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Rptor Gene Detail
Summary
  • Symbol
    Rptor
  • Name
    regulatory associated protein of MTOR, complex 1
  • Synonyms
    4932417H02Rik, mKIAA1303, Rap, raptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921620
    NCBI Gene: 74370
  • Gene Overview
    MyGene.info: RPTOR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:119602905-119899576 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      296672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RPTOR, regulatory associated protein of MTOR complex 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPTOR, regulatory associated protein of MTOR complex 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KOG1, Mip1
  • Links
    NCBI Gene ID: 57521
    neXtProt AC: NX_Q8N122
    UniProt: Q8N122

  • Chr Location
    17q25.3; chr17:80544825-80966373 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 80210
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RPTOR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 6 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004025 VEGA Gene Model | MGI Sequence Detail 296672 C57BL/6J ±  kb
    transcript OTTMUST00000008948 VEGA | MGI Sequence Detail 6594 Not Applicable  
    polypeptide OTTMUSP00000004362 VEGA | MGI Sequence Detail 1335 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      749 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 5
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 111
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264740 Zhu PJ, et al., mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors. Nat Neurosci. 2018 Jun;21(6):799-802

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory