Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cartilage development; positive regulation of chondrocyte differentiation; and spinal cord oligodendrocyte cell differentiation. Acts upstream of or within several processes, including erythrocyte development; oligodendrocyte cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; genitourinary system; limb; and nervous system. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6).