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Rptor
Gene Detail
Symbol

Name
ID
Rptor
regulatory associated protein of MTOR, complex 1
MGI:1921620
Synonyms
4932417H02Rik, mKIAA1303, Rap, raptor
Feature Type
protein coding gene
Genetic Map
Chromosome 11
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:119602905-119899576 bp, + strand
From VEGA annotation of GRCm38

  296672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RPTOR
Gene Tree: Rptor

Human
homologs
RPTOR, regulatory associated protein of MTOR, complex 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57521
neXtProt AC: NX_Q8N122

Human Synonyms: KOG1, Mip1

Human Chr (Location): 17q25.3; chr17:80544825-80966373 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(65) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in lethality prior to somitogenesis. Mice homozygous for a conditional allele activated in dendritic cells exhibit increased susceptibility to induced colitis and expansion of certain populations of dendritic cells.
 
Interactions
Rptor interacts with 410 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell growth, cellular response to amino acid stimulus, ...
Component cytoplasm, dendrite, ...
Function 14-3-3 protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (34)    Tissues (31)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 29
Western blot 4
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rptor    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000004025 (Evidence)
Ensembl Gene Model ENSMUSG00000025583 (Evidence)
Entrez Gene 74370 (Evidence)
DFCI TC1597378, TC1582202, TC1589665, TC1585344, TC1601414, TC1668120
DoTS DT.489113, DT.101384243, DT.101153653, DT.101351325, DT.91421311, DT.94285172
NIA Mouse Gene Index U043252
Consensus CDS Project CCDS25720.1
International Mouse Phenotyping Consortium Status Rptor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004025 VEGA Gene Model | MGI Sequence Detail 296672 C57BL/6J ±  kb
transcript OTTMUST00000008948 VEGA | MGI Sequence Detail 6594 Not Applicable 
polypeptide OTTMUSP00000004362 VEGA | MGI Sequence Detail 1335 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(14) UniProt(11)
Polymorphisms
SNPs within 2kb(759 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000357 HEAT
InterPro IPR004083 Regulatory associated protein of TOR
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013735 regulatory-associated protein of mTOR
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219960 Ye P, et al., An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol Cell. 2015 Feb 19;57(4):708-20
All references(99)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory