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Six4
Gene Detail
Symbol

Name
ID
Six4
sine oculis-related homeobox 4
MGI:106034
Synonyms
AREC3, TrexBF
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:73099609-73113456 bp, - strand
From VEGA annotation of GRCm38

  13848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SIX4
Gene Tree: Six4

Human
homologs
SIX4, SIX homeobox 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51804
neXtProt AC: NX_Q9UIU6

Human Synonyms: AREC3

Human Chr (Location): 14q23; chr14:60709538-60724321 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.
 
Interactions
Six4 interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process anatomical structure development, embryonic cranial skeleton morphogenesis, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (165)    Tissues (160)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 154
RT-PCR 8
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase six4 ; ZFIN six4a, six4b    NEW 
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000040060 (Evidence)
Ensembl Gene Model ENSMUSG00000034460 (Evidence)
Entrez Gene 20474 (Evidence)
UniGene 249575
DFCI TC1620493, TC1597798, TC1700017, TC1660733
DoTS DT.101368983, DT.55188009, DT.55166164
NIA Mouse Gene Index U034064
Consensus CDS Project CCDS25974.1
International Mouse Phenotyping Consortium Status Six4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040060 VEGA Gene Model | MGI Sequence Detail 13848 C57BL/6J ±  kb
transcript OTTMUST00000104021 VEGA | MGI Sequence Detail 6402 Not Applicable 
polypeptide OTTMUSP00000058167 VEGA | MGI Sequence Detail 775 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014899 homeobox protein SIX4
References
(Earliest) J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
(Latest) J:206594 Daou N, et al., A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
All references(69)
Other
accession IDs
MGD-MRK-33718, MGI:2144757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory