Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPTOR
  • Mouse genes Rptor
  • Rat genes Rptor
  • Zfish genes rptor
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rptor

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	RPTOR	IDA		Human	PMID:18439900
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:12150925
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P23443	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P67999	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q13541	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9JLN9	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:12408816
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9BVC4	Human	PMID:12408816
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q96B36	Human	PMID:17386266
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:17461779
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:17565979
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q8TCU6	Human	PMID:17565979
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q13541	Human	PMID:18337751
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:18955708
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:19446321
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:19619545
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:19875983
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P70445	Human	PMID:20347422
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q8WUA4	Human	PMID:20543138
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9BVC4	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:21045808
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q8TCU6	Human	PMID:21339740
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q96EB6	Human	PMID:21471201
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:21614075
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:22424946
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9P2J5	Human	PMID:22424946
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P50406	Human	PMID:23027611
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:23263282
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:23953116
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q13283	Human	PMID:23953116
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q96R06	Human	PMID:23953116
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345,UniProtKB:Q9NWS0,UniProtKB:Q9Y4R8	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9BVC4	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9JLN9	Human	PMID:24036451
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:24375676
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:25446900
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P62820	Human	PMID:25446900
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q6PJG6	Human	PMID:25657994
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:O75385	Human	PMID:25686248
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q6PKG0	Human	PMID:25940091
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:26348909
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:26678875
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q13615	Human	PMID:26787466
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P42345	Human	PMID:27043084
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:P45983	Human	PMID:27043084
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9Y2K2	Human	PMID:30232230
Molecular Function	GO:0005515	protein binding	RPTOR	IPI	UniProtKB:Q9NVC3	Human	PMID:35561222
Molecular Function	GO:0005515	protein binding	Rptor	IPI	UniProtKB:Q9JLN9	Mouse	MGI:MGI:3810855|PMID:18664580
Molecular Function	GO:0005515	protein binding	Rptor	IPI	UniProtKB:Q00899	Mouse	MGI:MGI:3767379|PMID:18046414
Molecular Function	GO:0005515	protein binding	Rptor	IPI	UniProtKB:Q9JLN9	Mouse	MGI:MGI:4867369|PMID:21045808
Molecular Function	GO:0005515	protein binding	Rptor	IPI	UniProtKB:Q9JLN9	Mouse	MGI:MGI:5514440|PMID:23966835
Molecular Function	GO:0005515	protein binding	Rptor	IPI	UniProtKB:Q9JLN9	Mouse	MGI:MGI:4830417|PMID:20801936
Molecular Function	GO:0030295	protein kinase activator activity	RPTOR	IDA		Human	PMID:12150926
Molecular Function	GO:0019901	protein kinase binding	RPTOR	IPI	UniProtKB:P54646	Human	PMID:18439900
Molecular Function	GO:0019901	protein kinase binding	RPTOR	IPI	UniProtKB:Q13131	Human	PMID:18439900
Molecular Function	GO:0019901	protein kinase binding	Rptor	IPI	RGD:68371	Rat	PMID:15525761|RGD:2307416
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	RPTOR	IDA		Human	PMID:12718876
Molecular Function	GO:0044877	protein-containing complex binding	RPTOR	IPI	UniProtKB:O75385	Human	PMID:19211835
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	RPTOR	IDA		Human	PMID:12150926
Molecular Function	GO:0001002	RNA polymerase III type 1 promoter sequence-specific DNA binding	RPTOR	IDA		Human	PMID:20233713
Molecular Function	GO:0001003	RNA polymerase III type 2 promoter sequence-specific DNA binding	RPTOR	IDA		Human	PMID:20233713
Molecular Function	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	RPTOR	IDA		Human	PMID:20233713
Molecular Function	GO:0001156	TFIIIC-class transcription factor complex binding	RPTOR	IDA		Human	PMID:20543138
Cellular Component	GO:0005737	cytoplasm	RPTOR	IDA		Human	PMID:20381137
Cellular Component	GO:0010494	cytoplasmic stress granule	RPTOR	IDA		Human	PMID:25940091
Cellular Component	GO:0005829	cytosol	RPTOR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Rptor	IDA		Rat	PMID:15525761|RGD:2307416
Cellular Component	GO:0005765	lysosomal membrane	RPTOR	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	RPTOR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	RPTOR	IDA		Human	PMID:20381137
Cellular Component	GO:0005764	lysosome	RPTOR	IMP		Human	PMID:22424946
Cellular Component	GO:0043025	neuronal cell body	Rptor	IDA		Rat	PMID:15525761|RGD:2307416
Cellular Component	GO:0005654	nucleoplasm	RPTOR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IPI		Human	PMID:26678875
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IDA		Human	PMID:12150926
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IDA		Human	PMID:12718876
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IDA		Human	PMID:15467718
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IDA		Human	PMID:24036451
Cellular Component	GO:0031931	TORC1 complex	RPTOR	IDA		Human	PMID:25940091
Biological Process	GO:0071230	cellular response to amino acid stimulus	RPTOR	IMP		Human	PMID:20381137
Biological Process	GO:0071233	cellular response to leucine	RPTOR	IDA		Human	PMID:22424946
Biological Process	GO:0031669	cellular response to nutrient levels	RPTOR	IMP		Human	PMID:12150925
Biological Process	GO:0046676	negative regulation of insulin secretion	Rptor	IMP		Mouse	MGI:MGI:5619445|PMID:23092880
Biological Process	GO:0016310	phosphorylation	RPTOR	IDA		Human	PMID:19299511
Biological Process	GO:0030307	positive regulation of cell growth	RPTOR	IMP		Human	PMID:18426977
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Rptor	IMP		Rat	PMID:17110594|RGD:2307383
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	RPTOR	IMP		Human	PMID:18426977
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	RPTOR	IMP		Human	PMID:18426977
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	RPTOR	IMP		Human	PMID:18426977
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	RPTOR	IDA		Human	PMID:12150926
Biological Process	GO:0032008	positive regulation of TOR signaling	RPTOR	IDA		Human	PMID:12150926
Biological Process	GO:0032008	positive regulation of TOR signaling	RPTOR	IDA		Human	PMID:18439900
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	RPTOR	IMP		Human	PMID:20233713
Biological Process	GO:0001558	regulation of cell growth	RPTOR	IMP		Human	PMID:20381137
Biological Process	GO:0008361	regulation of cell size	RPTOR	IMP		Human	PMID:12150925
Biological Process	GO:0042325	regulation of phosphorylation	Rptor	IMP		Rat	PMID:17110594|RGD:2307383
Biological Process	GO:0001932	regulation of protein phosphorylation	Rptor	IMP		Mouse	MGI:MGI:5619445|PMID:23092880
Biological Process	GO:0009410	response to xenobiotic stimulus	Rptor	IMP		Mouse	MGI:MGI:6506148|PMID:33495318
Biological Process	GO:0035176	social behavior	Rptor	IMP		Mouse	MGI:MGI:6506148|PMID:33495318
Biological Process	GO:0031929	TOR signaling	RPTOR	IDA		Human	PMID:20381137
Biological Process	GO:0038202	TORC1 signaling	RPTOR	IMP		Human	PMID:12718876

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern