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Sox6 Gene Detail
Summary
  • Symbol
    Sox6
  • Name
    SRY (sex determining region Y)-box 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:98368
    NCBI Gene: 20679
  • Gene Overview
    MyGene.info: SOX6
Location & Maps
more
  • Sequence Map
    Chr7:115470872-116038796 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      567925 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 61.29 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    SOX6, SRY-box 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOX6, SRY-box 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSSOX6, SOXD
  • Links
    NCBI Gene ID: 55553
    neXtProt AC: NX_P35712

  • Chr Location
    11p15.3; chr11:15966449-16476388 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    1 involving Sox6
  • Incidental Mutations
Homozygotes for null mutations exhibit cardioskeletal myopathy, cardiac blockage, delayed growth, and early postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058723 VEGA Gene Model | MGI Sequence Detail 567925 C57BL/6J ±  kb
transcript OTTMUST00000144266 VEGA | MGI Sequence Detail 2863 Not Applicable  
polypeptide OTTMUSP00000075222 VEGA | MGI Sequence Detail 828 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3810 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015432 transcription factor SOX-6
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR027153 Transcription factor SOX-6
Molecular
Reagents
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  • All nucleic 29
    Genomic 1
    cDNA 22
    Primer pair 6

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-14507, MGI:2142080
References
more
  • Summaries
    All 108
    Developmental Gene Expression 61
    Gene Ontology 14
    Phenotypes 27
  • Earliest
    J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
  • Latest
    J:233766 Jiang Q, et al., Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016 Jul;31(7):1391-404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory