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Six4 Gene Detail
Summary
  • Symbol
    Six4
  • Name
    sine oculis-related homeobox 4
  • Synonyms
    AREC3, TrexBF
  • Feature Type
    protein coding gene
  • IDs
    MGI:106034
    NCBI Gene: 20474
  • Gene Overview
    MyGene.info: SIX4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:73099609-73113456 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106034
protein coding gene Chr12:73099609-73114770 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019833
protein coding gene Chr12:72974619-72988461 (-)
A/J MGP_AJ_G0019791
protein coding gene Chr12:70256582-70270627 (-)
AKR/J MGP_AKRJ_G0019766
protein coding gene Chr12:72381836-72395683 (-)
BALB/cJ MGP_BALBcJ_G0019771
protein coding gene Chr12:70733920-70747794 (-)
C3H/HeJ MGP_C3HHeJ_G0019576
protein coding gene Chr12:72808389-72822263 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020223
protein coding gene Chr12:75252859-75266706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017841
protein coding gene Chr12:67707021-67720750 (-)
CAST/EiJ MGP_CASTEiJ_G0019128
protein coding gene Chr12:67603186-67617589 (-)
CBA/J MGP_CBAJ_G0019546
protein coding gene Chr12:78107707-78121776 (-)
DBA/2J MGP_DBA2J_G0019662
protein coding gene Chr12:70147376-70161223 (-)
FVB/NJ MGP_FVBNJ_G0019649
protein coding gene Chr12:68999963-69013827 (-)
LP/J MGP_LPJ_G0019734
protein coding gene Chr12:73012006-73025846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019688
protein coding gene Chr12:81262738-81276570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020258
protein coding gene Chr12:71866594-71880441 (-)
PWK/PhJ MGP_PWKPhJ_G0018893
protein coding gene Chr12:64456834-64470948 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018688
protein coding gene Chr12:66265406-66288198 (-)
WSB/EiJ MGP_WSBEiJ_G0019179
protein coding gene Chr12:72456789-72470693 (-)



Homology
more
  • Human Ortholog
    SIX4, SIX homeobox 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIX4, SIX homeobox 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AREC3
  • Links
    NCBI Gene ID: 51804
    neXtProt AC: NX_Q9UIU6
    UniProt: Q9UIU6

  • Chr Location
    14q23.1; chr14:60709538-60724321 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69089
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIX4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    33 phenotypes from multigenic genotypes
    23 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    2
  • Genomic Mutations
    1 involving Six4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034460 Ensembl Gene Model | MGI Sequence Detail 13848 C57BL/6J ±  kb
transcript ENSMUST00000043208 Ensembl | MGI Sequence Detail 6402 Not Applicable  
polypeptide ENSMUSP00000036150 Ensembl | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 41
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33718, MGI:2144757
References
more
  • Summaries
    All 79
    Developmental Gene Expression 32
    Gene Ontology 24
    Phenotypes 23
  • Earliest
    J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
  • Latest
    J:264162 Kaucka M, et al., Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. Elife. 2018 Jun 13;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory