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Gene Ontology Browser
Term Detail
GO term:transmembrane signaling receptor activity
Synonym: non G protein coupled 7TM receptor activity
Synonym: non-G-protein coupled 7TM receptor activity
Synonym: non-G-protein-coupled 7TM receptor activity
Synonym: transmembrane receptor activity
Synonym: transmembrane signalling receptor activity
GO id:GO:0004888
Definition:Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Comments'Transmembrane' in the term name refers to the mechanism of transmitting the signal across the membrane, rather than the subcellular location of the receptor.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-aadvanced glycation end-product receptor activity
                                        is-aaryl hydrocarbon receptor activity
                                        is-aauxin receptor activity
                                        is-abile acid receptor activity +
                                        is-acalcitriol receptor activity
                                        is-acoreceptor activity +
                                        is-adiuretic hormone receptor activity
                                        is-aethylene receptor activity +
                                        is-ahigh molecular weight B cell growth factor receptor activity
                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                        is-ajuvenile hormone receptor activity
                                        is-aleucokinin receptor activity
                                        is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                        is-aneurotransmitter receptor activity +
                                        is-aneurotrophin receptor activity +
                                        is-apeptide receptor activity +
                                        is-aphorbol ester receptor activity +
                                        is-aphosphorelay sensor kinase activity
                                        is-aphotoreceptor activity +
                                        is-aretinoic acid receptor activity +
                                        is-asignaling pattern recognition receptor activity +
                                        is-asteroid hormone receptor activity +
                                        is-athrombospondin receptor activity
                                        is-athyroid hormone receptor activity
                                        is-atransmembrane signaling receptor activity [GO:0004888] (2130 genes, 4097 annotations)
                                                is-aacetylcholine receptor activity +
                                                is-aapolipoprotein A-I receptor activity
                                                is-aaxon guidance receptor activity
                                                is-acollagen receptor activity +
                                                is-acomplement receptor activity +
                                                is-acytokine receptor activity +
                                                is-acytokinin receptor activity +
                                                is-adeath receptor activity +
                                                is-aG-protein coupled receptor activity +
                                                is-aGABA receptor activity +
                                                is-aglutamate receptor activity +
                                                is-ahedgehog receptor activity
                                                is-aICAM-3 receptor activity
                                                is-aimmunoglobulin receptor activity +
                                                is-alatrotoxin receptor activity
                                                is-aMHC class I receptor activity +
                                                is-aMHC class Ib receptor activity
                                                is-aMHC class II receptor activity
                                                is-anetrin receptor activity +
                                                is-aneuregulin receptor activity
                                                is-aneurotensin receptor activity, non-G-protein coupled
                                                is-anon-tyrosine kinase fibroblast growth factor receptor activity
                                                is-anucleotide receptor activity +
                                                is-aolfactory receptor activity +
                                                is-aopsonin receptor activity +
                                                is-aosmosensor activity
                                                is-apurinergic receptor activity +
                                                is-areelin receptor activity
                                                is-asemaphorin receptor activity
                                                is-asulfonylurea receptor activity
                                                is-atiggrin receptor activity
                                                is-atransmembrane receptor protein kinase activity +
                                                is-atransmembrane receptor protein phosphatase activity +
                                                is-aWnt-activated receptor activity
                                        is-aurokinase plasminogen activator receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-aadvanced glycation end-product receptor activity
                                is-aaryl hydrocarbon receptor activity
                                is-aauxin receptor activity
                                is-abile acid receptor activity +
                                is-acalcitriol receptor activity
                                is-acoreceptor activity +
                                is-adiuretic hormone receptor activity
                                is-aethylene receptor activity +
                                is-ahigh molecular weight B cell growth factor receptor activity
                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                is-ajuvenile hormone receptor activity
                                is-aleucokinin receptor activity
                                is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                is-aneurotransmitter receptor activity +
                                is-aneurotrophin receptor activity +
                                is-apeptide receptor activity +
                                is-aphorbol ester receptor activity +
                                is-aphosphorelay sensor kinase activity
                                is-aphotoreceptor activity +
                                is-aretinoic acid receptor activity +
                                is-asignaling pattern recognition receptor activity +
                                is-asteroid hormone receptor activity +
                                is-athrombospondin receptor activity
                                is-athyroid hormone receptor activity
                                is-atransmembrane signaling receptor activity [GO:0004888] (2130 genes, 4097 annotations)
                                        is-aacetylcholine receptor activity +
                                        is-aapolipoprotein A-I receptor activity
                                        is-aaxon guidance receptor activity
                                        is-acollagen receptor activity +
                                        is-acomplement receptor activity +
                                        is-acytokine receptor activity +
                                        is-acytokinin receptor activity +
                                        is-adeath receptor activity +
                                        is-aG-protein coupled receptor activity +
                                        is-aGABA receptor activity +
                                        is-aglutamate receptor activity +
                                        is-ahedgehog receptor activity
                                        is-aICAM-3 receptor activity
                                        is-aimmunoglobulin receptor activity +
                                        is-alatrotoxin receptor activity
                                        is-aMHC class I receptor activity +
                                        is-aMHC class Ib receptor activity
                                        is-aMHC class II receptor activity
                                        is-anetrin receptor activity +
                                        is-aneuregulin receptor activity
                                        is-aneurotensin receptor activity, non-G-protein coupled
                                        is-anon-tyrosine kinase fibroblast growth factor receptor activity
                                        is-anucleotide receptor activity +
                                        is-aolfactory receptor activity +
                                        is-aopsonin receptor activity +
                                        is-aosmosensor activity
                                        is-apurinergic receptor activity +
                                        is-areelin receptor activity
                                        is-asemaphorin receptor activity
                                        is-asulfonylurea receptor activity
                                        is-atiggrin receptor activity
                                        is-atransmembrane receptor protein kinase activity +
                                        is-atransmembrane receptor protein phosphatase activity +
                                        is-aWnt-activated receptor activity
                                is-aurokinase plasminogen activator receptor activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory