Sorl1
Gene Detail

Symbol Name ID

Sorl1 sortilin-related receptor, LDLR class A repeats-containing MGI:1202296

Synonyms

2900010L19Rik, LR11, mSorLA, Sorla

Feature Type

protein coding gene

Genetic Map

Chromosome 9

23.55 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:41964720-42124297 bp, - strand From VEGA annotation of GRCm38   159578 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Sorl1 ± 2 cM)

Gene Tree: Sorl1

Human ortholog

SORL1 sortilin-related receptor, L(DLR class) A repeats containing NCBI Gene ID 6653
Human Synonyms: C11orf32, gp250, LR11, LRP9, SORLA, SorLA-1
Human Chr11:121322961-121504471 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SORL1 (1)

Alleles and phenotypes

All alleles(17) : Targeted(4) Gene trapped(13)
 

Homozygous mutation of this gene results in decreased femoral artery intimal thickness after cuff placement and abolished angiotensin II stimulated vascular smooth muscle migration and attachment. Two other alleles show an increase in beta-amyloid deposits or peptide in the brain.

 
Human Diseases Modeled Using Mouse Sorl1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cholesterol metabolic process, endocytosis, ...
Component	integral to membrane, low-density lipoprotein particle, ...
Function	low-density lipoprotein particle binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (226)    Tissues (28)    Images (24)
Theiler Stages: 23, 24, 26

Assay Type	Results
RNA in situ	226

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(2) cDNA(25) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000031794 (Evidence)
Ensembl Gene Model	ENSMUSG00000049313 (Evidence)
Entrez Gene	20660 (Evidence)
DFCI	TC1601394
DoTS	DT.482918, DT.97386360
NIA Mouse Gene Index	U030748
Consensus CDS Project	CCDS40594.1
International Mouse Knockout Project Status	Sorl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031794	VEGA Gene Model | MGI Sequence Detail	159578	C57BL/6J
transcript	OTTMUST00000078792	VEGA | MGI Sequence Detail	10715	Not Applicable
polypeptide	OTTMUSP00000041931	VEGA | MGI Sequence Detail	2215	Not Applicable

All sequences(43) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(1022 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
InterPro	IPR006581	VPS10
Protein Ontology	PR:000015411	sortilin-related receptor

References

(Earliest) J:46143 Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
(Latest) J:193915 Carlo AS, et al., The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain. J Neurosci. 2013 Jan 2;33(1):358-70
All references(60)

Other accession IDs

MGI:1920160, MGI:2143102, MGI:2143305