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Sox6
Gene Detail
Symbol

Name
ID
Sox6
SRY (sex determining region Y)-box 6
MGI:98368
Feature Type
protein coding gene
Genetic Map
Chromosome 7
61.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:115471344-116038744 bp, - strand
From Ensembl annotation of GRCm38

  567401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOX6
Protein SuperFamily: transcription factor Sox5/Sox6/Sox13
Gene Tree: Sox6

Human
homologs
SOX6, SRY (sex determining region Y)-box 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55553
neXtProt AC: NX_P35712

Human Synonyms: HSSOX6, SOXD

Human Chr (Location): 11p15.3; chr11:15966449-16476388 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null mutations exhibit cardioskeletal myopathy, cardiac blockage, delayed growth, and early postnatal lethality.
 
Interactions
Sox6 interacts with 532 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process astrocyte differentiation, cardiac muscle cell differentiation, ...
Component nucleoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (203)    Tissues (135)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
In situ reporter (knock in) 6
Northern blot 30
Western blot 4
RT-PCR 61
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX6 ; Xenbase sox6 ; ZFIN sox6    NEW 
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(22) Primer pair(6)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000051910 (Evidence)
Entrez Gene 20679 (Evidence)
DFCI TC1581580, TC1596307, TC1600084
DoTS DT.101735451, DT.40158115, DT.94141790, DT.97360110
NIA Mouse Gene Index U029157
Consensus CDS Project CCDS40097.1, CCDS40098.1, CCDS52369.1
International Mouse Phenotyping Consortium Status Sox6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051910 Ensembl Gene Model | MGI Sequence Detail 567401 C57BL/6J ±  kb
transcript ENSMUST00000072804 Ensembl | MGI Sequence Detail 8227 Not Applicable 
polypeptide ENSMUSP00000072583 Ensembl | MGI Sequence Detail 827 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(60) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(3832 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR027153 Transcription factor Sox-6
Protein Ontology PR:000015432 transcription factor SOX-6
References
(Earliest) J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
(Latest) J:219841 Qin X, et al., Cbfb regulates bone development by stabilizing runx family proteins. J Bone Miner Res. 2015 Apr;30(4):706-14
All references(102)
Other
accession IDs
MGD-MRK-14507, MGI:2142080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory