Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SORL1
  • Mouse genes Sorl1
  • Rat genes Sorl1
  • Zfish genes sorl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sorl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	SORL1	IPI	UniProtKB:P05067	Human	PMID:16407538
Molecular Function	GO:0001540	amyloid-beta binding	SORL1	IDA		Human	PMID:24523320
Molecular Function	GO:0030169	low-density lipoprotein particle binding	SORL1	IPI	UniProtKB:P02649	Human	PMID:17326667
Molecular Function	GO:0030169	low-density lipoprotein particle binding	SORL1	IPI	UniProtKB:Q6Q788	Human	PMID:17326667
Molecular Function	GO:0042923	neuropeptide binding	SORL1	IPI	UniProtKB:P69208	Human	PMID:11082041
Molecular Function	GO:0042923	neuropeptide binding	SORL1	IPI	UniProtKB:P30990	Human	PMID:11294867
Molecular Function	GO:0042923	neuropeptide binding	SORL1	IPI	UniProtKB:P69208	Human	PMID:11294867
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P30533	Human	PMID:11294867
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY4	Human	PMID:11821067
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY5	Human	PMID:11821067
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q03405	Human	PMID:14764453
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067	Human	PMID:16174740
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067-4	Human	PMID:16174740
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067-4	Human	PMID:16407538
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067:PRO_0000000091	Human	PMID:16407538
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P56817	Human	PMID:16407538
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P30533	Human	PMID:17326667
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q6VY07	Human	PMID:17855360
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P06858	Human	PMID:21385844
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P39905	Human	PMID:21994944
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P39905:PRO_0000034005	Human	PMID:23333276
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P56159-2	Human	PMID:23333276
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q62997	Human	PMID:23333276
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q92673:PRO_0000033164	Human	PMID:23333276
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q6VY07	Human	PMID:24001769
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:25643321
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY5	Human	PMID:26053850
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:O75462	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P26992	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P30533	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q92673:PRO_0000033164	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05231	Human	PMID:28265003
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P08887	Human	PMID:28265003
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q92673:PRO_0000033164	Human	PMID:28265003
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P30533	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P02649	Human	PMID:30448281
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:O43301	Human	PMID:30679749
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY4	Human	PMID:30679749
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY5	Human	PMID:30679749
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q15669	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P00491	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P19404	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P20042	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P43681	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:P83916	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q8N0S8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SORL1	IPI	UniProtKB:Q9UJY4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	UniProtKB:Q9EQH3	Mouse	MGI:MGI:3795652|PMID:18480253
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	UniProtKB:P12023	Mouse	MGI:MGI:5468380|PMID:23283322
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	UniProtKB:P36895|UniProtKB:P36898	Mouse	MGI:MGI:5704270|PMID:26584636
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	UniProtKB:P12023	Mouse	MGI:MGI:3611604|PMID:16407538
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	PR:P15208	Mouse	PMID:27322061
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	MGI:MGI:3584516	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	PR:A2ARV4	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	PR:Q91ZX7	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Sorl1	IPI	PR:Q8VI56	Mouse	PMID:19047013
Molecular Function	GO:0031267	small GTPase binding	SORL1	IPI	UniProtKB:Q9UJY5	Human	PMID:17855360
Molecular Function	GO:0004888	transmembrane signaling receptor activity	SORL1	IDA		Human	PMID:11294867
Cellular Component	GO:0009986	cell surface	SORL1	IDA		Human	PMID:11294867
Cellular Component	GO:0005769	early endosome	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0005769	early endosome	SORL1	IMP		Human	PMID:22621900
Cellular Component	GO:0005769	early endosome	SORL1	IDA		Human	PMID:24001769
Cellular Component	GO:0005783	endoplasmic reticulum	SORL1	IDA		Human	PMID:17855360
Cellular Component	GO:0005783	endoplasmic reticulum	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0005768	endosome	SORL1	IDA		Human	PMID:16174740
Cellular Component	GO:0005768	endosome	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0070062	extracellular exosome	SORL1	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	SORL1	IDA		Human	PMID:14764453
Cellular Component	GO:0005615	extracellular space	Sorl1	IDA		Mouse	MGI:MGI:6393363|PMID:11082041
Cellular Component	GO:0005794	Golgi apparatus	SORL1	IDA		Human	PMID:11294867
Cellular Component	GO:0005794	Golgi apparatus	SORL1	IDA		Human	PMID:16174740
Cellular Component	GO:0005794	Golgi apparatus	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0005794	Golgi apparatus	SORL1	IDA		Human	PMID:21994944
Cellular Component	GO:0031985	Golgi cisterna	SORL1	IDA		Human	PMID:17855360
Cellular Component	GO:0016020	membrane	SORL1	IDA		Human	PMID:14764453
Cellular Component	GO:0016020	membrane	Sorl1	IDA		Mouse	MGI:MGI:6393363|PMID:11082041
Cellular Component	GO:0005771	multivesicular body	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0005771	multivesicular body	Sorl1	IDA		Rat	PMID:16452683|RGD:1581100
Cellular Component	GO:0043025	neuronal cell body	Sorl1	IDA		Rat	PMID:10867025|RGD:1581103
Cellular Component	GO:0005641	nuclear envelope lumen	SORL1	IDA		Human	PMID:17855360
Cellular Component	GO:0005641	nuclear envelope lumen	SORL1	IDA		Human	PMID:21989385
Cellular Component	GO:0005641	nuclear envelope lumen	Sorl1	IDA		Mouse	MGI:MGI:3801250|PMID:18362153
Cellular Component	GO:0097356	perinucleolar compartment	Sorl1	IDA		Mouse	MGI:MGI:6393363|PMID:11082041
Cellular Component	GO:0005886	plasma membrane	SORL1	IDA		Human	PMID:21385844
Cellular Component	GO:0005886	plasma membrane	SORL1	IDA		Human	PMID:21994944
Cellular Component	GO:0055037	recycling endosome	SORL1	IMP		Human	PMID:22621900
Cellular Component	GO:0005802	trans-Golgi network	SORL1	IDA		Human	PMID:24001769
Biological Process	GO:1990845	adaptive thermogenesis	Sorl1	IMP		Mouse	MGI:MGI:5704270|PMID:26584636
Biological Process	GO:0016477	cell migration	Sorl1	IMP		Rat	PMID:11956127|RGD:1581101
Biological Process	GO:0008283	cell population proliferation	Sorl1	IEP		Rat	PMID:10964672|RGD:1581102
Biological Process	GO:0002024	diet induced thermogenesis	Sorl1	IMP		Mouse	MGI:MGI:5704270|PMID:26584636
Biological Process	GO:0099638	endosome to plasma membrane protein transport	Sorl1	IDA		Mouse	PMID:27322061
Biological Process	GO:0038020	insulin receptor recycling	SORL1	IDA		Human	PMID:27322061
Biological Process	GO:0038020	insulin receptor recycling	Sorl1	IDA		Mouse	PMID:27322061
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IDA		Human	PMID:16407538
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IMP		Human	PMID:17855360
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IMP		Human	PMID:21989385
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IDA		Human	PMID:22621900
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IMP		Human	PMID:24001769
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	SORL1	IMP		Human	PMID:24523320
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Sorl1	IMP		Mouse	MGI:MGI:3821635|PMID:19036982
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	SORL1	IDA		Human	PMID:16407538
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	SORL1	IMP		Human	PMID:17855360
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	SORL1	IMP		Human	PMID:21989385
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Sorl1	IMP		Mouse	MGI:MGI:5704270|PMID:26584636
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	SORL1	IMP		Human	PMID:17855360
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	SORL1	IMP		Human	PMID:21989385
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:1902997	negative regulation of neurofibrillary tangle assembly	Sorl1	IMP		Mouse	MGI:MGI:5569468|PMID:22986780
Biological Process	GO:0050768	negative regulation of neurogenesis	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:1901215	negative regulation of neuron death	Sorl1	IMP		Mouse	MGI:MGI:5569468|PMID:22986780
Biological Process	GO:0032091	negative regulation of protein binding	SORL1	IDA		Human	PMID:16407538
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	SORL1	IMP		Human	PMID:21989385
Biological Process	GO:1902948	negative regulation of tau-protein kinase activity	Sorl1	IMP		Mouse	MGI:MGI:5569468|PMID:22986780
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	Sorl1	IMP		Mouse	MGI:MGI:5811185|PMID:27322061
Biological Process	GO:0007218	neuropeptide signaling pathway	SORL1	IDA		Human	PMID:11294867
Biological Process	GO:1904179	positive regulation of adipose tissue development	SORL1	IDA		Human	PMID:27322061
Biological Process	GO:1904179	positive regulation of adipose tissue development	Sorl1	IMP		Mouse	MGI:MGI:5811185|PMID:27322061
Biological Process	GO:1902771	positive regulation of choline O-acetyltransferase activity	Sorl1	IMP		Mouse	MGI:MGI:5569468|PMID:22986780
Biological Process	GO:1902955	positive regulation of early endosome to recycling endosome transport	SORL1	IMP		Human	PMID:22621900
Biological Process	GO:2001137	positive regulation of endocytic recycling	SORL1	IMP		Human	PMID:22621900
Biological Process	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport	SORL1	IMP		Human	PMID:17855360
Biological Process	GO:1900168	positive regulation of glial cell-derived neurotrophic factor production	SORL1	IDA		Human	PMID:21994944
Biological Process	GO:1900168	positive regulation of glial cell-derived neurotrophic factor production	Sorl1	IMP		Mouse	MGI:MGI:6316588|PMID:21994944
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	SORL1	IDA		Human	PMID:27322061
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Sorl1	IMP		Mouse	MGI:MGI:5811185|PMID:27322061
Biological Process	GO:0045732	positive regulation of protein catabolic process	SORL1	IDA		Human	PMID:24523320
Biological Process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	SORL1	IMP		Human	PMID:17855360
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	SORL1	IMP		Human	PMID:22621900
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport	SORL1	IDA		Human	PMID:17855360
Biological Process	GO:0034067	protein localization to Golgi apparatus	SORL1	IDA		Human	PMID:17855360
Biological Process	GO:0051604	protein maturation	SORL1	IDA		Human	PMID:17855360
Biological Process	GO:0045053	protein retention in Golgi apparatus	SORL1	IDA		Human	PMID:17855360
Biological Process	GO:0045053	protein retention in Golgi apparatus	Sorl1	IMP		Mouse	MGI:MGI:3801250|PMID:18362153
Biological Process	GO:0006605	protein targeting	SORL1	IMP		Human	PMID:16174740
Biological Process	GO:0006605	protein targeting	SORL1	IDA		Human	PMID:16407538
Biological Process	GO:0006605	protein targeting	SORL1	IDA		Human	PMID:21385844
Biological Process	GO:0006605	protein targeting	SORL1	IDA		Human	PMID:27322061
Biological Process	GO:0006605	protein targeting	Sorl1	IDA		Mouse	MGI:MGI:5811185|PMID:27322061
Biological Process	GO:0006622	protein targeting to lysosome	SORL1	IDA		Human	PMID:24523320
Biological Process	GO:0006898	receptor-mediated endocytosis	SORL1	IDA		Human	PMID:11294867
Biological Process	GO:0014910	regulation of smooth muscle cell migration	SORL1	IDA		Human	PMID:14764453

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern