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Rptor Gene Detail
Summary
  • Symbol
    Rptor
  • Name
    regulatory associated protein of MTOR, complex 1
  • Synonyms
    4932417H02Rik, mKIAA1303, Rap, raptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921620
    NCBI Gene: 74370
  • Gene Overview
    MyGene.info: RPTOR
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119602905-119899576 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    749 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921620
protein coding gene Chr11:119602905-119899591 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019485
protein coding gene Chr11:124020426-124320593 (+)
A/J MGP_AJ_G0019453
protein coding gene Chr11:118506482-118801314 (+)
AKR/J MGP_AKRJ_G0019423
protein coding gene Chr11:122075121-122379007 (+)
BALB/cJ MGP_BALBcJ_G0019428
protein coding gene Chr11:118864754-119157240 (+)
C3H/HeJ MGP_C3HHeJ_G0019234
protein coding gene Chr11:122403174-122698627 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019877
protein coding gene Chr11:127792236-128092607 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017502
protein coding gene Chr11:115504819-115804533 (+)
CAST/EiJ MGP_CASTEiJ_G0018788
protein coding gene Chr11:123876140-124175914 (+)
CBA/J MGP_CBAJ_G0019205
protein coding gene Chr11:132787794-133098681 (+)
DBA/2J MGP_DBA2J_G0019317
protein coding gene Chr11:117877089-118168038 (+)
FVB/NJ MGP_FVBNJ_G0019309
protein coding gene Chr11:117556071-117851864 (+)
LP/J MGP_LPJ_G0019389
protein coding gene Chr11:124337899-124635699 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019342
protein coding gene Chr11:131664758-131976040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019916
protein coding gene Chr11:122755478-123057522 (+)
PWK/PhJ MGP_PWKPhJ_G0018554
protein coding gene Chr11:119289343-119592917 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018346
protein coding gene Chr11:122520229-122826880 (+)
WSB/EiJ MGP_WSBEiJ_G0018840
protein coding gene Chr11:122746543-123049342 (+)



Homology
more
  • Human Ortholog
    RPTOR, regulatory associated protein of MTOR complex 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPTOR, regulatory associated protein of MTOR complex 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KOG1, Mip1
  • Links
    NCBI Gene ID: 57521
    neXtProt AC: NX_Q8N122
    UniProt: Q8N122

  • Chr Location
    17q25.3; chr17:80544825-80966373 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 80210
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RPTOR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 6 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025583 Ensembl Gene Model | MGI Sequence Detail 296672 C57BL/6J ±  kb
    transcript ENSMUST00000026671 Ensembl | MGI Sequence Detail 6594 Not Applicable  
    polypeptide ENSMUSP00000026671 Ensembl | MGI Sequence Detail 1335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 5
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 113
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:266104 Choi JH, et al., mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory