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Gene Detail
sortilin-related receptor, LDLR class A repeats-containing
Synonyms 2900010L19Rik, LR11, mSorLA, Sorla
Feature Type protein coding gene
Genetic Map
Chromosome 9
23.55 cM, cytoband B
Detailed Genetic Map ± 1 cM

Mapping data(5)
Sequence Map
Chr9:41964720-42124297 bp, - strand
From VEGA annotation of GRCm38

  159578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:2336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sorl1

Human Homolog SORL1, sortilin-related receptor, L(DLR class) A repeats containing
NCBI Gene ID 6653
neXtProt AC  NX_Q92673
Human Synonyms  C11orf32, gp250, LR11, LRP9, SORLA, SorLA-1
Human Chr (Location)  11q23.2-q24.2; chr11:121452203-121633762 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SORL1
alleles, and
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutation of this gene results in decreased femoral artery intimal thickness after cuff placement and abolished angiotensin II stimulated vascular smooth muscle migration and attachment. Two other alleles show an increase in beta-amyloid deposits or peptide in the brain.
Alleles Annotated to Human Diseases(1)   
Sorl1 interacts with 453 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (48 annotations)
Process cell migration, cholesterol metabolic process, ...
Component early endosome, endoplasmic reticulum, ...
Function ADP-ribosylation factor binding, beta-amyloid binding, ...
External Resources: FuncBase
Literature Summary: (11 records)
Data Summary: Results (370)    Tissues (152)    Images (73)
Theiler Stages: 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 360
Northern blot 10
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(30) Genomic(2) cDNA(26) Primer pair(2)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000031794 (Evidence)
Ensembl Gene ModelENSMUSG00000049313 (Evidence)
Entrez Gene20660 (Evidence)
DoTSDT.482918, DT.97386360
NIA Mouse Gene IndexU030748
Consensus CDS ProjectCCDS40594.1
International Mouse Knockout Project StatusSorl1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031794 VEGA Gene Model | MGI Sequence Detail 159578 C57BL/6J ±  kb
transcript OTTMUST00000078792 VEGA | MGI Sequence Detail 10715 Not Applicable 
polypeptide OTTMUSP00000041931 VEGA | MGI Sequence Detail 2215 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(2417 from dbSNP Build 137)
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR006581 VPS10
Protein Ontology PR:000015411 sortilin-related receptor
References (Earliest) J:46143 Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
(Latest) J:210074 Capsoni S, et al., SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33(2):357-71
All references(68)
accession IDs
MGI:1920160, MGI:2143102, MGI:2143305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory