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Six4 Gene Detail
Summary
  • Symbol
    Six4
  • Name
    sine oculis-related homeobox 4
  • Synonyms
    AREC3, TrexBF
  • Feature Type
    protein coding gene
  • IDs
    MGI:106034
    NCBI Gene: 20474
  • Gene Overview
    MyGene.info: SIX4
Location & Maps
more
  • Sequence Map
    Chr12:73099609-73113456 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13848 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SIX4, SIX homeobox 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIX4, SIX homeobox 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AREC3
  • Links
    NCBI Gene ID: 51804
    neXtProt AC: NX_Q9UIU6

  • Chr Location
    14q23; chr14:60709538-60724321 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69089
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: SIX4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    22 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    2
  • Genomic Mutations
    1 involving Six4
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040060 VEGA Gene Model | MGI Sequence Detail 13848 C57BL/6J ±  kb
transcript OTTMUST00000104021 VEGA | MGI Sequence Detail 6402 Not Applicable  
polypeptide OTTMUSP00000058167 VEGA | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 40
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-33718, MGI:2144757
References
more
  • Summaries
    All 68
    Developmental Gene Expression 27
    Gene Ontology 22
    Phenotypes 22
  • Earliest
    J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
  • Latest
    J:223386 Gomez-Marin C, et al., Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7542-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory