Rptor
Gene Detail

Symbol Name ID

Rptor regulatory associated protein of MTOR, complex 1 MGI:1921620

Synonyms

4932417H02Rik, mKIAA1303, Rap, raptor

Feature Type

protein coding gene

Genetic Map

Chromosome 11

83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:119602905-119899576 bp, + strand From VEGA annotation of GRCm38   296672 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:80210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rptor

Human homologs

Human Homolog		RPTOR, regulatory associated protein of MTOR, complex 1
NCBI Gene ID		57521
neXtProt AC		NX_Q8N122
Human Synonyms		KOG1, Mip1
Human Chr (Location)		17q25.3; chr17:78518625-78940173 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(73) : Targeted(8) Gene trapped(65)
 

Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell growth, cellular response to amino acid stimulus, ...
Component	cytoplasm, dendrite, ...
Function	14-3-3 protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (34)    Tissues (31)    Images (10)
Theiler Stages: 1, 19, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	29
Western blot	4

cDNA source data(109)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(113) cDNA(112) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000004025 (Evidence)
Ensembl Gene Model	ENSMUSG00000025583 (Evidence)
Entrez Gene	74370 (Evidence)
UniGene	209933
DFCI	TC1582202, TC1585344, TC1589665, TC1597378, TC1601414, TC1668120
DoTS	DT.101153653, DT.101351325, DT.101384243, DT.489113, DT.91421311, DT.94285172
NIA Mouse Gene Index	U043252
Consensus CDS Project	CCDS25720.1
International Mouse Knockout Project Status	Rptor

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004025	VEGA Gene Model | MGI Sequence Detail	296672	C57BL/6J
transcript	OTTMUST00000008948	VEGA | MGI Sequence Detail	6594	Not Applicable
polypeptide	OTTMUSP00000004362	VEGA | MGI Sequence Detail	1335	Not Applicable

All sequences(82) RefSeq(2) UniProt(11)

Polymorphisms

SNPs(693 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR000357	HEAT
InterPro	IPR004083	Regulatory associated protein of TOR
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000013735	regulatory-associated protein of mTOR

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194626 Kellersch B, et al., Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood. 2013 Jan 10;121(2):298-307
All references(76)