About   Help   FAQ
Sorl1 Gene Detail
Summary
  • Symbol
    Sorl1
  • Name
    sortilin-related receptor, LDLR class A repeats-containing
  • Synonyms
    2900010L19Rik, LR11, mSorLA, Sorla
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202296
    NCBI Gene: 20660
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:41964718-42124289 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 23.55 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2369 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202296
protein coding gene Chr9:41964718-42124297 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034675
protein coding gene Chr9:40284331-40456092 (-)
A/J MGP_AJ_G0034655
protein coding gene Chr9:39221974-39381455 (-)
AKR/J MGP_AKRJ_G0034581
protein coding gene Chr9:39973624-40147716 (-)
BALB/cJ MGP_BALBcJ_G0034646
protein coding gene Chr9:38953412-39112986 (-)
C3H/HeJ MGP_C3HHeJ_G0034357
protein coding gene Chr9:40485172-40645280 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035169
protein coding gene Chr9:41552536-41717185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032082
protein coding gene Chr9:38833633-38989547 (-)
CAST/EiJ MGP_CASTEiJ_G0033680
protein coding gene Chr9:40265411-40438759 (-)
CBA/J MGP_CBAJ_G0034330
protein coding gene Chr9:43018567-43195799 (-)
DBA/2J MGP_DBA2J_G0034489
protein coding gene Chr9:39143937-39306233 (-)
FVB/NJ MGP_FVBNJ_G0034429
protein coding gene Chr9:38373539-38532320 (-)
LP/J MGP_LPJ_G0034570
protein coding gene Chr9:40559572-40725538 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034473
protein coding gene Chr9:45006833-45172798 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035188
protein coding gene Chr9:39892987-40056321 (-)
PWK/PhJ MGP_PWKPhJ_G0033385
protein coding gene Chr9:38967750-39129797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033221
protein coding gene Chr9:40138074-40306270 (-)
WSB/EiJ MGP_WSBEiJ_G0033793
protein coding gene Chr9:39926882-40093880 (-)



Homology
more
  • Human Ortholog
    SORL1, sortilin related receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SORL1, sortilin related receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C11orf32, gp250, LR11, LRP9, SORLA, SorLA-1
  • Links
    NCBI Gene ID: 6653
    neXtProt AC: NX_Q92673
    UniProt: Q92673

  • Chr Location
    11q24.1; chr11:121452203-121633762 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2336
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SORL1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased femoral artery intimal thickness after cuff placement and abolished angiotensin II stimulated vascular smooth muscle migration and attachment. Two other alleles show an increase in beta-amyloid deposits or peptide in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20660 NCBI Gene Model | MGI Sequence Detail 159572 C57BL/6J ±  kb
    transcript NM_011436 RefSeq | MGI Sequence Detail 10726 C57BL/6  
    polypeptide O88307 UniProt | EBI | MGI Sequence Detail 2215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 27
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920160, MGI:2143102, MGI:2143305
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:46143 Hermans-Borgmeyer I, et al., Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev. 1998 Jan;70(1-2):65-76
    • Latest
      J:262637 Hojland A, et al., Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner. Behav Brain Res. 2018 Aug 1;348:90-100

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory