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Rptor
Gene Detail
 Symbol
Name
ID
Rptor
regulatory associated protein of MTOR, complex 1
MGI:1921620
Synonyms 4932417H02Rik, mKIAA1303, Rap, raptor
Feature Type protein coding gene
Genetic Map
Chromosome 11
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:119602905-119899576 bp, + strand
From VEGA annotation of GRCm38

  296672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rptor

Human
homologs
Human Homolog RPTOR, regulatory associated protein of MTOR, complex 1
NCBI Gene ID 57521
neXtProt AC  NX_Q8N122
Human Synonyms  KOG1, Mip1
Human Chr (Location)  17q25.3; chr17:80544825-80966373 (+)  GRCh38
Alleles
and
phenotypes
All alleles(74) : Targeted(9) Gene trapped(65)
 
Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell growth, cellular response to amino acid stimulus, ...
Component cytoplasm, dendrite, ...
Function 14-3-3 protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (34)    Tissues (31)    Images (10)
Theiler Stages: 1, 19, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 29
Western blot 4
cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(114) cDNA(113) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000004025 (Evidence)
Ensembl Gene ModelENSMUSG00000025583 (Evidence)
Entrez Gene74370 (Evidence)
UniGene209933
DFCITC1582202, TC1585344, TC1589665, TC1597378, TC1601414, TC1668120
DoTSDT.101153653, DT.101351325, DT.101384243, DT.489113, DT.91421311, DT.94285172
NIA Mouse Gene IndexU043252
Consensus CDS ProjectCCDS25720.1
International Mouse Knockout Project StatusRptor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004025 VEGA Gene Model | MGI Sequence Detail 296672 C57BL/6J ±  kb
transcript OTTMUST00000008948 VEGA | MGI Sequence Detail 6594 Not Applicable 
polypeptide OTTMUSP00000004362 VEGA | MGI Sequence Detail 1335 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(10) UniProt(11)
Polymorphisms SNPs within 2kb(759 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000357 HEAT
InterPro IPR004083 Regulatory associated protein of TOR
InterPro IPR027466 Regulatory-associated protein of TOR, metazoan
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013735 regulatory-associated protein of mTOR
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206820 Shin J, et al., Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):E776-83
All references(83)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory