Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIX4
  • Mouse genes Six4
  • Rat genes Six4
  • Zfish genes six4a,six4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Six4	IDA		Mouse	PMID:14966291
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Six4	IDA		Mouse	MGI:MGI:3608315|PMID:15955062
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Six4	IDA		Mouse	PMID:14966291
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Six4	IDA		Mouse	PMID:15955062
Molecular Function	GO:0005515	protein binding	Six4	IPI	UniProtKB:O70546	Mouse	MGI:MGI:5508570|PMID:20300060
Molecular Function	GO:0005515	protein binding	Six4	IPI	UniProtKB:P97480	Mouse	MGI:MGI:5582180|PMID:12215533
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Six4	IDA		Mouse	MGI:MGI:3608315|PMID:15955062
Molecular Function	GO:0043565	sequence-specific DNA binding	Six4	IDA		Mouse	PMID:8814301
Molecular Function	GO:0043565	sequence-specific DNA binding	Six4	IDA		Mouse	PMID:9826681
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SIX4	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Six4	IDA		Mouse	MGI:MGI:1330660|PMID:9990334
Cellular Component	GO:0005634	nucleus	Six4	IDA		Mouse	MGI:MGI:1330660|PMID:9990334
Cellular Component	GO:0005634	nucleus	Six4	IDA		Mouse	PMID:9826681
Cellular Component	GO:0005634	nucleus	Six4	IDA		Mouse	PMID:8814301
Biological Process	GO:0048856	anatomical structure development	Six4	IGI	MGI:MGI:102780	Mouse	PMID:16530750
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Six4	IGI	MGI:MGI:102780	Mouse	PMID:20515681
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Six4	IGI	MGI:MGI:102780	Mouse	PMID:15788460
Biological Process	GO:0061197	fungiform papilla morphogenesis	Six4	IMP		Mouse	MGI:MGI:5448822|PMID:21978088
Biological Process	GO:0048699	generation of neurons	Six4	IMP		Mouse	MGI:MGI:3689152|PMID:16938278
Biological Process	GO:0042472	inner ear morphogenesis	Six4	IGI	MGI:MGI:102780	Mouse	PMID:15788460
Biological Process	GO:0008584	male gonad development	Six4	IMP		Mouse	MGI:MGI:5532793|PMID:23987514
Biological Process	GO:0030238	male sex determination	Six4	IMP		Mouse	MGI:MGI:5532793|PMID:23987514
Biological Process	GO:0046661	male sex differentiation	Six4	IMP		Mouse	MGI:MGI:5532793|PMID:23987514
Biological Process	GO:0072075	metanephric mesenchyme development	Six4	IMP		Mouse	MGI:MGI:5009396|PMID:17300925
Biological Process	GO:0051451	myoblast migration	Six4	IGI	MGI:MGI:102780	Mouse	PMID:15788460
Biological Process	GO:0061055	myotome development	Six4	IMP		Mouse	MGI:MGI:4421263|PMID:19962975
Biological Process	GO:0061055	myotome development	Six4	IMP		Mouse	MGI:MGI:3578604|PMID:15788460
Biological Process	GO:0043066	negative regulation of apoptotic process	Six4	IMP		Mouse	MGI:MGI:3578604|PMID:15788460
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six4	IDA		Mouse	MGI:MGI:3608315|PMID:15955062
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six4	IDA		Mouse	MGI:MGI:4836102|PMID:20696153
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Six4	IMP		Mouse	MGI:MGI:3689152|PMID:16938278
Biological Process	GO:1902725	negative regulation of satellite cell differentiation	Six4	IMP		Mouse	MGI:MGI:4836102|PMID:20696153
Biological Process	GO:0030910	olfactory placode formation	Six4	IMP		Mouse	MGI:MGI:3833798|PMID:19027001
Biological Process	GO:0060037	pharyngeal system development	Six4	IMP		Mouse	MGI:MGI:3624596|PMID:16530750
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Six4	IMP		Mouse	MGI:MGI:5009396|PMID:17300925
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IDA		Mouse	MGI:MGI:3608315|PMID:15955062
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IMP		Mouse	MGI:MGI:5009396|PMID:17300925
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IDA		Mouse	MGI:MGI:4421263|PMID:19962975
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IMP		Mouse	MGI:MGI:3715562|PMID:17592144
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IMP		Mouse	MGI:MGI:5532793|PMID:23987514
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Six4	IDA		Mouse	PMID:14966291
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Six4	IDA		Mouse	PMID:15955062
Biological Process	GO:0072107	positive regulation of ureteric bud formation	Six4	IMP		Mouse	MGI:MGI:5009396|PMID:17300925
Biological Process	GO:0034504	protein localization to nucleus	Six4	IDA		Mouse	MGI:MGI:3687674|PMID:10490620
Biological Process	GO:0072095	regulation of branch elongation involved in ureteric bud branching	Six4	IMP		Mouse	MGI:MGI:5009396|PMID:17300925
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Six4	IMP		Mouse	MGI:MGI:3833798|PMID:19027001
Biological Process	GO:0010468	regulation of gene expression	Six4	IGI	MGI:MGI:102780	Mouse	PMID:21884692
Biological Process	GO:0032880	regulation of protein localization	Six4	IGI	MGI:MGI:102780	Mouse	PMID:21884692
Biological Process	GO:0008582	regulation of synaptic assembly at neuromuscular junction	Six4	IGI	MGI:MGI:102780	Mouse	PMID:21884692
Biological Process	GO:0045214	sarcomere organization	Six4	IMP		Mouse	MGI:MGI:5298278|PMID:21884692
Biological Process	GO:0098528	skeletal muscle fiber differentiation	Six4	IMP		Mouse	MGI:MGI:5298278|PMID:21884692
Biological Process	GO:0007519	skeletal muscle tissue development	Six4	IMP		Mouse	MGI:MGI:3715562|PMID:17592144
Biological Process	GO:0007519	skeletal muscle tissue development	Six4	IGI	MGI:MGI:102780	Mouse	PMID:15788460
Biological Process	GO:0048538	thymus development	Six4	IGI	MGI:MGI:102780	Mouse	PMID:16530750
Biological Process	GO:0043586	tongue development	Six4	IMP		Mouse	MGI:MGI:5448822|PMID:21978088
Biological Process	GO:0061551	trigeminal ganglion development	Six4	IMP		Mouse	MGI:MGI:3689152|PMID:16938278

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern