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Sox6 Gene Detail
Summary
  • Symbol
    Sox6
  • Name
    SRY (sex determining region Y)-box 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:98368
    NCBI Gene: 20679
  • Gene Overview
    MyGene.info: SOX6
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:115470872-116038796 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 61.29 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3810 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98368
protein coding gene Chr7:115470872-116041138 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032887
protein coding gene Chr7:119192787-119768549 (-)
A/J MGP_AJ_G0032870
protein coding gene Chr7:116183426-116751225 (-)
AKR/J MGP_AKRJ_G0032802
protein coding gene Chr7:119122260-119680861 (-)
BALB/cJ MGP_BALBcJ_G0032875
protein coding gene Chr7:115890604-116463247 (-)
C3H/HeJ MGP_C3HHeJ_G0032585
protein coding gene Chr7:119078726-119642521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033381
protein coding gene Chr7:123958946-124560942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030353
protein coding gene Chr7:117705046-118265068 (-)
CAST/EiJ MGP_CASTEiJ_G0031913
protein coding gene Chr7:110741670-111330369 (-)
CBA/J MGP_CBAJ_G0032558
protein coding gene Chr7:128087262-128685688 (-)
DBA/2J MGP_DBA2J_G0032710
protein coding gene Chr7:114250356-114808349 (-)
FVB/NJ MGP_FVBNJ_G0032663
protein coding gene Chr7:114087904-114648552 (-)
LP/J MGP_LPJ_G0032804
protein coding gene Chr7:120676875-121249977 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032695
protein coding gene Chr7:129663490-130272841 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033401
protein coding gene Chr7:118111510-118696506 (-)
PWK/PhJ MGP_PWKPhJ_G0031621
protein coding gene Chr7:107123330-107682406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031468
protein coding gene Chr7:104841414-105414148 (-)
WSB/EiJ MGP_WSBEiJ_G0032026
protein coding gene Chr7:118984170-119569585 (-)



Homology
more
  • Human Ortholog
    SOX6, SRY-box 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOX6, SRY-box 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSSOX6, SOXD
  • Links
    NCBI Gene ID: 55553
    neXtProt AC: NX_P35712
    UniProt: P35712

  • Chr Location
    11p15.2; chr11:15966449-16476388 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit cardioskeletal myopathy, cardiac blockage, delayed growth, and early postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051910 Ensembl Gene Model | MGI Sequence Detail 567925 C57BL/6J ±  kb
    transcript ENSMUST00000206369 Ensembl | MGI Sequence Detail 2863 Not Applicable  
    polypeptide ENSMUSP00000145931 Ensembl | MGI Sequence Detail 828 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 2
      cDNA 23
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14507, MGI:2142080
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 76
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:264124 Tsushima H, et al., Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory