Q9ESN5	Mouse	PMID:10996314
Molecular Function	GO:0005515	protein binding	Sox6	IPI	PR:P35710	Mouse	PMID:17084361
Molecular Function	GO:0042803	protein homodimerization activity	SOX6	IMP		Human	PMID:32442410
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox6	IMP		Mouse	MGI:MGI:3692153|PMID:16462943
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox6	IDA		Mouse	PMID:27880909
Molecular Function	GO:0043565	sequence-specific DNA binding	Sox6	IDA		Mouse	PMID:16462943
Molecular Function	GO:0000976	transcription cis-regulatory region binding	SOX6	IDA		Human	PMID:26525805
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox6	IDA		Mouse	PMID:17084361
Cellular Component	GO:0005654	nucleoplasm	SOX6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SOX6	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	SOX6	IMP		Human	PMID:32442410
Cellular Component	GO:0005634	nucleus	Sox6	IDA		Mouse	PMID:9755172
Cellular Component	GO:0005634	nucleus	Sox6	IDA		Mouse	PMID:21884692
Biological Process	GO:0060612	adipose tissue development	sox6	IMP	ZFIN:ZDB-GENO-150730-4	Zfish	PMID:26893351
Biological Process	GO:0048708	astrocyte differentiation	Sox6	IMP		Rat	PMID:15846364|RGD:1581115
Biological Process	GO:0007420	brain development	SOX6	IDA		Human	PMID:32442410
Biological Process	GO:0055007	cardiac muscle cell differentiation	Sox6	IDA		Mouse	PMID:14530442
Biological Process	GO:0001502	cartilage condensation	Sox6	IMP		Mouse	MGI:MGI:3037234|PMID:14993235
Biological Process	GO:0001502	cartilage condensation	Sox6	IMP		Mouse	MGI:MGI:2446758|PMID:11702786
Biological Process	GO:0051216	cartilage development	Sox6	IMP		Mouse	MGI:MGI:5780653|PMID:26150426
Biological Process	GO:0051216	cartilage development	Sox6	IDA		Mouse	MGI:MGI:6414706|PMID:15529345
Biological Process	GO:0051216	cartilage development	Sox6	IGI	MGI:MGI:98367	Mouse	PMID:15634692
Biological Process	GO:0045165	cell fate commitment	Sox6	IGI	MGI:MGI:98367	Mouse	PMID:15634692
Biological Process	GO:0000902	cell morphogenesis	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	SOX6	IDA		Human	PMID:21401405
Biological Process	GO:0002062	chondrocyte differentiation	Sox6	IMP		Mouse	MGI:MGI:3037234|PMID:14993235
Biological Process	GO:0002062	chondrocyte differentiation	Sox6	IMP		Mouse	MGI:MGI:2446758|PMID:11702786
Biological Process	GO:0048821	erythrocyte development	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0030218	erythrocyte differentiation	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:20711497
Biological Process	GO:0030218	erythrocyte differentiation	Sox6	IMP	MGI:MGI:3641204	Mouse	PMID:20711497
Biological Process	GO:0010467	gene expression	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:27880909
Biological Process	GO:0030097	hemopoiesis	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0001701	in utero embryonic development	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:17084361
Biological Process	GO:0042694	muscle cell fate specification	sox6	IMP	ZFIN:ZDB-GENO-150730-3	Zfish	PMID:25671076
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	SOX6	IMP		Human	PMID:20081117
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sox6	IDA		Mouse	PMID:17084361
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sox6	IDA		Mouse	PMID:16462943
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0021778	oligodendrocyte cell fate specification	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:17084361
Biological Process	GO:0048709	oligodendrocyte differentiation	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:17084361
Biological Process	GO:0061036	positive regulation of cartilage development	SOX6	IDA		Human	PMID:21401405
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	SOX6	IDA		Human	PMID:21401405
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Sox6	IDA		Mouse	MGI:MGI:5285147|PMID:20940257
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox6	IDA		Mouse	PMID:17084361
Biological Process	GO:2000741	positive regulation of mesenchymal stem cell differentiation	SOX6	IDA		Human	PMID:21401405
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox6	IGI	MGI:MGI:98371	Mouse	PMID:9755172
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox6	IGI	MGI:MGI:98367	Mouse	PMID:9755172
Biological Process	GO:0009791	post-embryonic development	Sox6	IMP	MGI:MGI:2681117	Mouse	PMID:16462943
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:27880909
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sox6	IDA		Mouse	PMID:12446692
Biological Process	GO:0010468	regulation of gene expression	Sox6	IMP	MGI:MGI:3641204	Mouse	PMID:20711497
Biological Process	GO:0010468	regulation of gene expression	Sox6	IMP	MGI:MGI:2447148	Mouse	PMID:20711497
Biological Process	GO:0007519	skeletal muscle tissue development	sox6	IGI	ZFIN:ZDB-MRPHLNO-081223-1,ZFIN:ZDB-MRPHLNO-130425-1	Zfish	PMID:27880909
Biological Process	GO:0007519	skeletal muscle tissue development	sox6	IMP	ZFIN:ZDB-MRPHLNO-081223-1	Zfish	PMID:27880909
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	Sox6	IMP		Mouse	MGI:MGI:5766856|PMID:26525805

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern