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Six4
Gene Detail
 Symbol
Name
ID
Six4
sine oculis-related homeobox 4
MGI:106034
Synonyms AREC3, TrexBF
Feature Type protein coding gene
Genetic Map
Chromosome 12
30.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:73099609-73113456 bp, - strand
From VEGA annotation of GRCm38

  13848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Six4

Human
homologs
Human Homolog SIX4, SIX homeobox 4
NCBI Gene ID 51804
neXtProt AC  NX_Q9UIU6
Human Synonyms  AREC3
Human Chr (Location)  14q23; chr14:60709538-60724321 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.
 
Interactions
Six4 interacts with 424 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process anatomical structure development, embryonic cranial skeleton morphogenesis, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (165)    Tissues (160)    Images (11)
Theiler Stages: 2, 3, 4, 5, 17, 18, 21, 22, 23, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 154
RT-PCR 8
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000040060 (Evidence)
Ensembl Gene ModelENSMUSG00000034460 (Evidence)
Entrez Gene20474 (Evidence)
UniGene249575
DFCITC1597798, TC1620493, TC1660733, TC1700017
DoTSDT.101368983, DT.55166164, DT.55188009
NIA Mouse Gene IndexU034064
Consensus CDS ProjectCCDS25974.1
International Mouse Knockout Project StatusSix4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040060 VEGA Gene Model | MGI Sequence Detail 13848 C57BL/6J ±  kb
transcript OTTMUST00000104021 VEGA | MGI Sequence Detail 6402 Not Applicable 
polypeptide OTTMUSP00000058167 VEGA | MGI Sequence Detail 775 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014899 homeobox protein SIX4
References (Earliest) J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
(Latest) J:206594 Daou N, et al., A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
All references(68)
Other
accession IDs
MGD-MRK-33718, MGI:2144757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory